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Sleep-wake cycle: Difference between revisions
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===Fast asleep=== | ===Fast asleep=== | ||
*Food is Digested throughout the night, | *Food is Digested throughout the night, sustaining insulin levels which in combination with melatonin cause the upregulation of leptin. This inhibits orexin allowing one to sleep without being distracted by hunger<ref>https://www.ncbi.nlm.nih.gov/pubmed/15572654 | Melatonin enhances leptin expression by rat adipocytes in the presence of insulin.</ref> | ||
*The falling levels of adenosine enable the cholinergic neurons in the basal forebrain to become uninhibited to activation <ref>http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3016451/#S13title | HISTAMINE IN THE REGULATION OF WAKEFULNESS</ref><ref>http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3362278/ | Adenosine inhibits glutamatergic input to basal forebrain cholinergic neurons</ref> | *The falling levels of adenosine enable the cholinergic neurons in the basal forebrain to become uninhibited to activation <ref>http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3016451/#S13title | HISTAMINE IN THE REGULATION OF WAKEFULNESS</ref><ref>http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3362278/ | Adenosine inhibits glutamatergic input to basal forebrain cholinergic neurons</ref> | ||