5-APB: Difference between revisions

Line 11:

5-APB is a triple reuptake inhibitor(TRI) with Ki values of 180, 265 and 811 nM for NET, DAT and SERT respectively, as well as being an agonist for the 5-HT2A and 5-HT2B receptors (Ki of 14nM at 5-HT2B). It has also been speculated from the structure activity relationship(SAR) that 5-APB is a monoamine releasing agent.<ref>https://en.wikipedia.org/wiki/5-APB</ref>

==Subjective effects==

The effects listed below are based upon the [[subjective effects index]] and personal experiences of [[PsychonautWiki]] [[Special:TopUsers|contributors]]. The listed effects will rarely (if ever) occur all at once, but heavier dosages will increase the chances and are more likely to induce a full range of effects.

===Physical effects===

*'''[[Effect::Stimulation]]'''

*'''[[Effect::Increased heart rate]]'''

*'''[[Effect::Dehydration]]'''

*'''[[Effect::Appetite suppression]]'''

*'''[[Effect::Nausea]]'''

*'''[[Effect::Temporary erectile dysfunction]]'''

*'''[[Effect::Increased perspiration]]'''

===Cognitive effects===

*'''[[Effect::Empathy, love, and sociability enhancement]]'''

*'''[[Effect::Focus enhancement]]'''

*'''[[Effect::Thought acceleration]]'''

*'''[[Effect::Analysis enhancement]]'''

*'''[[Effect::Wakefulness]]'''

*'''[[Effect::Memory enhancement]]'''

*'''[[Effect::Motivation enhancement]]'''

*'''[[Effect::Cognitive euphoria|Euphoria]]'''

*'''[[Effect::Compulsive redosing]]'''

===Visual effects===

*'''[[Effect::Acuity enhancement]]'''

===After effects===

The effects which occur during the [[offset]] of a [[stimulant]] experience generally feel negative and uncomfortable in comparison to the effects which occurred during its [[peak]]. This is often referred to as a "comedown" and occurs because of [[neurotransmitter]] depletion. Its effects commonly include:

*'''[[Effect::Cognitive fatigue]]'''

*'''[[Effect::Thought deceleration]]'''

*'''[[Effect::Anxiety]]'''

*'''[[Effect::Depression]]'''

*'''[[Effect::Wakefulness]]'''

*'''[[Effect::Irritability]]'''

==Toxicity and harm potential==

@@ Line 11: / Line 11: @@
 {{pharmacology}}
 -APB is a triple reuptake inhibitor(TRI) with K<sub>i</sub> values of 180, 265 and 811 nM for NET, DAT and SERT respectively, as well as being an agonist for the 5-HT<sub>2A</sub> and 5-HT<sub>2B</sub> receptors (K<sub>i</sub> of 14nM at 5-HT<sub>2B</sub>). It has also been speculated from the structure activity relationship(SAR) that 5-APB is a monoamine releasing agent.<ref>https://en.wikipedia.org/wiki/5-APB</ref>
+==Subjective effects==
+The effects listed below are based upon the [[subjective effects index]] and personal experiences of [[PsychonautWiki]] [[Special:TopUsers|contributors]]. The listed effects will rarely (if ever) occur all at once, but heavier dosages will increase the chances and are more likely to induce a full range of effects.
+===Physical effects===
+*'''[[Effect::Stimulation]]'''
+*'''[[Effect::Increased heart rate]]'''
+*'''[[Effect::Dehydration]]'''
+*'''[[Effect::Appetite suppression]]'''
+*'''[[Effect::Nausea]]'''
+*'''[[Effect::Temporary erectile dysfunction]]'''
+*'''[[Effect::Increased perspiration]]'''
+===Cognitive effects===
+*'''[[Effect::Empathy, love, and sociability enhancement]]'''
+*'''[[Effect::Focus enhancement]]'''
+*'''[[Effect::Thought acceleration]]'''
+*'''[[Effect::Analysis enhancement]]'''
+*'''[[Effect::Wakefulness]]'''
+*'''[[Effect::Memory enhancement]]'''
+*'''[[Effect::Motivation enhancement]]'''
+*'''[[Effect::Cognitive euphoria|Euphoria]]'''
+*'''[[Effect::Compulsive redosing]]'''
+===Visual effects===
+*'''[[Effect::Acuity enhancement]]'''
+===After effects===
+The effects which occur during the [[offset]] of a [[stimulant]] experience generally feel negative and uncomfortable in comparison to the effects which occurred during its [[peak]]. This is often referred to as a "comedown" and occurs because of [[neurotransmitter]] depletion. Its effects commonly include:
+*'''[[Effect::Cognitive fatigue]]'''
+*'''[[Effect::Thought deceleration]]'''
+*'''[[Effect::Anxiety]]'''
+*'''[[Effect::Depression]]'''
+*'''[[Effect::Wakefulness]]'''
+*'''[[Effect::Irritability]]'''
 ==Toxicity and harm potential==