4F-MPH: Difference between revisions

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| ''[[4F-MPH/Summary|Summary sheet: 4F-MPH]]''

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'''4F-MPH''' ('''4'-fluoro-methylphenidate''') is an [[entactogenic]] [[stimulant]], [[substituted phenethylamine]], [[piperidine]], and close analog of [[methylphenidate]] (ritalin). The two substances have very similar pharmacological mechanisms but distinctively different subjective effects as ~~ethylphenidate~~ can be considered as significantly more euphoric and recreational in its experience. It also acts as a higher efficiency dopamine reuptake inhibitor than the closely related methylphenidate.<ref>Synthesis and pharmacology of potential cocaine antagonists. 2. Structure-activity relationship studies of aromatic ring-substituted methylphenidate analogs | https://www.ncbi.nlm.nih.gov/pubmed/8632426</ref><ref>Biochemical and behavioral characterization of novel methylphenidate analogs | https://www.ncbi.nlm.nih.gov/pubmed/11961053</ref><ref>Synthesis of methylphenidate analogues and their binding affinities at dopamine and serotonin transport sites | https://www.ncbi.nlm.nih.gov/pubmed/15026075</ref><ref>Quantitative structure-activity relationship studies of threo-methylphenidate analogs | https://www.ncbi.nlm.nih.gov/pubmed/20846865</ref><ref>Chemistry, Design, and Structure−Activity Relationship of Cocaine Antagonists | http://pubs.acs.org/doi/abs/10.1021/cr9700538</ref>.

'''4F-MPH''' ('''4'-fluoro-methylphenidate''') is an [[entactogenic]] [[stimulant]], [[substituted phenethylamine]], [[piperidine]], and close analog of [[methylphenidate]] (ritalin). The two substances have very similar pharmacological mechanisms but distinctively different subjective effects as 4F-MPH can be considered as significantly more euphoric and recreational in its experience. It also acts as a higher efficiency dopamine reuptake inhibitor than the closely related methylphenidate.<ref>Synthesis and pharmacology of potential cocaine antagonists. 2. Structure-activity relationship studies of aromatic ring-substituted methylphenidate analogs | https://www.ncbi.nlm.nih.gov/pubmed/8632426</ref><ref>Biochemical and behavioral characterization of novel methylphenidate analogs | https://www.ncbi.nlm.nih.gov/pubmed/11961053</ref><ref>Synthesis of methylphenidate analogues and their binding affinities at dopamine and serotonin transport sites | https://www.ncbi.nlm.nih.gov/pubmed/15026075</ref><ref>Quantitative structure-activity relationship studies of threo-methylphenidate analogs | https://www.ncbi.nlm.nih.gov/pubmed/20846865</ref><ref>Chemistry, Design, and Structure−Activity Relationship of Cocaine Antagonists | http://pubs.acs.org/doi/abs/10.1021/cr9700538</ref>.

4F-MPH has little to no history of human usage prior to its distribution online through research chemical vendors. It was initially developed as replacement for [[ethylphenidate]] which became illegal in the United Kingdom as of Friday 10th April 2015 due to a temporary blanket ban. Annecdotal reports are suggesting that it is considerably more potent with fewer uncomfortable side effects such as [[anxiety]], [[muscle spasms]] and [[compulsive redosing]].<ref>http://www.bluelight.org/vb/threads/770658-4-Fluoromethylphenidate-(4F-MPH)</ref>

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In terms of its tolerance, 4F-MPH can be used multiple days in a row for extended periods of time, but acute tolerance does exist and builds up gradually over repeated extended use. This results in the user requiring an increase in dosage to achieve the same effects.

4F-MPH has potential for abuse on par with that of [[amphetamine]] or [[MDMA]] due to its lack of significant tolerance, euphoric effects and action upon [[dopamine]] transporters~~. In comparison, the abuse and addiction potential of [[methylphenidate]] is considered as significantly lower than other dopaminergic [[stimulants]].~~

4F-MPH has potential for abuse on par with that of [[amphetamine]] or [[MDMA]] due to its lack of significant tolerance, euphoric effects and action upon [[dopamine]] transporters.

It is worth noting that the addiction potential is increased when 4F-MPH is crushed and [[Routes_of_administration#Insufflation|insufflated]] (snorted) or [[Routes_of_administration#Intravenous|injected]].

