Methaqualone: Difference between revisions

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|}'''Methaqualone''' (brand name '''Quaalude''' in the US and '''Mandrax''' in the UK) is a central nervous system (CNS) [[psychoactive class::depressant]] of the [[chemical class::quinazolinone]] class that acts as a [[sedative]] and [[hypnotic]]. The sedative–hypnotic activity of methaqualone was first noted by researchers in the 1950s and in 1962 methaqualone itself was patented in the US by Wallace and Tiernan.<ref>US Patent 3135659 – Hydroxy and Alkoxy Aryl Quinazolones</ref> Its use peaked in the early 1970s as a hypnotic, for the treatment of insomnia, and as a [[sedative]] and [[muscle relaxant]]. It is still produced and used clandestinely as a recreational drug throughout the world. The drug was popular in the 1970s with hippies and in the disco club scene.

'''Methaqualone''' (brand name '''Quaalude''' in the US and '''Mandrax''' in the UK) is a central nervous system (CNS) [[psychoactive class::depressant]] of the [[chemical class::quinazolinone]] class that acts as a [[sedative]] and [[hypnotic]]. The sedative–hypnotic activity of methaqualone was first noted by researchers in the 1950s and in 1962 methaqualone itself was patented in the US by Wallace and Tiernan.<ref>US Patent 3135659 – Hydroxy and Alkoxy Aryl Quinazolones</ref> Its use peaked in the early 1970s as a hypnotic, for the treatment of insomnia, and as a [[sedative]] and [[muscle relaxant]]. It is still produced and used clandestinely as a recreational drug throughout the world. The drug was popular in the 1970s with hippies and in the disco club scene.

==Chemistry==

Methaqualone, or 2-methyl-3-(2-methylphenyl)-4(3H)-quinazolinone, is a compound of the quinazolinone class. Quinazolinone is a bicyclic structure containing a phenyl ring bound to another six-membered ring with two nitrogen members and a ketone group bound to R4. In methaqualone, this structure is substituted at R2 with a methyl group. Additionally, methaqualone contains a phenyl ring with a methyl group bound to R2 which is attached to the quinazolinone structure at R3.

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+|}'''Methaqualone''' (brand name '''Quaalude''' in the US and '''Mandrax''' in the UK) is a central nervous system (CNS) [[psychoactive class::depressant]] of the [[chemical class::quinazolinone]] class that acts as a [[sedative]] and [[hypnotic]]. The sedative–hypnotic activity of methaqualone was first noted by researchers in the 1950s and in 1962 methaqualone itself was patented in the US by Wallace and Tiernan.<ref>US Patent 3135659 – Hydroxy and Alkoxy Aryl Quinazolones</ref> Its use peaked in the early 1970s as a hypnotic, for the treatment of insomnia, and as a [[sedative]] and [[muscle relaxant]]. It is still produced and used clandestinely as a recreational drug throughout the world. The drug was popular in the 1970s with hippies and in the disco club scene.
-'''Methaqualone''' (brand name '''Quaalude''' in the US and '''Mandrax''' in the UK) is a central nervous system (CNS) [[psychoactive class::depressant]] of the [[chemical class::quinazolinone]] class that acts as a [[sedative]] and [[hypnotic]]. The sedative–hypnotic activity of methaqualone was first noted by researchers in the 1950s and in 1962 methaqualone itself was patented in the US by Wallace and Tiernan.<ref>US Patent 3135659 – Hydroxy and Alkoxy Aryl Quinazolones</ref> Its use peaked in the early 1970s as a hypnotic, for the treatment of insomnia, and as a [[sedative]] and [[muscle relaxant]]. It is still produced and used clandestinely as a recreational drug throughout the world. The drug was popular in the 1970s with hippies and in the disco club scene.
 ==Chemistry==
 Methaqualone, or 2-methyl-3-(2-methylphenyl)-4(3H)-quinazolinone, is a compound of the quinazolinone class. Quinazolinone is a bicyclic structure containing a phenyl ring bound to another six-membered ring with two nitrogen members and a ketone group bound to R<sub>4</sub>. In methaqualone, this structure is substituted at R<sub>2</sub> with a methyl group. Additionally, methaqualone contains a phenyl ring with a methyl group bound to R<sub>2</sub> which is attached to the quinazolinone structure at R<sub>3</sub>.