5-APB: Difference between revisions

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5-APB is a triple [[reuptake inhibitor]] for [[norepinephrine]], [[dopamine]] and [[serotonin]], as well as being an [[agonist]] for the [[Serotonin#The_5-HT_system|5-HT2A]] and [[Serotonin#The_5-HT_system|5-HT2B]] [[receptor]]s. It has also been speculated ~~from the structure activity relationship(SAR)~~ that 5-APB is a monoamine [[releasing agent]].

5-APB is a triple [[reuptake inhibitor]] for [[norepinephrine]], [[dopamine]] and [[serotonin]], as well as being an [[agonist]] for the [[Serotonin#The_5-HT_system|5-HT2A]] and [[Serotonin#The_5-HT_system|5-HT2B]] [[receptor]]s.<ref>The effects of benzofury (5-APB) on the dopamine transporter and 5-HT2-dependent vasoconstriction in the rat | https://www.ncbi.nlm.nih.gov/pubmed/24012617?dopt=Abstract</ref><ref>Neurochemical profiles of some novel psychoactive substances | http://www.sciencedirect.com/science/article/pii/S0014299912010114</ref> It has also been speculated that 5-APB is a [[monoamine]] [[releasing agent]].

This means it effectively boosts the levels of the serotonin, norepinephrine and dopamine neurotransmitters in the brain by binding to and partially blocking the transporter proteins that normally remove those monoamines from the synaptic cleft. This allows dopamine and norepinephrine to accumulate within the brain, resulting in [[stimulation|stimulating]] and [[physical euphoria|euphoric]] effects.

==Subjective effects==

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--APB is a triple [[reuptake inhibitor]] for [[norepinephrine]], [[dopamine]] and [[serotonin]], as well as being an [[agonist]] for the [[Serotonin#The_5-HT_system|5-HT<sub>2A</sub>]] and [[Serotonin#The_5-HT_system|5-HT<sub>2B</sub>]] [[receptor]]s. It has also been speculated from the structure activity relationship(SAR) that 5-APB is a monoamine [[releasing agent]].
+-APB is a triple [[reuptake inhibitor]] for [[norepinephrine]], [[dopamine]] and [[serotonin]], as well as being an [[agonist]] for the [[Serotonin#The_5-HT_system|5-HT<sub>2A</sub>]] and [[Serotonin#The_5-HT_system|5-HT<sub>2B</sub>]] [[receptor]]s.<ref>The effects of benzofury (5-APB) on the dopamine transporter and 5-HT2-dependent vasoconstriction in the rat | https://www.ncbi.nlm.nih.gov/pubmed/24012617?dopt=Abstract</ref><ref>Neurochemical profiles of some novel psychoactive substances | http://www.sciencedirect.com/science/article/pii/S0014299912010114</ref> It has also been speculated that 5-APB is a [[monoamine]] [[releasing agent]].
+This means it effectively boosts the levels of the serotonin, norepinephrine and dopamine neurotransmitters in the brain by binding to and partially blocking the transporter proteins that normally remove those monoamines from the synaptic cleft. This allows dopamine and norepinephrine to accumulate within the brain, resulting in [[stimulation|stimulating]] and [[physical euphoria|euphoric]] effects.
 ==Subjective effects==