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Sleep-wake cycle: Difference between revisions
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===Fast asleep=== | ===Fast asleep=== | ||
* | *Food is Digested throughout the night, raising insulin levels which in combination with melatonin cause the upregulation of leptin. This inhibits orexin allowing one to sleep without being distracted by hunger<ref>https://www.ncbi.nlm.nih.gov/pubmed/15572654 | Melatonin enhances leptin expression by rat adipocytes in the presence of insulin.</ref> | ||
*The falling levels of adenosine enable the cholinergic neurons in the basal forebrain to become uninhibited to activation | *The falling levels of adenosine enable the cholinergic neurons in the basal forebrain to become uninhibited to activation <ref>http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3016451/#S13title | HISTAMINE IN THE REGULATION OF WAKEFULNESS</ref><ref>http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3362278/ | Adenosine inhibits glutamatergic input to basal forebrain cholinergic neurons</ref> | ||
* | *As adenosine is metabolized and it's levels decrease it no longer leads to the inhibition of histamine, enabling one to become vigilant and awaken.<ref>http://www.ncbi.nlm.nih.gov/pubmed/21401496 | The role of adenosine in the regulation of sleep.</ref><ref>http://www.ncbi.nlm.nih.gov/pubmed/15748171 | An adenosine A receptor agonist induces sleep by increasing GABA release in the tuberomammillary nucleus to inhibit histaminergic systems in rats.</ref> | ||
==See also== | ==See also== | ||