3-MeO-PCE: Difference between revisions

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*5:11 both snorted another 10mg

*5:30 actually pretty dissed out now bro

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| ''[[3-MeO-PCE/Summary|Summary sheet: 3-MeO-PCE]]''

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'''3-MeO-PCE''' ('''3-Methoxyeticyclidine''') is a chemical of the [[Chemical class::arylcyclohexylamine]] class which acts as a [[hallucinogenic]] [[Psychoactive class::dissociative]].

It has recently become available on the online grey area research chemical market and has a similar effect profile to that of [[3-Meo-PCP]].

==Chemistry==

==Pharmacology==

3-MeO-PCE acts as an [[NMDA receptor antagonist]]. NMDA receptors allow for electrical signals to pass between neurons in the brain and spinal column; for the signals to pass, the receptor must be open. Dissociatives close the NMDA receptors by blocking them. This disconnection of neurons leads to loss of feeling, difficulty moving, and eventually an almost identical equivalent of the famous “[http://en.wikipedia.org/wiki/K-hole k-hole].”

3-MeO-PCE has Ki values of 61 nM for the NMDA receptor, 115 nM for the serotonin transporter, 4519 nM for the σ1 receptor and 525 nM for the σ2 receptor.[6]

==Subjective effects==

3-MeO-PCE can be said to share extremely similar properties to that of [[3-MeO-PCP]] but with a considerably higher risk of inducing dangerous [[psychosis]] which may make it dangerous to use regardless of the setting.

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*'''[[Effect::Auditory distortion|Distortions]]'''

*'''[[Effect::Auditory hallucinations|Hallucinations]]'''

==Toxicity and harm potential==

The toxicity and long-term health effects of recreational 3-MeO-PCP use do not seem to have been studied in any scientific context and the exact [[Toxicity::toxic dosage is unknown]]. This is because 3-MeO-PCP has very little history of human usage.

===Psychosis===

3-MeO-PCE has been reported to cause [[psychosis]] and mania at a significantly higher rate than other [[dissociative]]s such as [[ketamine]], [[diphenidine]], or [[MXE]]. There are a large number of experience reports online which describe states of "psychotic delirium, amnesia, mania, and other serious consequences" after abusing the drug.

It is strongly recommended that one use extreme caution and [[responsible drug use|harm reduction]] practices when using this drug.

*Users should avoid taking the drug multiple days in a row or becoming addicted to it as this increases the risk of severe adverse effects.

*The recommended dosage range should not be exceeded as high doses can trigger these effects as well.

*Users should start with extremely low doses and work their way up as slowly as possible. [[Volumetric liquid dosing|Volumetric liquid dosing]] should preferably be used due to the drug's potency; most standard milligram scales cannot accurately weigh out doses below 10-15mg.<ref>3-MeO-PCP (Tripsit) | https://wiki.tripsit.me/wiki/3-MeO-PCE</ref>

*[[Compulsive redosing]] before one has fully sobered up is not recommended and can result in too high of a dose.

Due to the risk of psychosis, it is not recommended to combine this drug with other substances, especially [[stimulant]]s, [[psychedelic]]s, or other [[dissociative]]s like [[MXE]]. [https://www.google.com/ Independent research] should always be done to ensure that a combination of two or more substances is safe before consumption.

It is strongly recommended that one use [[responsible drug use|harm reduction practices]] when using this drug.

===Tolerance and addiction potential===

The chronic use of 3-MeO-PCE can be considered [[Addiction potential::highly addictive with a high potential for adverse side effects such as psychosis]]. In comparison to other [[dissociative]]s, 3-MeO-PCE has been reported to be more addictive than [[MXE]], [[diphenidine]], [[ephenidine]], and [[ketamine]]. When addiction has developed, cravings and [[withdrawal effects]] may occur if a person suddenly stops their usage. There have been multiple reports across the internet of people becoming seriously addicted daily users of this substance so serious precautions and considerations should be taken before trying this substance.

Tolerance to many of the effects of 3-MeO-PCE develops [[Time to full tolerance::with prolonged and repeated use]]. This results in users having to administer increasingly large doses to achieve the same effects. After that, it takes about [[Time to half tolerance::3 - 7 days]] for the tolerance to be reduced to half and [[Time to zero tolerance::1 - 2 weeks]] to be back at baseline (in the absence of further consumption). 3-MeO-PCE presents cross-tolerance with [[Cross-tolerance::all [[dissociative]]s]], meaning that after the consumption of 3-MeO-PCE, all [[dissociative]]s will have a reduced effect.

===Urinary tract effects===

In terms of its long-term health effects when used repeatedly and with excess for extended periods of time, 3-MeO-PCE seems to exhibit almost identical bladder and urinary tract problems to those found within [[ketamine]], but to a lesser extent. This is because 3-MeO-PCE is far more potent than ketamine so significantly less of drug needs to be consumed. Symptoms of ketamine-induced cystitis can become extremely serious and can be described as:

*'''Urinary frequency''' - Urinary frequency is the need to empty the bladder every few minutes.

