PCP: Difference between revisions

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==Toxicity and harm potential==

===Psychosis===

PCP has been reported to cause [[psychosis]] and mania at a significantly higher rate than other [[dissociatives]] like [[ketamine]], [[diphenidine]], or [[MXE]]. There are multiple scientific papers which describe states of psychosis, mania, and/or delirium occurring after large doses of the drug were ingested. In one initial human trial, it was reported that one-sixth of the patients who had received anaesthetic doses became psychotic.<ref name="one">http://archives.drugabuse.gov/pdf/monographs/21.pdf | Luisada, Paul V., M.D. "The Phencyclidine Psychosis: Phenomenology and Treatment." Phencyclidine (PCP) Abuse: An Appraisal. Rockville, Maryland: National Institute on Drug Abuse, 1978. pg. 241.</ref><ref name="two">Tasman, Allan, Jerald Kay, and Jeffrey A. Lieberman. Psychiatry. Chichester: John Wiley & Sons, 2003. Google Books. Wiley. Web. <https://books.google.com/books?id=l2KRBgAAQBAJ&pg=PT4957&lpg=PT4957&dq=Greifenstein+et+al.+1958%29.&source=bl&ots=s5CFdAfMzc&sig=GzsOq_N-V1qtahxyyHnKMJceEj0&hl=en&sa=X&ved=0ahUKEwji0pWTjNLKAhUBaD4KHTfqD0sQ6AEIHDAA#v=onepage&q=Greifenstein%20et%20al.%201958%29.&f=false>.</ref> In some cases, it took up to a week or more to resolve.

It is strongly recommended that one use extreme caution and [[responsible use|harm reduction]] practices when using this drug. Users should avoid taking the drug multiple days in a row or becoming addicted to it as this increases the risk of severe adverse effects. The recommended dosage range should not be exceeded as high doses can trigger these effects as well. Users should start with extremely low doses and work their way up as slowly as possible. [[Volumetric liquid dosing|Volumetric liquid dosing]] should preferably be used due to the drug's potency; most standard milligram scales cannot accurately weigh out doses below 10-15mg.<ref>3-MeO-PCP (Tripsit) | https://wiki.tripsit.me/wiki/3-MeO-PCP</ref> [[Compulsive redosing]] before one has fully sobered up is not recommended and can result in too high of a dose.

Due to the risk of psychosis, it is not recommended to combine this drug with other substances, especially [[stimulants]], [[psychedelics]], or other [[dissociatives]] like [[MXE]]. Independent research should always be done to ensure that a combination of two or more substances is safe before consumption.

===Tolerance and addiction potential===

In terms of PCP tolerance, similar to any other NMDA antagonist, this can take weeks to build up for some, but for others it can take merely a single night of heavy use. Once a physical tolerance to PCP has set itself in, it can often take a month or more to reset itself.

@@ Line 98: / Line 98: @@
 ==Toxicity and harm potential==
+===Psychosis===
+PCP has been reported to cause [[psychosis]] and mania at a significantly higher rate than other [[dissociatives]] like [[ketamine]], [[diphenidine]], or [[MXE]]. There are multiple scientific papers which describe states of psychosis, mania, and/or delirium occurring after large doses of the drug were ingested. In one initial human trial, it was reported that one-sixth of the patients who had received anaesthetic doses became psychotic.<ref name="one">http://archives.drugabuse.gov/pdf/monographs/21.pdf | Luisada, Paul V., M.D. "The Phencyclidine Psychosis: Phenomenology and Treatment." Phencyclidine (PCP) Abuse: An Appraisal. Rockville, Maryland: National Institute on Drug Abuse, 1978. pg. 241.</ref><ref name="two">Tasman, Allan, Jerald Kay, and Jeffrey A. Lieberman. Psychiatry. Chichester: John Wiley & Sons, 2003. Google Books. Wiley. Web. <https://books.google.com/books?id=l2KRBgAAQBAJ&pg=PT4957&lpg=PT4957&dq=Greifenstein+et+al.+1958%29.&source=bl&ots=s5CFdAfMzc&sig=GzsOq_N-V1qtahxyyHnKMJceEj0&hl=en&sa=X&ved=0ahUKEwji0pWTjNLKAhUBaD4KHTfqD0sQ6AEIHDAA#v=onepage&q=Greifenstein%20et%20al.%201958%29.&f=false>.</ref> In some cases, it took up to a week or more to resolve.
+It is strongly recommended that one use extreme caution and [[responsible use|harm reduction]] practices when using this drug. Users should avoid taking the drug multiple days in a row or becoming addicted to it as this increases the risk of severe adverse effects. The recommended dosage range should not be exceeded as high doses can trigger these effects as well. Users should start with extremely low doses and work their way up as slowly as possible. [[Volumetric liquid dosing|Volumetric liquid dosing]] should preferably be used due to the drug's potency; most standard milligram scales cannot accurately weigh out doses below 10-15mg.<ref>3-MeO-PCP (Tripsit) | https://wiki.tripsit.me/wiki/3-MeO-PCP</ref> [[Compulsive redosing]] before one has fully sobered up is not recommended and can result in too high of a dose.
+Due to the risk of psychosis, it is not recommended to combine this drug with other substances, especially [[stimulants]], [[psychedelics]], or other [[dissociatives]] like [[MXE]]. Independent research should always be done to ensure that a combination of two or more substances is safe before consumption.
 ===Tolerance and addiction potential===
 In terms of PCP tolerance, similar to any other NMDA antagonist, this can take weeks to build up for some, but for others it can take merely a single night of heavy use. Once a physical tolerance to PCP has set itself in, it can often take a month or more to reset itself.