Talk:W-18: Difference between revisions

Line 1:

Recent information suggests that W-18:

A street drug feared to be stronger than any opioid known to science turns out not be an opioid at all. W-18, an experimental pain medicine first developed at the University of Alberta in Edmonton in the 1980s, doesn’t even appear to provide relief in animal pain models.

The findings appeared July 24, 2016 in a preprint report (PDF) in bioRxiv (pronounced “Bioarchive”), a non-peer-reviewed resource of Cold Spring Harbor Laboratories designed to rapidly disseminate critical research findings. The authors include scientists from the National Institute of Drug Abuse, the University of North Carolina at Chapel Hill, Memorial Sloan Kettering Cancer Center and the Scripps Research Institute.

The comprehensive study not only showed the lack of opioid effects of W-18 or a related chemical called W-15. They showed that human or mouse metabolites of the chemicals had no effect on human or mouse opioid receptors. More surprisingly, a receptorome-wide screen showed no substantial effect of the compounds or metabolites on any psychoactive drug receptor. The study marks a rare case where a potentially lethal drug of abuse is likely to be far less of a public health risk than originally believed.

<ref>http://www.forbes.com/sites/davidkroll/2016/07/28/w-18-is-not-a-super-potent-designer-opioid-as-originally-believed/#17de6fe44121</ref>

@@ Line 1: / Line 1: @@
+Recent information suggests that W-18:
+A street drug feared to be stronger than any opioid known to science turns out not be an opioid at all. W-18, an experimental pain medicine first developed at the University of Alberta in Edmonton in the 1980s, doesn’t even appear to provide relief in animal pain models.
+The findings appeared July 24, 2016 in a preprint report (PDF) in bioRxiv (pronounced “Bioarchive”), a non-peer-reviewed resource of Cold Spring Harbor Laboratories designed to rapidly disseminate critical research findings. The authors include scientists from the National Institute of Drug Abuse, the University of North Carolina at Chapel Hill, Memorial Sloan Kettering Cancer Center and the Scripps Research Institute.
+The comprehensive study not only showed the lack of opioid effects of W-18 or a related chemical called W-15. They showed that human or mouse metabolites of the chemicals had no effect on human or mouse opioid receptors. More surprisingly, a receptorome-wide screen showed no substantial effect of the compounds or metabolites on any psychoactive drug receptor. The study marks a rare case where a potentially lethal drug of abuse is likely to be far less of a public health risk than originally believed.
+<ref>http://www.forbes.com/sites/davidkroll/2016/07/28/w-18-is-not-a-super-potent-designer-opioid-as-originally-believed/#17de6fe44121</ref>
 {{Warning/W-18}}
 {{SubstanceBox/W-18}}