*'''Urinary urgency''' - This can be described as a sudden, compelling need to urinate.

*'''Urinary pressure''' - This is experienced as a constant sensation of fullness in the bladder that is unrelieved by urination.

*'''Pelvic and bladder pain''' - Pain can develop suddenly and severely, particularly as the bladder fills with urine.

*'''Hematuria''' - Hematuria is visible blood in the urine.

*'''Incontinence''' - This is the leakage of urine.

All of these, however, can easily be avoided by simply not using 3-MeO-PCE on a daily or even weekly basis and manually limiting one's usage of the substance.

===Dangerous interactions===

*'''[[Psychedelics]]''' - This combination is not advised because 3-MeO-PCE has been reported to cause extreme psychological disturbances such as [[psychosis]] and mania at a significantly higher rate than other [[dissociative]]s.

*'''[[Stimulants]]''' - This combination is not advised because 3-MeO-PCE has been reported to cause extreme psychological disturbances such as [[psychosis]] and mania at a significantly higher rate than other [[dissociative]]s.

==Legal issues==

*'''United Kingdom''' - It is illegal to produce, supply, or import this drug under the Psychoactive Substance Act, which came into effect on May 26th, 2016.<ref>Psychoactive Substances Act 2016 (Legislation.gov.uk) | http://www.legislation.gov.uk/ukpga/2016/2/contents/enacted</ref>

==See also==

*[[Responsible use]]

*[[4-MeO-PCP]]

*[[PCP]]

*[[Dissociatives]]

*[[Arylcyclohexylamines]]

==External links==

*[https://en.wikipedia.org/wiki/3-MeO-PCE 3-MeO-PCE (Wikipedia)]

*[https://www.erowid.org/experiences/subs/exp_3MeOPCE.shtml 3-MeO-PCE experiences (Erowid)]

*[http://drugs.tripsit.me/3-meo-pcp 3-MeO-PCE (Tripsit)]

==References==

[[Category:Psychoactive substance]]

[[Category:Arylcyclohexylamine]]

[[Category:Piperidine]]

[[Category:Dissociative]]

[[Category:Substance]]

