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Sleep-wake cycle: Difference between revisions
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===Fast asleep=== | ===Fast asleep=== | ||
*As adenosine is metabolized and it's levels decrease it no longer | *As adenosine is metabolized and it's levels decrease it no longer leads to the inhibition of histamine, enabling one to become vigilant and awaken.<ref>http://www.ncbi.nlm.nih.gov/pubmed/21401496 | The role of adenosine in the regulation of sleep.</ref><ref>http://www.ncbi.nlm.nih.gov/pubmed/15748171 | An adenosine A receptor agonist induces sleep by increasing GABA release in the tuberomammillary nucleus to inhibit histaminergic systems in rats.</ref> | ||
*The falling levels of adenosine | *The falling levels of adenosine enable the cholinergic neurons in the basal forebrain to become uninhibited to activation by histamine<ref>http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3016451/#S13title | HISTAMINE IN THE REGULATION OF WAKEFULNESS</ref> | ||
==See also== | ==See also== | ||