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NM-2-AI: Difference between revisions
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| ''[[ | | ''[[NM-2-AI/Summary|Summary sheet: NM-2-AI]]'' | ||
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''' | '''NM-2-AI''' ('''N-methyl-2,3-dihydro-1H-inden-2-amine''' / '''N-methyl-2-AI''') is a psychoactive drug and [[research chemical]] with [[psychoactive class::stimulant]] properties of the [[Chemical class::aminoindane]] chemical class. | ||
In comparison to the more prevalent close chemical relative known as [[2-AI]], this compound has a lower potency, a longer duration and very similar effects. Besides this, very little is known about this substance. It has recently become freely available through online [[research chemical]] vendors where it is sold as a [[designer drug]]. | In comparison to the more prevalent close chemical relative known as [[2-AI]], this compound has a lower potency, a longer duration and very similar effects. Besides this, very little is known about this substance. It has recently become freely available through online [[research chemical]] vendors where it is sold as a [[designer drug]]. | ||
==Chemistry== | ==Chemistry== | ||
NM-2-AI, or N-methyl-2-AI, is the N-methylated derivative of [[2-Aminoindane]] and is analogous to [[amphetamine]]. It features the R<sub>3</sub> terminal carbon of the propane chain of amphetamine bound to the benzene ring. This creates an indane, a bicycle containing a benzene ring fused to a pentane ring. The amino group 2-AI shares with amphetamine is bound to R<sub>2</sub> of the indane group. N-methyl-2-AI contains a methyl group bound to the amino group R<sub>N</sub> (for which it is named). | |||
==Pharmacology== | ==Pharmacology== | ||
Due to the lack of research regarding the substance, all discussion regarding the pharmacology of it is speculation purely based upon its structure and subjective effect similarities to other [[stimulant]]s such as [[amphetamine]], [[methamphetamine]] and [[2-FMA]]. It is speculated that | Due to the lack of research regarding the substance, all discussion regarding the pharmacology of it is speculation purely based upon its structure and subjective effect similarities to other [[stimulant]]s such as [[amphetamine]], [[methamphetamine]] and [[2-FMA]]. It is speculated that NM-2-AI most likely acts as both a [[dopamine]] and [[norepinephrine]] [[releasing agent]]. This means it effectively boosts the levels of the norepinephrine and dopamine neurotransmitters in the brain by binding to and partially blocking the transporter proteins that normally remove those monoamines from the synaptic cleft. This allows dopamine and norepinephrine to accumulate within the brain, resulting in [[stimulation|stimulating]] and [[physical euphoria|euphoric]] effects. | ||
==Subjective effects== | ==Subjective effects== | ||
The effects listed below are based upon the [[subjective effects index]] and personal experiences of [[PsychonautWiki]] [[Special:TopUsers|contributors]]. The listed effects will rarely (if ever) occur all at once, but heavier dosages will increase the chances and are more likely to induce a full range of effects. | The effects listed below are based upon the [[subjective effects index]] and personal experiences of [[PsychonautWiki]] [[Special:TopUsers|contributors]]. The listed effects will rarely (if ever) occur all at once, but heavier dosages will increase the chances and are more likely to induce a full range of effects. | ||
===Physical effects=== | ===Physical effects=== | ||
*'''[[Effect::Stimulation]]''' - In terms of its effects on the physical energy levels of the user, | *'''[[Effect::Stimulation]]''' - In terms of its effects on the physical energy levels of the user, NM-2-AI is usually considered to be energetic and stimulating in a fashion that is similar to that of [[amphetamine]] but stronger than that of [[modafinil]] or [[caffeine]]. It is similar yet distinct from the stimulation experienced on [[MDMA]], encouraging physical activities such as dancing, socializing, running, or cleaning. The particular style of stimulation which NM-2-AI presents can be described as forced. This means that at higher doses, it becomes difficult or impossible to keep still as jaw clenching, involuntarily bodily shakes and vibrations become present, resulting in extreme shaking of the entire body, unsteadiness of the hands, and a general lack of motor control. | ||
*'''[[Effect::Increased heart rate]]''' | *'''[[Effect::Increased heart rate]]''' | ||
*'''[[Effect::Dehydration]]''' | *'''[[Effect::Dehydration]]''' | ||
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===Cognitive effects=== | ===Cognitive effects=== | ||
