Prochlorperazine: Difference between revisions

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'''Prochlorperazine''' ('''Compazine''', '''Stemzine''', '''Buccastem''', '''Stemetil''', '''Phenotil''') is a [[dopamine]] (D2) [[receptor]] [[antagonist]] that belongs to the [[phenothiazine]] class of [[antipsychotic]] agents that are used for the treatment of nausea and vertigo. It is also a highly potent typical antipsychotic and is 10–20× more potent than chlorpromazine. It is also used to treat migraine headaches.<ref>Husseini, A; Gianakos, D (February 2006). "The 15-Minute Visit". Patient Care 40: 9–10.</ref>

==Chemistry==

Prochlorperazine is a piperazine derivative of the phenothiazine class of organic compounds. Prochlorperazine contains a thiazine ring, a six-member ring which includes one nitrogen and one sulfur atom. The thiazine ring is fused to two benzene rings, creating a tricyclic phenothiazine. Prochlorperazine contains a chlorine atom bound to R2 of the phenothiazine group. Additionally, bound at R10 to the nitrogen atom of the structure, is a three carbon propyl chain. The propyl chain is bound at it's terminal carbon to a piperazine ring at R1. Piperazine is a six-membered saturated ring with two nitrogen atoms at positions 1 and 4. The piperazine ring of prochlorperazine is also substituted at R4 with a methyl group. Prochlorperazine is found in pills as a maleate. It is analagous to [[chlorpromazine]], another anti-psychotic phenothiazine.

Prochlorperazine is a piperazine derivative of the phenothiazine class of organic compounds. Prochlorperazine contains a thiazine ring, a six-member ring which includes one nitrogen and one sulfur atom. The thiazine ring is fused to two benzene rings, creating a tricyclic phenothiazine. Prochlorperazine contains a chlorine atom bound to R2 of the phenothiazine group. Additionally, bound at R10 to the nitrogen atom of the structure, is a three carbon propyl chain.

The propyl chain is bound at it's terminal carbon to a piperazine ring at R1. Piperazine is a six-membered saturated ring with two nitrogen atoms at positions 1 and 4. The piperazine ring of prochlorperazine is also substituted at R4 with a methyl group. Prochlorperazine is found in pills as a maleate. It is analagous to [[chlorpromazine]], another anti-psychotic phenothiazine.

==Pharmacology==

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 '''Prochlorperazine''' ('''Compazine''', '''Stemzine''', '''Buccastem''', '''Stemetil''', '''Phenotil''') is a [[dopamine]] (D2) [[receptor]] [[antagonist]] that belongs to the [[phenothiazine]] class of [[antipsychotic]] agents that are used for the treatment of nausea and vertigo. It is also a highly potent typical antipsychotic and is 10–20× more potent than chlorpromazine. It is also used to treat migraine headaches.<ref>Husseini, A; Gianakos, D (February 2006). "The 15-Minute Visit". Patient Care 40: 9–10.</ref>
 ==Chemistry==
-Prochlorperazine is a piperazine derivative of the phenothiazine class of organic compounds. Prochlorperazine contains a thiazine ring, a six-member ring which includes one nitrogen and one sulfur atom. The thiazine ring is fused to two benzene rings, creating a tricyclic phenothiazine. Prochlorperazine contains a chlorine atom bound to R<sub>2</sub> of the phenothiazine group. Additionally, bound at R<sub>10</sub> to the nitrogen atom of the structure, is a three carbon propyl chain. The propyl chain is bound at it's terminal carbon to a piperazine ring at R<sub>1</sub>. Piperazine is a six-membered saturated ring with two nitrogen atoms at positions 1 and 4. The piperazine ring of prochlorperazine is also substituted at R<sub>4</sub> with a methyl group. Prochlorperazine is found in pills as a maleate. It is analagous to [[chlorpromazine]], another anti-psychotic phenothiazine.
+Prochlorperazine is a piperazine derivative of the phenothiazine class of organic compounds. Prochlorperazine contains a thiazine ring, a six-member ring which includes one nitrogen and one sulfur atom. The thiazine ring is fused to two benzene rings, creating a tricyclic phenothiazine. Prochlorperazine contains a chlorine atom bound to R<sub>2</sub> of the phenothiazine group. Additionally, bound at R<sub>10</sub> to the nitrogen atom of the structure, is a three carbon propyl chain.
+The propyl chain is bound at it's terminal carbon to a piperazine ring at R<sub>1</sub>. Piperazine is a six-membered saturated ring with two nitrogen atoms at positions 1 and 4. The piperazine ring of prochlorperazine is also substituted at R<sub>4</sub> with a methyl group. Prochlorperazine is found in pills as a maleate. It is analagous to [[chlorpromazine]], another anti-psychotic phenothiazine.
 ==Pharmacology==