DOM: Difference between revisions

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'''2,5-Dimethoxy-4-methylamphetamine''' ('''DOM''') or '''STP''' is a [[psychedelics|psychedelic drug]] of the [[Phenethylamines|substituted phenethylamine]] and [[Amphetamines|substituted amphetamine]] chemical classes. It is a member of the [[DOx]] family of compounds.

~~This substance~~ was first ~~used recreationally~~ in the ~~mid~~-~~1960s and~~ has very limited history of human usage prior to the 1991 publication of its synthesis and pharmacology in the ''[[PiHKAL]]'' (''Phenethylamines i Have Known And Loved'').<ref name="PiHKAL">http://www.erowid.org/library/books_online/pihkal/pihkal.shtml</ref> by [[Alexander Shulgin]]. In modern times it is used as a recreational drug and an entheogen, rarely sold on the streets and almost exclusively obtained as a grey area research chemical through the use of online vendors.

DOM was first synthesized and tested in 1963 by Alexander Shulgin, who was investigating the effect of 4-position substitutions on psychedelic amphetamines.<ref>Shulgin, Alexander (1991). Pihkal : a chemical love story. Berkeley, CA: Transform Press. pp. 53–56.</ref> It has very limited history of human usage prior to the 1991 publication of its synthesis and pharmacology in the ''[[PiHKAL]]'' (''Phenethylamines i Have Known And Loved'').<ref name="PiHKAL">http://www.erowid.org/library/books_online/pihkal/pihkal.shtml</ref> by [[Alexander Shulgin]]. In modern times it is used as a recreational drug and an entheogen, rarely sold on the streets and almost exclusively obtained as a grey area research chemical through the use of online vendors.

DOM is a highly dose sensitive psychedelic that is often sold on blotting paper and known for its strong visuals and intense body load. Many reports also indicate that the effects of this chemical may be overly intense for those who are not already experienced with psychedelics.

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==Pharmacology==

DOM ~~acts as~~ a selective 5-HT2A, 5-HT2B, and 5-HT2C receptor partial agonist. Its psychedelic effects are mediated ~~via~~ its ~~actions on~~ the 5-~~HT2A~~ receptor. Due to its selectivity, DOM is often used in scientific research when studying the 5-HT2 receptor subfamily.

DOM is a selective [[5-HT2A receptor|5-HT2A]], [[5-HT2B receptor|5-HT2B]], and [[5-HT2C receptor|5-HT2C receptor]] [[partial agonist]]. Its psychedelic effects are mediated by its [[agonist]]ic properties at the 5-HT2A receptor. Due to its selectivity, DOM is often used in scientific research when studying the [[5-HT2|5-HT2 receptor]] subfamily. DOM is a [[Chirality (chemistry)|chiral]] molecule, and ''R''-(-)-DOM is the more active [[enantiomer]], functioning as a potent agonist of the serotonin [[5-HT]] family of receptors; mainly of the [[5-HT2]] subtype.<ref>Sanders-Bush, Burris, KD; Knoth, K, (September 1988). "Lysergic acid diethylamide and 2,5-dimethoxy-4-methylamphetamine are partial agonists at serotonin receptors linked to phosphoinositide hydrolysis" Journal of Pharmacology and Experimental Therapeutics '''246''' 3 924–928</ref>

=Subjective effects=

@@ Line 33: / Line 33: @@
 '''2,5-Dimethoxy-4-methylamphetamine''' ('''DOM''') or '''STP''' is a [[psychedelics|psychedelic drug]] of the [[Phenethylamines|substituted phenethylamine]] and [[Amphetamines|substituted amphetamine]] chemical classes. It is a member of the [[DOx]] family of compounds.
-This substance was first used recreationally in the mid-1960s and has very limited history of human usage prior to the 1991 publication of its synthesis and pharmacology in the ''[[PiHKAL]]'' (''Phenethylamines i Have Known And Loved'').<ref name="PiHKAL">http://www.erowid.org/library/books_online/pihkal/pihkal.shtml</ref> by [[Alexander Shulgin]]. In modern times it is used as a recreational drug and an entheogen, rarely sold on the streets and almost exclusively obtained as a grey area research chemical through the use of online vendors.
+DOM was first synthesized and tested in 1963 by Alexander Shulgin, who was investigating the effect of 4-position substitutions on psychedelic amphetamines.<ref>Shulgin, Alexander (1991). Pihkal : a chemical love story. Berkeley, CA: Transform Press. pp. 53–56.</ref> It has very limited history of human usage prior to the 1991 publication of its synthesis and pharmacology in the ''[[PiHKAL]]'' (''Phenethylamines i Have Known And Loved'').<ref name="PiHKAL">http://www.erowid.org/library/books_online/pihkal/pihkal.shtml</ref> by [[Alexander Shulgin]]. In modern times it is used as a recreational drug and an entheogen, rarely sold on the streets and almost exclusively obtained as a grey area research chemical through the use of online vendors.
 DOM is a highly dose sensitive psychedelic that is often sold on blotting paper and known for its strong visuals and intense body load. Many reports also indicate that the effects of this chemical may be overly intense for those who are not already experienced with psychedelics.
@@ Line 42: / Line 42: @@
 ==Pharmacology==
-DOM acts as a selective 5-HT2A, 5-HT2B, and 5-HT2C receptor partial agonist. Its psychedelic effects are mediated via its actions on the 5-HT2A receptor. Due to its selectivity, DOM is often used in scientific research when studying the 5-HT2 receptor subfamily.
+DOM is a selective [[5-HT2A receptor|5-HT<sub>2A</sub>]], [[5-HT2B receptor|5-HT<sub>2B</sub>]], and [[5-HT2C receptor|5-HT<sub>2C</sub> receptor]] [[partial agonist]]. Its psychedelic effects are mediated by its [[agonist]]ic properties at the 5-HT<sub>2A</sub> receptor. Due to its selectivity, DOM is often used in scientific research when studying the [[5-HT2|5-HT<sub>2</sub> receptor]] subfamily.  DOM is a [[Chirality (chemistry)|chiral]] molecule, and ''R''-(-)-DOM is the more active [[enantiomer]], functioning as a potent agonist of the serotonin [[5-HT]] family of receptors; mainly of the [[5-HT2]] subtype.<ref>Sanders-Bush, Burris, KD; Knoth, K, (September 1988). "Lysergic acid diethylamide and 2,5-dimethoxy-4-methylamphetamine are partial agonists at serotonin receptors linked to phosphoinositide hydrolysis" Journal of Pharmacology and Experimental Therapeutics '''246''' 3 924–928</ref>
 =Subjective effects=