4-AcO-DMT: Difference between revisions

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{| class="wikitable" align="right"

! colspan="2" style="background:lightblue;width:200px;font-size:10pt" | ~~Psilocetin~~ (4-AcO-DMT)

! colspan="2" style="background:lightblue;width:200px;font-size:10pt" | Psilacetin (4-AcO-DMT)

|-

| colspan="2" style="text-align:center;font-size:7pt" | [[Image:~~Psilocetin~~.png|noframe|243px]] The skeletal formula of ~~Psilocetin~~ (4-AcO-DMT).

| colspan="2" style="text-align:center;font-size:7pt" | [[Image:Psilacetin.png|noframe|243px]] The skeletal formula of Psilacetin (4-AcO-DMT).

|-

| colspan="2" style="background:lightblue;text-align:center;font-size:9pt" | '''Dosage'''

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|}

'''Psilacetin''' (also known as '''O-Acetylpsilocin''', '''4-Acetoxy-DMT''', or '''4-AcO-DMT''') is a synthetically produced psychoactive drug and has been suggested by David Nichols to be a potentially useful alternative to [[Psilocin#Chemistry|psilocybin]] for pharmacological studies, as they are both believed to be prodrugs of [[psilocin]]. However, many report that ~~psilocetin~~'s effects differ greatly from that of psilocybin and psilocin.

'''Psilacetin''' (also known as '''O-Acetylpsilocin''', '''4-Acetoxy-DMT''', or '''4-AcO-DMT''') is a synthetically produced psychoactive drug and has been suggested by David Nichols to be a potentially useful alternative to [[Psilocin#Chemistry|psilocybin]] for pharmacological studies, as they are both believed to be prodrugs of [[psilocin]]. However, many report that Psilacetin's effects differ greatly from that of psilocybin and psilocin.

=Chemistry=

[[File:Tryptamine_rests.png|thumb|255px|right|General formula of a tryptamine molecule.]]

[[File:~~Psilocetin~~.png|thumb|255px|right|Skeletal formula of ~~psilocetin~~ molecule.]]

[[File:Psilacetin.png|thumb|255px|right|Skeletal formula of Psilacetin molecule.]]

~~Psilocetin~~ is made up of a tryptamine backbone with an acetoxy group attached to carbon R4 of the indole ring, and two methyl groups substituted onto the nitrogen RN1 and RN2.

Psilacetin is made up of a tryptamine backbone with an acetoxy group attached to carbon R4 of the indole ring, and two methyl groups substituted onto the nitrogen RN1 and RN2.

=Pharmacology=

~~Psilocetin~~ acts as a 5-HT2A, 5-HT2C and 5-HT1A [[Agonist#Agonists|partial agonist]]; the psychedelic effects are believed to come from ~~psilocetin~~'s efficacy at the 5-HT2A receptors. At high doses, there is some efficacy to noradrenaline receptors.

Psilacetin acts as a 5-HT2A, 5-HT2C and 5-HT1A [[Agonist#Agonists|partial agonist]]; the psychedelic effects are believed to come from Psilacetin's efficacy at the 5-HT2A receptors. At high doses, there is some efficacy to noradrenaline receptors.

=Subjective effects=

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=Toxicity and Harm Potential=

==Lethal Dosage==

The LD50 of ~~psilocetin~~ has been extrapolated from animal results to 800mg for an average human.

The LD50 of Psilacetin has been extrapolated from animal results to 800mg for an average human.

==Tolerance and Addiction Potential==

~~Psilocetin~~ tolerance lasts for approximately a week, meaning that it is very difficult to form an addiction to this substance. It also has a high cross-tolerance, affecting the potency of other tryptamines.

Psilacetin tolerance lasts for approximately a week, meaning that it is very difficult to form an addiction to this substance. It also has a high cross-tolerance, affecting the potency of other tryptamines.

=Legal Issues=

Possession and sale of ~~psilocetin~~ is unscheduled in most countries.

Possession and sale of Psilacetin is unscheduled in most countries.

*'''UK:''' Could be considered illegal under the 1971 Misuse of Drugs Act as it metabolises into [[psilocin]].

*'''USA:''' Could be considered illegal under the Federal Analog Act as an analogue of psilocin.

