Research chemicals: Difference between revisions

Pharmacological deaths are fatalities caused by the direct action of the chemical in the body and do not include deaths as a result of inebriated behavior.

*'''[[AMT]]''' - Deaths from AMT are rare<ref name="amt">AMT (Alphamethyltryptamine, IT-290) Fatalities / Deaths by Erowid | https://www.erowid.org/chemicals/amt/amt_death.shtml</ref><ref name="amt2">Boland DM, Andollo W, Hime GW, Hearn WL. “Fatality due to acute alpha-methyltryptamine intoxication”. J Anal Toxicol. 2005 Jul-Aug;29(5):394-7. | https://www.erowid.org/references/refs_view.php?ID=6603</ref> but, as a powerful [[monoamine]] [[reuptake inhibitor]] (MRI), injury could occur when excessive doses are taken or when it is taken with drugs such as [[MAOIs]], [[RIMA]]s, [[stimulants]] and any substance which act as a [[releasing agent]] or [[reuptake inhibitor]] of [[neurotransmitters]] such as [[serotonin]] and [[dopamine]].<ref>Monoamine oxidase inhibitors, opioid analgesics and serotonin toxicity | http://bja.oxfordjournals.org/content/95/4/434</ref>

*'''[[DOC]]''' - There is one reported death from DOC, however, the toxicology report hasn't been released nor has the presence of DOC been confirmed.<ref>DOC (2,5-Dimethoxy-ChloroAmphetamine) Fatalities / Deaths by Erowid | https://www.erowid.org/chemicals/doc/doc_death.shtml</ref>

====Dissociatives====

*'''[[MXP]]'''<ref>Elliott SP, Brandt SD, Wallach J, Morris H, Kavanagh PV. “First Reported Fatalities Associated with the 'Research Chemical' 2-Methoxydiphenidine”. J Anal Toxicol. 2015 May;39(4):287-293. | https://www.erowid.org/references/refs_view.php?ID=8804</ref>

*'''[[Acetylfentanyl]]''' - Between March 2013 and May 2013, 14 overdose deaths related to injected acetylfentanyl had occurred in Rhode Island. After confirming five overdoses in one county, including a fatality, Pennsylvania asked coroners and medical examiners across the state to screen for acetylfentanyl, which led to 50 confirmed fatalities and five non-fatal overdoses statewide in 2013.<ref>Ogilvie, Laurie, Christina Stanley, Lauren Lewis, Molly Boyd, Matthew Lozier, Matthew Lozier. "Notes from the Field: Acetyl Fentanyl Overdose Fatalities — Rhode Island, March–May 2013". cdc.gov. Center for Disease Control and Prevention. Retrieved 11 November 2013. | http://www.cdc.gov/mmwr/preview/mmwrhtml/mm6234a5.htm</ref><ref>Pennsylvania Department of Drug and Alcohol Programs. "Department of Drug and Alcohol Programs warns about acetyl fentanyl: drug caused at least 50 fatalities in 2013 in Pennsylvania.". Pennsylvania Department of Drug and Alcohol Programs. | http://www.pa.gov/portal/server.pt/document/1345188/department_of_drug_and_alcohol_programs_warns_about_acetyl_fentanyl</ref> Another 5 deaths were reported in Jefferson Parish, New Orleans,<ref> Grunfeld, David (November 1, 2013). "Couple found dead in Old Metairie home killed by lethal new synthetic drug". NOLA.com | The Times-Picayune. Retrieved 28 March 2014. | http://www.nola.com/crime/index.ssf/2013/10/couple_found_dead_in_old_metai.html</ref> along with three more in North Carolina.<ref> "DHHS Issues Health Advisory for Deadly New Synthetic Drug". NC DHHS Press Releases. North Carolina Department of Health and Human Services. Retrieved 27 August 2014. | http://www.ncdhhs.gov/news/press-releases/dhhs-issues-health-advisory-deadly-new-synthetic-drug</ref>

*'''[[AH-7921]]'''- In a 2014 study which investigated nine fatalities in which AH-7921 was involved, it was concluded that poly-drug use was not a major contributing factor for the deaths and that a more important factor was the person's tolerance to opiates, which led to an overdose when the drug was taken in excessive amounts.<ref>Fatal Intoxications Associated with the Designer Opioid AH-7921 | http://jat.oxfordjournals.org/content/38/8/599.full</ref>