===Dangerous interactions===

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 | ''[[4F-MPH/Summary|Summary sheet: 4F-MPH]]''
 |}
-'''4F-MPH''' ('''4'-fluoro-methylphenidate''') is an [[entactogenic]] [[stimulant]], [[substituted phenethylamine]], [[piperidine]], and close analog of [[methylphenidate]] (ritalin). The two substances have very similar pharmacological mechanisms but distinctively different subjective effects as ethylphenidate can be considered as significantly more euphoric and recreational in its experience. It also acts as a higher efficiency dopamine reuptake inhibitor than the closely related methylphenidate.<ref>Synthesis and pharmacology of potential cocaine antagonists. 2. Structure-activity relationship studies of aromatic ring-substituted methylphenidate analogs | https://www.ncbi.nlm.nih.gov/pubmed/8632426</ref><ref>Biochemical and behavioral characterization of novel methylphenidate analogs | https://www.ncbi.nlm.nih.gov/pubmed/11961053</ref><ref>Synthesis of methylphenidate analogues and their binding affinities at dopamine and serotonin transport sites | https://www.ncbi.nlm.nih.gov/pubmed/15026075</ref><ref>Quantitative structure-activity relationship studies of threo-methylphenidate analogs | https://www.ncbi.nlm.nih.gov/pubmed/20846865</ref><ref>Chemistry, Design, and Structure−Activity Relationship of Cocaine Antagonists | http://pubs.acs.org/doi/abs/10.1021/cr9700538</ref>.
+'''4F-MPH''' ('''4'-fluoro-methylphenidate''') is an [[entactogenic]] [[stimulant]], [[substituted phenethylamine]], [[piperidine]], and close analog of [[methylphenidate]] (ritalin). The two substances have very similar pharmacological mechanisms but distinctively different subjective effects as 4F-MPH can be considered as significantly more euphoric and recreational in its experience. It also acts as a higher efficiency dopamine reuptake inhibitor than the closely related methylphenidate.<ref>Synthesis and pharmacology of potential cocaine antagonists. 2. Structure-activity relationship studies of aromatic ring-substituted methylphenidate analogs | https://www.ncbi.nlm.nih.gov/pubmed/8632426</ref><ref>Biochemical and behavioral characterization of novel methylphenidate analogs | https://www.ncbi.nlm.nih.gov/pubmed/11961053</ref><ref>Synthesis of methylphenidate analogues and their binding affinities at dopamine and serotonin transport sites | https://www.ncbi.nlm.nih.gov/pubmed/15026075</ref><ref>Quantitative structure-activity relationship studies of threo-methylphenidate analogs | https://www.ncbi.nlm.nih.gov/pubmed/20846865</ref><ref>Chemistry, Design, and Structure−Activity Relationship of Cocaine Antagonists | http://pubs.acs.org/doi/abs/10.1021/cr9700538</ref>.
 F-MPH has little to no history of human usage prior to its distribution online through research chemical vendors. It was initially developed as replacement for [[ethylphenidate]] which became illegal in the United Kingdom as of Friday 10th April 2015 due to a temporary blanket ban. Annecdotal reports are suggesting that it is considerably more potent with fewer uncomfortable side effects such as [[anxiety]], [[muscle spasms]] and [[compulsive redosing]].<ref>http://www.bluelight.org/vb/threads/770658-4-Fluoromethylphenidate-(4F-MPH)</ref>
@@ Line 43: / Line 43: @@
 In terms of its tolerance, 4F-MPH can be used multiple days in a row for extended periods of time, but acute tolerance does exist and builds up gradually over repeated extended use. This results in the user requiring an increase in dosage to achieve the same effects.
-F-MPH has potential for abuse on par with that of [[amphetamine]] or [[MDMA]] due to its lack of significant tolerance, euphoric effects and action upon [[dopamine]] transporters. In comparison, the abuse and addiction potential of [[methylphenidate]] is considered as significantly lower than other dopaminergic [[stimulants]].
+F-MPH has potential for abuse on par with that of [[amphetamine]] or [[MDMA]] due to its lack of significant tolerance, euphoric effects and action upon [[dopamine]] transporters.
-It is worth noting that the addiction potential is increased when 4F-MPH is crushed and [[Routes_of_administration#Insufflation|insufflated]] (snorted) or [[Routes_of_administration#Intravenous|injected]].
 ===Dangerous interactions===
 {{DangerousInteractions/Intro}}