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SAM-e: Difference between revisions
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==Toxicity and harm potential== | ==Toxicity and harm potential== | ||
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There are no clinically significant side-effects of Sam-e supplementation acutely. Although side-effects are not commonly reported with SAMe, numerous studies note a small set of participants who experience [[mania]] after supplementing SAMe. It is not common, but it does appear to be related to SAMe supplementation for unknown reasons; it has been reported in some persons without history of mania as well and does not appear to be related to any pathological condition per se.<ref> S-adenosylmethionine (SAM-e) for the treatment of depression in people living with HIV/AIDS | http://www.ncbi.nlm.nih.gov/pmc/articles/PMC535560/</ref><ref> Role of S-adenosyl-L-methionine in the treatment of depression: a review of the evidence. | http://www.ncbi.nlm.nih.gov/pubmed/12420702</ref> | There are no clinically significant side-effects of Sam-e supplementation acutely. Although side-effects are not commonly reported with SAMe, numerous studies note a small set of participants who experience [[mania]] after supplementing SAMe. It is not common, but it does appear to be related to SAMe supplementation for unknown reasons; it has been reported in some persons without history of mania as well and does not appear to be related to any pathological condition per se.<ref> S-adenosylmethionine (SAM-e) for the treatment of depression in people living with HIV/AIDS | http://www.ncbi.nlm.nih.gov/pmc/articles/PMC535560/</ref><ref> Role of S-adenosyl-L-methionine in the treatment of depression: a review of the evidence. | http://www.ncbi.nlm.nih.gov/pubmed/12420702</ref> | ||