Reuptake inhibitor: Difference between revisions

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==Types of reuptake inhibitors==

*A '''selective reuptake inhibitor''' will inhibit the reuptake of a specific [[neurotransmitter]] with negligible or no effects on the reuptake of other neurotransmitters. An example of this is the class of antidepressants known as selective serotonin reuptake inhibitors, or [[SSRIs]]. SSRIs ~~bind to~~ serotonin transporters (SERTs) ~~to inhibit~~ the reuptake of serotonin, increasing extracellular concentrations of the neurotransmitter.

*A '''selective reuptake inhibitor''' will inhibit the reuptake of a specific [[neurotransmitter]] with negligible or no effects on the reuptake of other neurotransmitters. An example of this is the class of antidepressants known as selective serotonin reuptake inhibitors, or [[SSRIs]]. SSRIs solely target serotonin transporters (SERTs), blocking the reuptake of serotonin, and increasing extracellular concentrations of the neurotransmitter.<ref>http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2896866/</ref>

*A '''non-selective reuptake inhibitor''' will inhibit the reuptake of more than one type of [[neurotransmitter]]. An example of this is [[cocaine]], which acts as a serotonin-noradrenaline-dopamine reuptake inhibitor, or [[SNDRI]]. Ketamine is an example of a weak SNDRI, it is non-selective because it affects the reuptake of multiple neurotransmitters.<ref>Kohrs, R; Durieux, ME (November 1998). "Ketamine: Teaching an old drug new tricks". Anesthesia & Analgesia | https://www.ncbi.nlm.nih.gov/pubmed/9806706</ref>

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 ==Types of reuptake inhibitors==
-*A '''selective reuptake inhibitor''' will inhibit the reuptake of a specific [[neurotransmitter]] with negligible or no effects on the reuptake of other neurotransmitters. An example of this is the class of antidepressants known as selective serotonin reuptake inhibitors, or [[SSRIs]]. SSRIs bind to serotonin transporters (SERTs) to inhibit the reuptake of serotonin, increasing extracellular concentrations of the neurotransmitter.
+*A '''selective reuptake inhibitor''' will inhibit the reuptake of a specific [[neurotransmitter]] with negligible or no effects on the reuptake of other neurotransmitters. An example of this is the class of antidepressants known as selective serotonin reuptake inhibitors, or [[SSRIs]]. SSRIs solely target serotonin transporters (SERTs), blocking the reuptake of serotonin, and increasing extracellular concentrations of the neurotransmitter.<ref>http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2896866/</ref>
 *A '''non-selective reuptake inhibitor''' will inhibit the reuptake of more than one type of [[neurotransmitter]]. An example of this is [[cocaine]], which acts as a serotonin-noradrenaline-dopamine reuptake inhibitor, or [[SNDRI]]. Ketamine is an example of a weak SNDRI, it is non-selective because it affects the reuptake of multiple neurotransmitters.<ref>Kohrs, R; Durieux, ME (November 1998). "Ketamine: Teaching an old drug new tricks". Anesthesia & Analgesia | https://www.ncbi.nlm.nih.gov/pubmed/9806706</ref>