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Talk:Dextrorphan: Difference between revisions
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Dextrorphan (DXO) is an active metabolite of [[dextromethorphan]]. This means that DXM is metabolized in the body by o-demethylation through the CYP2D6 enzyme to form DXO. Both are active chemicals and contribute to the [[DXM#Subjective effects|subjective effects]] experienced when active doses of DXM are consumed. | Dextrorphan (DXO) is an active metabolite of [[dextromethorphan]]. This means that DXM is metabolized in the body by o-demethylation through the CYP2D6 enzyme to form DXO. Both are active chemicals and contribute to the [[DXM#Subjective effects|subjective effects]] experienced when active doses of DXM are consumed. | ||
The pharmacology of dextrorphan is similar to that of dextromethorphan (DXM). However, dextrorphan is much more potent as an [[NMDA receptor antagonist]] as well as essentially inactive as a [[serotonin]] [[reuptake inhibitor]].<ref>Psychotropic Effects of Dextromethorphan Are Altered by the CYP2D6 Polymorphism: A Pilot Study [http://journals.lww.com/psychopharmacology/pages/articleviewer.aspx?year=1998&issue=08000&article=00014&type=abstract]</ref> One Erowid user reported excessive itchiness accompanied by a "peaceful yet emotionless state" after 340mg of the substance was consumed. <ref> | The pharmacology of dextrorphan is similar to that of dextromethorphan (DXM). However, dextrorphan is much more potent as an [[NMDA receptor antagonist]] as well as essentially inactive as a [[serotonin]] [[reuptake inhibitor]].<ref>Psychotropic Effects of Dextromethorphan Are Altered by the CYP2D6 Polymorphism: A Pilot Study [http://journals.lww.com/psychopharmacology/pages/articleviewer.aspx?year=1998&issue=08000&article=00014&type=abstract]</ref> One Erowid user reported excessive itchiness accompanied by a "peaceful yet emotionless state" after 340mg of the substance was consumed.<ref> | ||
"Erowid DXM Vault : An Unpleasant Exploration of DXO, by Student." Erowid DXM Vault : An Unpleasant Exploration of DXO, by Student. Erowid.org, 15 Sept. 2001. Web. 15 Apr. 2015 [https://www.erowid.org/chemicals/dxm/dxm_info3.shtml]</ref> | "Erowid DXM Vault : An Unpleasant Exploration of DXO, by Student." Erowid DXM Vault : An Unpleasant Exploration of DXO, by Student. Erowid.org, 15 Sept. 2001. Web. 15 Apr. 2015 [https://www.erowid.org/chemicals/dxm/dxm_info3.shtml]</ref> | ||
==See also== | ==See also== | ||