5-APB: Difference between revisions

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==Pharmacology==

{~~{pharmacology}~~}

{| class="wikitable"

5-APB is a triple reuptake inhibitor(TRI) with Ki values of 180, 265 and 811 nM for ~~NET~~, ~~DAT~~ and ~~SERT~~ respectively, as well as being ~~an agonist for the 5~~-HT2A ~~and 5~~-HT2B ~~receptors~~ (Ki of 14nM at 5-HT2B). It has also been speculated from the structure activity relationship(SAR) that 5-APB is a monoamine releasing agent.<ref>https://en.wikipedia.org/wiki/5-APB</ref>

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! Neurotransmitters !! Ki values

|-

| [[Norepinephrine]] || 180

|-

| [[Dopamine]] || 265

|-

| [[Serotonin]] || 811

|}

5-APB is a triple [[reuptake inhibitor]](TRI) with Ki values of 180, 265 and 811 nM for [[norepinephrine]], [[dopamine]] and [[serotonin]] respectively, as well as being an [[agonist]] for the [[Serotonin#The_5-HT_system|5-HT2A]] and [[Serotonin#The_5-HT_system|5-HT2B]] [[receptor]]s (Ki of 14nM at 5-HT2B). It has also been speculated from the structure activity relationship(SAR) that 5-APB is a monoamine releasing agent.<ref>https://en.wikipedia.org/wiki/5-APB</ref>

==Subjective effects==

The effects listed below are based upon the [[subjective effects index]] and personal experiences of [[PsychonautWiki]] [[Special:TopUsers|contributors]]. The listed effects will rarely (if ever) occur all at once, but heavier dosages will increase the chances and are more likely to induce a full range of effects.

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 ==Pharmacology==
-{{pharmacology}}
+{| class="wikitable"
--APB is a triple reuptake inhibitor(TRI) with K<sub>i</sub> values of 180, 265 and 811 nM for NET, DAT and SERT respectively, as well as being an agonist for the 5-HT<sub>2A</sub> and 5-HT<sub>2B</sub> receptors (K<sub>i</sub> of 14nM at 5-HT<sub>2B</sub>). It has also been speculated from the structure activity relationship(SAR) that 5-APB is a monoamine releasing agent.<ref>https://en.wikipedia.org/wiki/5-APB</ref>
+|-
+! Neurotransmitters !! K<sub>i</sub> values
+|-
+| [[Norepinephrine]] || 180
+|-
+| [[Dopamine]] || 265
+|-
+| [[Serotonin]] || 811
+|}
+-APB is a triple [[reuptake inhibitor]](TRI) with K<sub>i</sub> values of 180, 265 and 811 nM for [[norepinephrine]], [[dopamine]] and [[serotonin]] respectively, as well as being an [[agonist]] for the [[Serotonin#The_5-HT_system|5-HT<sub>2A</sub>]] and [[Serotonin#The_5-HT_system|5-HT<sub>2B</sub>]] [[receptor]]s (K<sub>i</sub> of 14nM at 5-HT<sub>2B</sub>). It has also been speculated from the structure activity relationship(SAR) that 5-APB is a monoamine releasing agent.<ref>https://en.wikipedia.org/wiki/5-APB</ref>
 ==Subjective effects==
 The effects listed below are based upon the [[subjective effects index]] and personal experiences of [[PsychonautWiki]] [[Special:TopUsers|contributors]]. The listed effects will rarely (if ever) occur all at once, but heavier dosages will increase the chances and are more likely to induce a full range of effects.