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5F-PB-22: Difference between revisions
>Oskykins m Text replacement - "*'''United Kingdom''' - This drug is illegal under the Psychoactive Substance Act, which came into effect on May 26th, 2016.<ref>Psychoactive Substances Act 2016 (Legislation.gov.uk) | http://www.legislation.gov.uk/ukpga/2016/2/contents/enacted</ref>" to "*'''United Kingdom''' - It is illegal to produce, supply, or import this drug under the Psychoactive Substance Act, which came into effect on May 26th, 2016.<ref>Psychoactive Substances Act 2016 (Legislation.gov.uk) | htt... |
>Oskykins m Text replacement - "5F-AKB-48" to "5F-AKB48" |
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Unlike [[cannabis]], the chronic abuse of [[synthetic cannabinoids]] has been [[Synthetic_cannabinoid#Deaths|associated with multiple deaths]] and [[Synthetic cannabinoid#Harm potential|more dangerous side effects and toxicity]] in general. Five deaths have been associated with the use of 5F-PB-22 in the United States.<ref>Perspectives of drugs: synthetic cannabinoids in Europe (European Monitoring Centre for Drugs and Drug Addiction | http://www.emcdda.europa.eu/topics/pods/synthetic-cannabinoids</ref> Therefore, it is strongly discouraged to take this substance for extended periods of time or in excessive doses. | Unlike [[cannabis]], the chronic abuse of [[synthetic cannabinoids]] has been [[Synthetic_cannabinoid#Deaths|associated with multiple deaths]] and [[Synthetic cannabinoid#Harm potential|more dangerous side effects and toxicity]] in general. Five deaths have been associated with the use of 5F-PB-22 in the United States.<ref>Perspectives of drugs: synthetic cannabinoids in Europe (European Monitoring Centre for Drugs and Drug Addiction | http://www.emcdda.europa.eu/topics/pods/synthetic-cannabinoids</ref> Therefore, it is strongly discouraged to take this substance for extended periods of time or in excessive doses. | ||
==Chemistry== | ==Chemistry== | ||
5F-PB-22, or quinolin-8-yl 1-pentyfluoro-1H-indole-3-8-carboxylate, is a synthetic [[Chemical class::indole cannabinoid]] as it contains a substituted core indole structure. This indole core is shared with other cannabinoid substances including [[PB-22]], [[JWH-018]], and [[AM2201]]. 5F-PB-22 is an ether with formula R-O-R', which can be understood as a substance with two sub-units joined through an oxygen bridge. The indole group of 5F-PB-22 is substituted at R<sub>5</sub> with a fluoropentyl chain, a substitution shared with [[5F- | 5F-PB-22, or quinolin-8-yl 1-pentyfluoro-1H-indole-3-8-carboxylate, is a synthetic [[Chemical class::indole cannabinoid]] as it contains a substituted core indole structure. This indole core is shared with other cannabinoid substances including [[PB-22]], [[JWH-018]], and [[AM2201]]. 5F-PB-22 is an ether with formula R-O-R', which can be understood as a substance with two sub-units joined through an oxygen bridge. The indole group of 5F-PB-22 is substituted at R<sub>5</sub> with a fluoropentyl chain, a substitution shared with [[5F-AKB48]]. Additionally, the indole core is substituted at R<sub>3</sub> with a carboxylic acid group. The terminal oxygen of this carboxylic acid is bonded through an ether bond to a quinoline group at location R<sub>8</sub> of the heterocycle. | ||
==Pharmacology== | ==Pharmacology== | ||
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===Physical effects=== | ===Physical effects=== | ||
*'''[[Effect::Spontaneous tactile sensations]]''' - The "body high" of 5F-PB-22 can be described as a warm and soft pleasurable, all-encompassing tingling sensation that spreads over the body. It maintains a consistent presence that quickly rises with the onset and hits its limit once the peak has been reached before immediately dissipating. | *'''[[Effect::Spontaneous tactile sensations]]''' - The "body high" of 5F-PB-22 can be described as a warm and soft pleasurable, all-encompassing tingling sensation that spreads over the body. It maintains a consistent presence that quickly rises with the onset and hits its limit once the peak has been reached before immediately dissipating. | ||
*'''[[Effect::Sedation]]''' - Generally, the effects on the user's energy levels are very sedating. This encourages one to relax, lie down, and (at higher doses) fall asleep. It produces strong sedative effects that can be described as on par with [[JWH-018]] and more sedating when compared to [[THC]], [[JWH-073]], [[THJ-018]], [[AM-2201]], or [[5F-UR-144]] but less than that of [[5F- | *'''[[Effect::Sedation]]''' - Generally, the effects on the user's energy levels are very sedating. This encourages one to relax, lie down, and (at higher doses) fall asleep. It produces strong sedative effects that can be described as on par with [[JWH-018]] and more sedating when compared to [[THC]], [[JWH-073]], [[THJ-018]], [[AM-2201]], or [[5F-UR-144]] but less than that of [[5F-AKB48]]. | ||
*'''[[Effect::Motor control loss]]''' - This substance causes a partial to moderate suppression of motor control which intensifies proportional to dose, but rarely results in a complete inability to walk and perform basic movements. | *'''[[Effect::Motor control loss]]''' - This substance causes a partial to moderate suppression of motor control which intensifies proportional to dose, but rarely results in a complete inability to walk and perform basic movements. | ||
*'''[[Effect::Appetite enhancement]]''' - As with many other cannabinoids, 5F-PB-22 causes an increase in appetite<ref>Mechoulam, R. (1984). Cannabinoids as therapeutic agents. Boca Raton, FL: CRC Press. ISBN 0-8493-5772-1.</ref>, known colloquially as "the munchies" in popular American and United Kingdom culture. Clinical studies and survey data have found that cannabis increases food enjoyment and interest in food.<ref>How Marijuana Works | http://science.howstuffworks.com/marijuana4.htm</ref> This is thought to be due to the way in which endocannabinoids in the hypothalamus activate cannabinoid receptors that are responsible for maintaining food intake.<ref>How Marijuana Works | http://science.howstuffworks.com/marijuana4.htm</ref> | *'''[[Effect::Appetite enhancement]]''' - As with many other cannabinoids, 5F-PB-22 causes an increase in appetite<ref>Mechoulam, R. (1984). Cannabinoids as therapeutic agents. Boca Raton, FL: CRC Press. ISBN 0-8493-5772-1.</ref>, known colloquially as "the munchies" in popular American and United Kingdom culture. Clinical studies and survey data have found that cannabis increases food enjoyment and interest in food.<ref>How Marijuana Works | http://science.howstuffworks.com/marijuana4.htm</ref> This is thought to be due to the way in which endocannabinoids in the hypothalamus activate cannabinoid receptors that are responsible for maintaining food intake.<ref>How Marijuana Works | http://science.howstuffworks.com/marijuana4.htm</ref> | ||
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*[[JWH-018]] | *[[JWH-018]] | ||
*[[THJ-018]] | *[[THJ-018]] | ||
*[[5F- | *[[5F-AKB48]] | ||
*[[Synthetic cannabinoid]] | *[[Synthetic cannabinoid]] | ||
*[[Cannabis]] | *[[Cannabis]] | ||