@@ Line 17: / Line 17: @@
 *5:11 both snorted another 10mg
 *5:30 actually pretty dissed out now bro
+{{Template:Warning/3-MeO-PCE}}{{SubstanceBox/3-MeO-PCE}}
+{|
+|-
+| ''[[3-MeO-PCE/Summary|Summary sheet: 3-MeO-PCE]]''
+|}
+'''3-MeO-PCE''' ('''3-Methoxyeticyclidine''') is a chemical of the [[Chemical class::arylcyclohexylamine]] class which acts as a [[hallucinogenic]] [[Psychoactive class::dissociative]].
+It has recently become available on the online grey area research chemical market and has a similar effect profile to that of [[3-Meo-PCP]].
+==Chemistry==
+{{chemistry}}
+==Pharmacology==
+{{Main|NMDA receptor antagonist}}
+-MeO-PCE acts as an [[NMDA receptor antagonist]]. NMDA receptors allow for electrical signals to pass between neurons in the brain and spinal column; for the signals to pass, the receptor must be open. Dissociatives close the NMDA receptors by blocking them. This disconnection of neurons leads to loss of feeling, difficulty moving, and eventually an almost identical equivalent of the famous “[http://en.wikipedia.org/wiki/K-hole k-hole].”
+-MeO-PCE has Ki values of 61 nM for the NMDA receptor, 115 nM for the serotonin transporter, 4519 nM for the σ1 receptor and 525 nM for the σ2 receptor.[6]
 ==Subjective effects==
 -MeO-PCE can be said to share extremely similar properties to that of [[3-MeO-PCP]] but with a considerably higher risk of inducing dangerous [[psychosis]] which may make it dangerous to use regardless of the setting.
@@ Line 80: / Line 95: @@
 *'''[[Effect::Auditory distortion|Distortions]]'''
 *'''[[Effect::Auditory hallucinations|Hallucinations]]'''
+==Toxicity and harm potential==
+{{Main|Research chemicals#Toxicity and harm potential}}
+The toxicity and long-term health effects of recreational 3-MeO-PCP use do not seem to have been studied in any scientific context and the exact [[Toxicity::toxic dosage is unknown]]. This is because 3-MeO-PCP has very little history of human usage.
+===Psychosis===
+-MeO-PCE has been reported to cause [[psychosis]] and mania at a significantly higher rate than other [[dissociative]]s such as [[ketamine]], [[diphenidine]], or [[MXE]]. There are a large number of experience reports online which describe states of "psychotic delirium, amnesia, mania, and other serious consequences" after abusing the drug.
+It is strongly recommended that one use extreme caution and [[responsible drug use|harm reduction]] practices when using this drug.
+*Users should avoid taking the drug multiple days in a row or becoming addicted to it as this increases the risk of severe adverse effects.
+*The recommended dosage range should not be exceeded as high doses can trigger these effects as well.
+*Users should start with extremely low doses and work their way up as slowly as possible. [[Volumetric liquid dosing|Volumetric liquid dosing]] should preferably be used due to the drug's potency; most standard milligram scales cannot accurately weigh out doses below 10-15mg.<ref>3-MeO-PCP (Tripsit) | https://wiki.tripsit.me/wiki/3-MeO-PCE</ref>
+*[[Compulsive redosing]] before one has fully sobered up is not recommended and can result in too high of a dose.
+Due to the risk of psychosis, it is not recommended to combine this drug with other substances, especially [[stimulant]]s, [[psychedelic]]s, or other [[dissociative]]s like [[MXE]]. [https://www.google.com/ Independent research] should always be done to ensure that a combination of two or more substances is safe before consumption.
+It is strongly recommended that one use [[responsible drug use|harm reduction practices]] when using this drug.
+===Tolerance and addiction potential===
+The chronic use of 3-MeO-PCE can be considered [[Addiction potential::highly addictive with a high potential for adverse side effects such as psychosis]]. In comparison to other [[dissociative]]s, 3-MeO-PCE has been reported to be more addictive than [[MXE]], [[diphenidine]], [[ephenidine]], and [[ketamine]]. When addiction has developed, cravings and [[withdrawal effects]] may occur if a person suddenly stops their usage. There have been multiple reports across the internet of people becoming seriously addicted daily users of this substance so serious precautions and considerations should be taken before trying this substance.
+Tolerance to many of the effects of 3-MeO-PCE develops [[Time to full tolerance::with prolonged and repeated use]]. This results in users having to administer increasingly large doses to achieve the same effects. After that, it takes about [[Time to half tolerance::3 - 7 days]] for the tolerance to be reduced to half and [[Time to zero tolerance::1 - 2 weeks]] to be back at baseline (in the absence of further consumption). 3-MeO-PCE presents cross-tolerance with [[Cross-tolerance::all [[dissociative]]s]], meaning that after the consumption of 3-MeO-PCE, all [[dissociative]]s will have a reduced effect.
+===Urinary tract effects===
+In terms of its long-term health effects when used repeatedly and with excess for extended periods of time, 3-MeO-PCE seems to exhibit almost identical bladder and urinary tract problems to those found within [[ketamine]], but to a lesser extent. This is because 3-MeO-PCE is far more potent than ketamine so significantly less of drug needs to be consumed. Symptoms of ketamine-induced cystitis can become extremely serious and can be described as:
+*'''Urinary frequency''' - Urinary frequency is the need to empty the bladder every few minutes.
+*'''Urinary urgency''' - This can be described as a sudden, compelling need to urinate.
+*'''Urinary pressure''' - This is experienced as a constant sensation of fullness in the bladder that is unrelieved by urination.
+*'''Pelvic and bladder pain''' - Pain can develop suddenly and severely, particularly as the bladder fills with urine.
+*'''Hematuria''' - Hematuria is visible blood in the urine.
+*'''Incontinence''' - This is the leakage of urine.
+All of these, however, can easily be avoided by simply not using 3-MeO-PCE on a daily or even weekly basis and manually limiting one's usage of the substance.
+===Dangerous interactions===
+{{DangerousInteractions/Intro}}
+*'''[[Psychedelics]]''' - This combination is not advised because 3-MeO-PCE has been reported to cause extreme psychological disturbances such as [[psychosis]] and mania at a significantly higher rate than other [[dissociative]]s.
+*'''[[Stimulants]]''' - This combination is not advised because 3-MeO-PCE has been reported to cause extreme psychological disturbances such as [[psychosis]] and mania at a significantly higher rate than other [[dissociative]]s.
+{{DangerousInteractions/Dissos}}
+==Legal issues==
+{{legalStub}}
+*'''United Kingdom''' - It is illegal to produce, supply, or import this drug under the Psychoactive Substance Act, which came into effect on May 26th, 2016.<ref>Psychoactive Substances Act 2016 (Legislation.gov.uk) | http://www.legislation.gov.uk/ukpga/2016/2/contents/enacted</ref>
+==See also==
+*[[Responsible use]]
+*[[4-MeO-PCP]]
+*[[PCP]]
+*[[Dissociatives]]
+*[[Arylcyclohexylamines]]
+==External links==
+*[https://en.wikipedia.org/wiki/3-MeO-PCE 3-MeO-PCE (Wikipedia)]
+*[https://www.erowid.org/experiences/subs/exp_3MeOPCE.shtml 3-MeO-PCE experiences (Erowid)]
+*[http://drugs.tripsit.me/3-meo-pcp 3-MeO-PCE (Tripsit)]
+==References==
+<references/>
+[[Category:Psychoactive substance]]
+[[Category:Arylcyclohexylamine]]
+[[Category:Piperidine]]
+[[Category:Dissociative]]
+[[Category:Substance]]
+{{#set:Featured=true}}