2M2B: Difference between revisions

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==Toxicity and harm potential==

~~Little is known about the~~ long-term effects of ~~2-methyl-2-butanol~~ use. As it cannot be metabolized into aldehydes ~~it is not expected to be as hepatoxic as ethanol~~.<ref>http://www.mhhe.com/physsci/chemistry/carey/student/olc/ch15oxidationalcohols.html</ref>

The toxicity and long-term health effects of recreational 2m2b use do not seem to have been studied in any scientific context and the [[Toxicity::exact toxic dosage is unknown]] although the lowest recorded fatal dose in a human is 30mL.<ref>http://www.toxnet.nlm.nih.gov/cgi-bin/sis/search/a?dbs+hsdb:@term+@DOCNO+5005</ref> However, 2m2b is expected to be less toxic than ethanol as it cannot be metabolized into aldehydes in the same way.<ref>http://www.mhhe.com/physsci/chemistry/carey/student/olc/ch15oxidationalcohols.html</ref> Anecdotal evidence from people who have tried 2m2b within the community suggest that there do not seem to be any negative health effects attributed to simply trying this drug at low to moderate doses by itself and using it sparingly (but nothing can be completely guaranteed).

~~===Lethal dosage===~~

It is strongly recommended that one use [[responsible drug use|harm reduction practices]] when using this drug.

~~The lowest recorded fatal dose in a human~~ is 30mL.<ref>http://www.toxnet.nlm.nih.gov/cgi-bin/sis/search/a?dbs+hsdb:@term+@DOCNO+5005</ref> The oral LD50 in rats has been found to be about 1000mg/kg;<ref>Soehring, K.; Frey, H. H.; Endres, G. (1955). "Relations between constitution and effect of tertiary alcohols". Arzneimittel-Forschung 5 (4): 161–165. PMID 14389140</ref> however, this ~~does not necessarily carry over to humans. Doses large enough to induce a coma may allow aspiration of vomit which is a medical emergency~~.

~~It is strongly recommended that one use [[responsible drug use|harm reduction practices]] when using this drug.~~

===Tolerance and addiction potential===

As with any other GABA receptor agonist, repeated use and increasing tolerance will eventually result in a withdrawal syndrome upon abrupt discontinuation resembling alcohol, barbiturate, or [[Benzodiazepine#Discontinuation|benzodiazepine withdrawal]], up to and including delirium tremens ("the shakes"). The chronic use of this compound can be considered [[Addiction potential::moderately addictive with a high potential for abuse]] and is capable of causing psychological dependence among certain users. When addiction has developed, cravings and [[withdrawal effects]] may occur if a person suddenly stops their usage.

@@ Line 37: / Line 37: @@
 ==Toxicity and harm potential==
-Little is known about the long-term effects of 2-methyl-2-butanol use. As it cannot be metabolized into aldehydes it is not expected to be as hepatoxic as ethanol.<ref>http://www.mhhe.com/physsci/chemistry/carey/student/olc/ch15oxidationalcohols.html</ref>
+The toxicity and long-term health effects of recreational 2m2b use do not seem to have been studied in any scientific context and the [[Toxicity::exact toxic dosage is unknown]] although the lowest recorded fatal dose in a human is 30mL.<ref>http://www.toxnet.nlm.nih.gov/cgi-bin/sis/search/a?dbs+hsdb:@term+@DOCNO+5005</ref> However, 2m2b is expected to be less toxic than ethanol as  it cannot be metabolized into aldehydes in the same way.<ref>http://www.mhhe.com/physsci/chemistry/carey/student/olc/ch15oxidationalcohols.html</ref> Anecdotal evidence from people who have tried 2m2b within the community suggest that there do not seem to be any negative health effects attributed to simply trying this drug at low to moderate doses by itself and using it sparingly (but nothing can be completely guaranteed).
-===Lethal dosage===
+It is strongly recommended that one use [[responsible drug use|harm reduction practices]] when using this drug.
-The lowest recorded fatal dose in a human is 30mL.<ref>http://www.toxnet.nlm.nih.gov/cgi-bin/sis/search/a?dbs+hsdb:@term+@DOCNO+5005</ref> The oral LD50 in rats has been found to be about 1000mg/kg;<ref>Soehring, K.; Frey, H. H.; Endres, G. (1955). "Relations between constitution and effect of tertiary alcohols". Arzneimittel-Forschung 5 (4): 161–165. PMID 14389140</ref> however, this does not necessarily carry over to humans. Doses large enough to induce a coma may allow aspiration of vomit which is a medical emergency.
-It is strongly recommended that one use [[responsible drug use|harm reduction practices]] when using this drug.
 ===Tolerance and addiction potential===
 As with any other GABA receptor agonist, repeated use and increasing tolerance will eventually result in a withdrawal syndrome upon abrupt discontinuation resembling alcohol, barbiturate, or [[Benzodiazepine#Discontinuation|benzodiazepine withdrawal]], up to and including delirium tremens ("the shakes"). The chronic use of this compound can be considered [[Addiction potential::moderately addictive with a high potential for abuse]] and is capable of causing psychological dependence among certain users. When addiction has developed, cravings and [[withdrawal effects]] may occur if a person suddenly stops their usage.