The cognitive effects of | The cognitive effects of NM-2-AI can be broken down into several components which progressively intensify proportional to dosage. The general head space of NM-2-AI is described by many as one of mental stimulation, increased focus, and euphoria. It contains a large number of typical [[stimulant]] cognitive effects. Although negative side effects are usually mild at low to moderate doses, they become increasingly likely to manifest themselves with higher amounts or extended usage. This particularly holds true during the [[offset]] of the experience. | ||
The most prominent of these cognitive effects generally include: | The most prominent of these cognitive effects generally include: | ||
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==Toxicity and harm potential== | ==Toxicity and harm potential== | ||
{{Main|Research chemicals#Toxicity and harm potential}} | {{Main|Research chemicals#Toxicity and harm potential}} | ||
The toxicity and long-term health effects of recreational | The toxicity and long-term health effects of recreational NM-2-AI use do not seem to have been studied in any scientific context and the [[Toxicity::exact toxic dosage is unknown]]. This is because NM-2-AI has very little history of human usage. Anecdotal evidence from people who have tried NM-2-AI within the community suggest that there do not seem to be any negative health effects attributed to simply trying this drug at low to moderate doses by itself and using it sparingly (but nothing can be completely guaranteed). | ||
It is strongly recommended that one use [[responsible use|harm reduction practices]] when using this drug. | It is strongly recommended that one use [[responsible use|harm reduction practices]] when using this drug. | ||
===Tolerance and addiction potential=== | ===Tolerance and addiction potential=== | ||
As with other [[stimulants]], the chronic use of | As with other [[stimulants]], the chronic use of NM-2-AI can be considered [[Addiction potential::moderately addictive with a high potential for abuse]] and is capable of causing psychological dependence among certain users. When addiction has developed, cravings and [[withdrawal effects]] may occur if a person suddenly stops their usage. | ||
Tolerance to many of the effects of | Tolerance to many of the effects of NM-2-AI [[Time to full tolerance::develops with prolonged and repeated use]]. This results in users having to administer increasingly large doses to achieve the same effects. After that, it takes about [[Time to half tolerance::3 - 7 days]] for the tolerance to be reduced to half and [[Time to zero tolerance::1 - 2 weeks]] to be back at baseline (in the absence of further consumption). NM-2-AI presents cross-tolerance with [[Cross-tolerance::all [[dopamine]]rgic [[stimulants]]]], meaning that after the consumption of 2AI all [[stimulant]]s will have a reduced effect. | ||
===Psychosis=== | ===Psychosis=== | ||
{{Main|Stimulant psychosis}} | {{Main|Stimulant psychosis}} | ||
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===Dangerous interactions=== | ===Dangerous interactions=== | ||
{{DangerousInteractions/Intro}} | {{DangerousInteractions/Intro}} | ||
*'''[[Stimulants]]''' - | *'''[[Stimulants]]''' - NM-2-AI can be potentially dangerous in combination with other [[stimulants]] as it can [[increased heart rate|increase one's heart rate]] and [[increased blood pressure|blood pressure]] to dangerous levels. | ||
{{DangerousInteractions/Stimulants}} | {{DangerousInteractions/Stimulants}} | ||
*'''[[MDMA]]''' - The neurotoxic effects of MDMA may be increased when combined with [[amphetamine]] and other stimulants. | *'''[[MDMA]]''' - The neurotoxic effects of MDMA may be increased when combined with [[amphetamine]] and other stimulants. | ||
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==Legal issues== | ==Legal issues== | ||
{{legalStub}} | {{legalStub}} | ||
NM-2-AI is currently believed to be a grey area compound within most parts of the world. This means that it is not known to be specifically illegal within any country but people may still be charged for its possession under certain circumstances such as under analogue laws and with intent to sell or consume. | |||
==See also== | ==See also== | ||
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*[[Methamphetamine]] | *[[Methamphetamine]] | ||
==External links== | ==External links== | ||
*[[https://en.wikipedia.org/wiki/NM-2-AI | *[[https://en.wikipedia.org/wiki/NM-2-AI NM-2-AI]] | ||
==References== | ==References== | ||
<references /> | <references /> | ||
[[Category:Substance]][[Category:Stimulant]][[Category:Psychoactive substance]][[Category:Aminoindane]] | [[Category:Substance]][[Category:Stimulant]][[Category:Psychoactive substance]][[Category:Aminoindane]] | ||