4-AcO-DMT: Difference between revisions

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'''Psilacetin''' (also known as '''O-Acetylpsilocin''', '''4-Acetoxy-DMT''', or '''4-AcO-DMT''') is a synthetically produced psychoactive drug and has been suggested by David Nichols to be a potentially useful alternative to [[Psilocin#Psilocybin|psilocybin]] for pharmacological studies, as they are both believed to be prodrugs of [[psilocin]].<ref>Improvements to the Synthesis of Psilocybin and a Facile Method for

Preparing the O-Acetyl Prodrug of Psilocin | http://www.erowid.org/archive/rhodium/pdf/nichols/nichols-psilocin.pdf</ref> ~~However, many~~ report that psilacetin~~'s effects differ greatly from~~ that ~~of psilocybin~~ and psilocin ~~suggesting~~ that ~~it may~~ be active ~~intself before metabolism~~.

Preparing the O-Acetyl Prodrug of Psilocin | http://www.erowid.org/archive/rhodium/pdf/nichols/nichols-psilocin.pdf</ref>

In the body psilacetin is deacetylated to psilocin by deacetylases during first pass metabolism and during subsequent passes through the liver (evident as psilacetin is also active via parenteral routes of ingestion).

There are however claims of subjective differences in effect between the acetylated and not acetylated forms of psilocin.<ref>http://www.erowid.org/experiences/subs/exp_4AcODMT.shtml</ref> Some users report that psilacetin lasts slightly longer than psilocin; others report that it lasts for a considerably shorter time. Many users report less body load and nausea compared to psilocin. Some users find that the visual distortions produced by psilacetin more closely resemble those produced by [[DMT]] than those produced by psilocin. These differences could be possible if psilacetin is active itself and not merely as a prodrug. Most users, however, can not tell the difference between these two compounds when ingested.

=Chemistry=

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 '''Psilacetin''' (also known as '''O-Acetylpsilocin''', '''4-Acetoxy-DMT''', or '''4-AcO-DMT''') is a synthetically produced psychoactive drug and has been suggested by David Nichols to be a potentially useful alternative to [[Psilocin#Psilocybin|psilocybin]] for pharmacological studies, as they are both believed to be prodrugs of [[psilocin]].<ref>Improvements to the Synthesis of Psilocybin and a Facile Method for
-Preparing the O-Acetyl Prodrug of Psilocin | http://www.erowid.org/archive/rhodium/pdf/nichols/nichols-psilocin.pdf</ref> However, many report that psilacetin's effects differ greatly from that of psilocybin and psilocin suggesting that it may be active intself before metabolism.
+Preparing the O-Acetyl Prodrug of Psilocin | http://www.erowid.org/archive/rhodium/pdf/nichols/nichols-psilocin.pdf</ref>
+In the body psilacetin is deacetylated to psilocin by deacetylases during first pass metabolism and during subsequent passes through the liver (evident as psilacetin is also active via parenteral routes of ingestion).
+There are however claims of subjective differences in effect between the acetylated and not acetylated forms of psilocin.<ref>http://www.erowid.org/experiences/subs/exp_4AcODMT.shtml</ref> Some users report that psilacetin lasts slightly longer than psilocin; others report that it lasts for a considerably shorter time. Many users report less body load and nausea compared to psilocin. Some users find that the visual distortions produced by psilacetin more closely resemble those produced by [[DMT]] than those produced by psilocin. These differences could be possible if psilacetin is active itself and not merely as a prodrug. Most users, however, can not tell the difference between these two compounds when ingested.
 =Chemistry=