Methaqualone: Difference between revisions

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===Tolerance and addiction potential===

Methaqualone is [[Addiction potential::extremely addictive]]. Tolerance to the sedative-hypnotic effects develops [[Time to full tolerance::within a couple of days of repeated administration]]. After that, it takes about [[Time to half tolerance::3 - 7 days]] for the tolerance to be reduced to half and [[Time to zero tolerance::1 - 2 weeks]] to be back at baseline (in the absence of further consumption). Methaqualone presents cross-tolerance with [[Cross-tolerance::all [[GABA|gabaergic]] ~~and~~ [[depressants]]]], meaning that after the consumption of methaqualone all compounds of the same class will have a reduced effect.

Methaqualone is [[Addiction potential::extremely addictive]]. Tolerance to the sedative-hypnotic effects develops [[Time to full tolerance::within a couple of days of repeated administration]]. After that, it takes about [[Time to half tolerance::3 - 7 days]] for the tolerance to be reduced to half and [[Time to zero tolerance::1 - 2 weeks]] to be back at baseline (in the absence of further consumption). Methaqualone presents cross-tolerance with [[Cross-tolerance::all [[GABA|gabaergic]] [[depressants]]]], meaning that after the consumption of methaqualone all compounds of the same class will have a reduced effect.

Abrupt discontinuation of methaqualone following regular dosing over several days can result in a withdrawal phase which includes rebound symptoms such as increased anxiety and insomnia. It is possible to gradually reduce the dose over the course of several days, which will lengthen the duration of the withdrawal period but reduce the perceived intensity.

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 ===Tolerance and addiction potential===
-Methaqualone is [[Addiction potential::extremely addictive]]. Tolerance to the sedative-hypnotic effects develops [[Time to full tolerance::within a couple of days of repeated administration]]. After that, it takes about [[Time to half tolerance::3 - 7 days]] for the tolerance to be reduced to half and [[Time to zero tolerance::1 - 2 weeks]] to be back at baseline (in the absence of further consumption). Methaqualone presents cross-tolerance with [[Cross-tolerance::all [[GABA|gabaergic]] and [[depressants]]]], meaning that after the consumption of methaqualone all compounds of the same class will have a reduced effect.
+Methaqualone is [[Addiction potential::extremely addictive]]. Tolerance to the sedative-hypnotic effects develops [[Time to full tolerance::within a couple of days of repeated administration]]. After that, it takes about [[Time to half tolerance::3 - 7 days]] for the tolerance to be reduced to half and [[Time to zero tolerance::1 - 2 weeks]] to be back at baseline (in the absence of further consumption). Methaqualone presents cross-tolerance with [[Cross-tolerance::all [[GABA|gabaergic]] [[depressants]]]], meaning that after the consumption of methaqualone all compounds of the same class will have a reduced effect.
 Abrupt discontinuation of methaqualone following regular dosing over several days can result in a withdrawal phase which includes rebound symptoms such as increased anxiety and insomnia. It is possible to gradually reduce the dose over the course of several days, which will lengthen the duration of the withdrawal period but reduce the perceived intensity.