5F-PB-22: Difference between revisions

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Cannabinoids are commonly smoked or vaporized to achieve a quick [[onset]] of effects and rapid [[offset]]. 5F-PB-22 is [[oral]]ly active when dissolved in a lipid, which can increase the duration significantly. Like other [[cannabinoid]]s, it is insoluble in water but dissolves in [[ethanol]] and lipids.

Five deaths have been associated with the use of 5F-PB-22 in the United States.<ref>Perspectives of drugs: synthetic cannabinoids in Europe (European Monitoring Centre for Drugs and Drug Addiction | http://www.emcdda.europa.eu/topics/pods/synthetic-cannabinoids</ref>

Unlike [[cannabis]], the chronic abuse of [[synthetic cannabinoids]] has been [[Synthetic_cannabinoid#Deaths|associated with multiple deaths]] and [[Synthetic cannabinoid#Harm potential|more dangerous side effects and toxicity]] in general. Five deaths have been associated with the use of 5F-PB-22 in the United States.<ref>Perspectives of drugs: synthetic cannabinoids in Europe (European Monitoring Centre for Drugs and Drug Addiction | http://www.emcdda.europa.eu/topics/pods/synthetic-cannabinoids</ref> Therefore, it is strongly discouraged to take this substance for extended periods of time or in excessive doses.

==Chemistry==

5F-PB-22, or quinolin-8-yl 1-pentyfluoro-1H-indole-3-8-carboxylate, is a synthetic [[Chemical class::indole cannabinoid]] as it contains a substituted core indole structure. This indole core is shared with other cannabinoid substances including [[PB-22]], [[JWH-018]], and [[AM2201]]. 5F-PB-22 is an ether with formula R-O-R', which can be understood as a substance with two sub-units joined through an oxygen bridge. The indole group of 5F-PB-22 is substituted at R5 with a fluoropentyl chain, a substitution shared with [[5F-AKB-48]]. Additionally, the indole core is substituted at R3 with a carboxylic acid group. The terminal oxygen of this carboxylic acid is bonded through an ether bond to a quinoline group at location R8 of the heterocycle.

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 Cannabinoids are commonly smoked or vaporized to achieve a quick [[onset]] of effects and rapid [[offset]]. 5F-PB-22 is [[oral]]ly active when dissolved in a lipid, which can increase the duration significantly. Like other [[cannabinoid]]s, it is insoluble in water but dissolves in [[ethanol]] and lipids.
-Five deaths have been associated with the use of 5F-PB-22 in the United States.<ref>Perspectives of drugs: synthetic cannabinoids in Europe (European Monitoring Centre for Drugs and Drug Addiction | http://www.emcdda.europa.eu/topics/pods/synthetic-cannabinoids</ref>
+Unlike [[cannabis]], the chronic abuse of [[synthetic cannabinoids]] has been [[Synthetic_cannabinoid#Deaths|associated with multiple deaths]] and [[Synthetic cannabinoid#Harm potential|more dangerous side effects and toxicity]] in general. Five deaths have been associated with the use of 5F-PB-22 in the United States.<ref>Perspectives of drugs: synthetic cannabinoids in Europe (European Monitoring Centre for Drugs and Drug Addiction | http://www.emcdda.europa.eu/topics/pods/synthetic-cannabinoids</ref> Therefore, it is strongly discouraged to take this substance for extended periods of time or in excessive doses.
 ==Chemistry==
 F-PB-22, or quinolin-8-yl 1-pentyfluoro-1H-indole-3-8-carboxylate, is a synthetic [[Chemical class::indole cannabinoid]] as it contains a substituted core indole structure. This indole core is shared with other cannabinoid substances including [[PB-22]], [[JWH-018]], and [[AM2201]]. 5F-PB-22 is an ether with formula R-O-R', which can be understood as a substance with two sub-units joined through an oxygen bridge. The indole group of 5F-PB-22 is substituted at R<sub>5</sub> with a fluoropentyl chain, a substitution shared with [[5F-AKB-48]]. Additionally, the indole core is substituted at R<sub>3</sub> with a carboxylic acid group. The terminal oxygen of this carboxylic acid is bonded through an ether bond to a quinoline group at location R<sub>8</sub> of the heterocycle.