=See Also=

*[[Portal:Trip Reports#4-AcO-DMT|~~Psilocetin~~ Trip Reports]]

*[[Portal:Trip Reports#4-AcO-DMT|Psilacetin Trip Reports]]

*[[Psychedelics]]

*[[Tryptamines]]

*[[Psilocin]]

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 {| class="wikitable" align="right"
-! colspan="2" style="background:lightblue;width:200px;font-size:10pt" | Psilocetin (4-AcO-DMT)
+! colspan="2" style="background:lightblue;width:200px;font-size:10pt" | Psilacetin (4-AcO-DMT)
 |-
-| colspan="2" style="text-align:center;font-size:7pt" | [[Image:Psilocetin.png|noframe|243px]]<br />The skeletal formula of Psilocetin (4-AcO-DMT).
+| colspan="2" style="text-align:center;font-size:7pt" | [[Image:Psilacetin.png|noframe|243px]]<br />The skeletal formula of Psilacetin (4-AcO-DMT).
 |-
 | colspan="2" style="background:lightblue;text-align:center;font-size:9pt" | '''Dosage'''
@@ Line 32: / Line 32: @@
 |}
-'''Psilacetin''' (also known as '''O-Acetylpsilocin''', '''4-Acetoxy-DMT''', or '''4-AcO-DMT''') is a synthetically produced psychoactive drug and has been suggested by David Nichols to be a potentially useful alternative to [[Psilocin#Chemistry|psilocybin]] for pharmacological studies, as they are both believed to be prodrugs of [[psilocin]]. However, many report that psilocetin's effects differ greatly from that of psilocybin and psilocin.
+'''Psilacetin''' (also known as '''O-Acetylpsilocin''', '''4-Acetoxy-DMT''', or '''4-AcO-DMT''') is a synthetically produced psychoactive drug and has been suggested by David Nichols to be a potentially useful alternative to [[Psilocin#Chemistry|psilocybin]] for pharmacological studies, as they are both believed to be prodrugs of [[psilocin]]. However, many report that Psilacetin's effects differ greatly from that of psilocybin and psilocin.
 =Chemistry=
 [[File:Tryptamine_rests.png|thumb|255px|right|General formula of a tryptamine molecule.]]
-[[File:Psilocetin.png|thumb|255px|right|Skeletal formula of psilocetin molecule.]]
+[[File:Psilacetin.png|thumb|255px|right|Skeletal formula of Psilacetin molecule.]]
-Psilocetin is made up of a tryptamine backbone with an acetoxy group attached to carbon R<sub>4</sub> of the indole ring, and two methyl groups substituted onto the nitrogen R<sub>N1</sub> and R<sub>N2</sub>.
+Psilacetin is made up of a tryptamine backbone with an acetoxy group attached to carbon R<sub>4</sub> of the indole ring, and two methyl groups substituted onto the nitrogen R<sub>N1</sub> and R<sub>N2</sub>.
 =Pharmacology=
-Psilocetin acts as a 5-HT<sub>2A</sub>, 5-HT<sub>2C</sub> and 5-HT<sub>1A</sub> [[Agonist#Agonists|partial agonist]]; the psychedelic effects are believed to come from psilocetin's efficacy at the 5-HT<sub>2A</sub> receptors. At high doses, there is some efficacy to noradrenaline receptors.
+Psilacetin acts as a 5-HT<sub>2A</sub>, 5-HT<sub>2C</sub> and 5-HT<sub>1A</sub> [[Agonist#Agonists|partial agonist]]; the psychedelic effects are believed to come from Psilacetin's efficacy at the 5-HT<sub>2A</sub> receptors. At high doses, there is some efficacy to noradrenaline receptors.
 =Subjective effects=
@@ Line 103: / Line 103: @@
 =Toxicity and Harm Potential=
 ==Lethal Dosage==
-The LD<sub>50</sub> of psilocetin has been extrapolated from animal results to 800mg for an average human.
+The LD<sub>50</sub> of Psilacetin has been extrapolated from animal results to 800mg for an average human.
 ==Tolerance and Addiction Potential==
-Psilocetin tolerance lasts for approximately a week, meaning that it is very difficult to form an addiction to this substance. It also has a high cross-tolerance, affecting the potency of other tryptamines.
+Psilacetin tolerance lasts for approximately a week, meaning that it is very difficult to form an addiction to this substance. It also has a high cross-tolerance, affecting the potency of other tryptamines.
 =Legal Issues=
-Possession and sale of psilocetin is unscheduled in most countries.
+Possession and sale of Psilacetin is unscheduled in most countries.
 *'''UK:''' Could be considered illegal under the 1971 Misuse of Drugs Act as it metabolises into [[psilocin]].
 *'''USA:''' Could be considered illegal under the Federal Analog Act as an analogue of psilocin.
 =See Also=
-*[[Portal:Trip Reports#4-AcO-DMT|Psilocetin Trip Reports]]
+*[[Portal:Trip Reports#4-AcO-DMT|Psilacetin Trip Reports]]
 *[[Psychedelics]]
 *[[Tryptamines]]
 *[[Psilocin]]