Alpha-GPC: Difference between revisions

Line 14:

'''Alpha GPC''', ('''Alpha-glycerophosphocholine'''), ('''choline alfoscerate''') is a water soluble nutrient which serves within the brain as a precursor to both [[choline]] and glycerophosphate. To humans, choline is an essential nutrient, as its role in reducing the risk of neural tube defects, fatty liver disease, and other pathologies have been documented. <ref>http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2782876/</ref> Alpha GPC is one of the three choline-containing phospholipids that can be orally supplemented (the other two being [[Citicoline]] and Phosphatidylcholine).

Alpha-GPC is ~~mostly marketed~~ due to it being the most efficient choline prodrug (able to influence both systemic and brain concentrations of choline). Due to the provision of the other half of the alpha-GPC molecule (glycerophosphate), alpha-GPC also appears to support the structure of cellular membranes, similarly to [[citicoline]].

Alpha-GPC's popularity is largely due to it being the most efficient choline prodrug (able to influence both systemic and brain concentrations of choline). Due to the provision of the other half of the alpha-GPC molecule (glycerophosphate), alpha-GPC also appears to support the structure of cellular membranes, similarly to [[citicoline]].

Athletes ~~are interested in~~ alpha-GPC due to its ability to enhance growth hormone production and to enhance power output, which has a lone pilot study in support of 600 mg alpha-GPC prior to exercise. <ref>http://jissn.biomedcentral.com/articles/10.1186/1550-2783-5-S1-P15</ref>

Athletes have been known to use alpha-GPC due to its ability to enhance growth hormone production and to enhance power output, which has a lone pilot study in support of 600 mg alpha-GPC prior to exercise. <ref>http://jissn.biomedcentral.com/articles/10.1186/1550-2783-5-S1-P15</ref>

When taken as supplement, this compound has [[psychoactive class::nootropic]] effects. It is easily available and commonly sold for this purpose through the use of online supplement vendors.

Line 26:

Choline and its metabolites are needed for three main physiological purposes: structural integrity and signaling roles for cell membranes, cholinergic neurotransmission ([[acetylcholine]] synthesis).<ref>https://dx.doi.org/10.1002%2Fmnfr.201200636</ref> This may explain why supplementing this compound results in [[nootropic]] effects.

Glycerophosphate, the other component, can also help with production of cellular membranes, but it is not ~~a very~~ well ~~investigated topic~~.

Glycerophosphate, the other component, can also help with production of cellular membranes, but this remains largely unstudied and is not well understood by the scientific literature.

==Subjective effects==

Line 38:

====Cognitive effects====

*'''[[Effect::Wakefulness]]''' - In comparison to [[~~Citicoline~~]], Alpha-GPC manifests itself primarily in a physically stimulating manner over a mental stimulation.

*'''[[Effect::Wakefulness]]''' - In comparison to [[citicoline]], Alpha-GPC manifests itself primarily in a physically stimulating manner over a mental stimulation.

*'''[[Effect::Dream potentiation]]'''

*'''[[Effect::Focus enhancement]]'''<ref>http://www.scirp.org/journal/PaperInformation.aspx?paperID=19921</ref>

Line 59:

*[[Choline]]

*[[Nootropic]]

==External links==

*[https://en.wikipedia.org/wiki/Alpha-GPC Alpha-GPC (Wikipedia)]

*[https://examine.com/supplements/alpha-gpc/ Alpha-GPC (Examine)]

==References==

@@ Line 14: / Line 14: @@
 '''Alpha GPC''', ('''Alpha-glycerophosphocholine'''), ('''choline alfoscerate''') is a water soluble nutrient which serves within the brain as a precursor to both [[choline]] and glycerophosphate. To humans, choline is an essential nutrient, as its role in reducing the risk of neural tube defects, fatty liver disease, and other pathologies have been documented. <ref>http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2782876/</ref> Alpha GPC is one of the three choline-containing phospholipids that can be orally supplemented (the other two being [[Citicoline]] and Phosphatidylcholine).
-Alpha-GPC is mostly marketed due to it being the most efficient choline prodrug (able to influence both systemic and brain concentrations of choline). Due to the provision of the other half of the alpha-GPC molecule (glycerophosphate), alpha-GPC also appears to support the structure of cellular membranes, similarly to [[citicoline]].
+Alpha-GPC's popularity is largely due to it being the most efficient choline prodrug (able to influence both systemic and brain concentrations of choline). Due to the provision of the other half of the alpha-GPC molecule (glycerophosphate), alpha-GPC also appears to support the structure of cellular membranes, similarly to [[citicoline]].
-Athletes are interested in alpha-GPC due to its ability to enhance growth hormone production and to enhance power output, which has a lone pilot study in support of 600 mg alpha-GPC prior to exercise. <ref>http://jissn.biomedcentral.com/articles/10.1186/1550-2783-5-S1-P15</ref>
+Athletes have been known to use alpha-GPC due to its ability to enhance growth hormone production and to enhance power output, which has a lone pilot study in support of 600 mg alpha-GPC prior to exercise. <ref>http://jissn.biomedcentral.com/articles/10.1186/1550-2783-5-S1-P15</ref>
 When taken as supplement, this compound has [[psychoactive class::nootropic]] effects. It is easily available and commonly sold for this purpose through the use of online supplement vendors.
@@ Line 26: / Line 26: @@
 Choline and its metabolites are needed for three main physiological purposes: structural integrity and signaling roles for cell membranes, cholinergic neurotransmission ([[acetylcholine]] synthesis).<ref>https://dx.doi.org/10.1002%2Fmnfr.201200636</ref> This may explain why supplementing this compound results in [[nootropic]] effects.
-Glycerophosphate, the other component, can also help with production of cellular membranes, but it is not a very well investigated topic.
+Glycerophosphate, the other component, can also help with production of cellular membranes, but this remains largely unstudied and is not well understood by the scientific literature.
 ==Subjective effects==
@@ Line 38: / Line 38: @@
 ====Cognitive effects====
-*'''[[Effect::Wakefulness]]''' - In comparison to [[Citicoline]], Alpha-GPC manifests itself primarily in a physically stimulating manner over a mental stimulation.
+*'''[[Effect::Wakefulness]]''' - In comparison to [[citicoline]], Alpha-GPC manifests itself primarily in a physically stimulating manner over a mental stimulation.
 *'''[[Effect::Dream potentiation]]'''
 *'''[[Effect::Focus enhancement]]'''<ref>http://www.scirp.org/journal/PaperInformation.aspx?paperID=19921</ref>
@@ Line 59: / Line 59: @@
 *[[Choline]]
 *[[Nootropic]]
+==External links==
+*[https://en.wikipedia.org/wiki/Alpha-GPC Alpha-GPC (Wikipedia)]
+*[https://examine.com/supplements/alpha-gpc/ Alpha-GPC (Examine)]
 ==References==
 <references />