4F-MPH: Difference between revisions

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'''4F-MPH''' ('''4'-fluoro-methylphenidate''') is an [[entactogenic]] [[stimulant]], [[substituted phenethylamine]], [[piperidine]], and close analog of [[methylphenidate]] (ritalin). The two substances have very similar pharmacological mechanisms but distinctively different subjective effects as ethylphenidate can be considered as significantly more euphoric and recreational in its experience. It also acts as a higher efficiency dopamine reuptake inhibitor than the closely related methylphenidate.<ref>Synthesis and pharmacology of potential cocaine antagonists. 2. Structure-activity relationship studies of aromatic ring-substituted methylphenidate analogs | https://www.ncbi.nlm.nih.gov/pubmed/8632426</ref><ref>Biochemical and behavioral characterization of novel methylphenidate analogs | https://www.ncbi.nlm.nih.gov/pubmed/11961053</ref><ref>Synthesis of methylphenidate analogues and their binding affinities at dopamine and serotonin transport sites | https://www.ncbi.nlm.nih.gov/pubmed/15026075</ref><ref>Quantitative structure-activity relationship studies of threo-methylphenidate analogs | https://www.ncbi.nlm.nih.gov/pubmed/20846865</ref>~~[5]~~.

'''4F-MPH''' ('''4'-fluoro-methylphenidate''') is an [[entactogenic]] [[stimulant]], [[substituted phenethylamine]], [[piperidine]], and close analog of [[methylphenidate]] (ritalin). The two substances have very similar pharmacological mechanisms but distinctively different subjective effects as ethylphenidate can be considered as significantly more euphoric and recreational in its experience. It also acts as a higher efficiency dopamine reuptake inhibitor than the closely related methylphenidate.<ref>Synthesis and pharmacology of potential cocaine antagonists. 2. Structure-activity relationship studies of aromatic ring-substituted methylphenidate analogs | https://www.ncbi.nlm.nih.gov/pubmed/8632426</ref><ref>Biochemical and behavioral characterization of novel methylphenidate analogs | https://www.ncbi.nlm.nih.gov/pubmed/11961053</ref><ref>Synthesis of methylphenidate analogues and their binding affinities at dopamine and serotonin transport sites | https://www.ncbi.nlm.nih.gov/pubmed/15026075</ref><ref>Quantitative structure-activity relationship studies of threo-methylphenidate analogs | https://www.ncbi.nlm.nih.gov/pubmed/20846865</ref><ref>Chemistry, Design, and Structure−Activity Relationship of Cocaine Antagonists | http://pubs.acs.org/doi/abs/10.1021/cr9700538</ref>.

4F-MPH has little to no history of human usage prior to its distribution online through research chemical vendors. It was initially developed as replacement for [[ethylphenidate]] which became illegal in the United Kingdom as of Friday 10th April 2015 due to a temporary blanket ban. Annecdotal reports are suggesting that it is considerably more potent with fewer uncomfortable side effects such as [[anxiety]], [[muscle spasms]] and [[compulsive redosing]].<ref>http://www.bluelight.org/vb/threads/770658-4-Fluoromethylphenidate-(4F-MPH)</ref>

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==Pharmacology==

~~Although it has not been formally studied,~~ 4F-MPH ~~likely~~ acts as a [[dopamine]] [[reuptake inhibitor]] and [[norepinephrine]] [[reuptake inhibitor]], meaning it effectively boosts the levels of the norepinephrine and dopamine [[neurotransmitters]] in the brain by binding to and partially blocking the transporter proteins that normally remove those monoamines from the synaptic cleft. This allows dopamine and norepinephrine to accumulate within the brain, resulting in stimulating and euphoric effects.

4F-MPH acts as a [[dopamine]] [[reuptake inhibitor]] and [[norepinephrine]] [[reuptake inhibitor]], meaning it effectively boosts the levels of the norepinephrine and dopamine [[neurotransmitters]] in the brain by binding to and partially blocking the transporter proteins that normally remove those monoamines from the synaptic cleft. This allows dopamine and norepinephrine to accumulate within the brain, resulting in stimulating and euphoric effects.

==Subjective effects==

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==Legal issues==

4F-~~MPH~~ is ~~not yet~~ controlled ~~internationally and remains freely available through~~ the ~~use of online research chemical vendors~~. ~~This means that it is not known to be specifically illegal within any country~~, ~~but people may still be charged for its possession under certain circumstances such as under~~ analogue ~~laws and with intent to sell or consume~~.

*4-Fluromethylphenidate is a Schedule I controlled substance in the US state Alabama.<ref>Controlled substances, Schedule I, additional synthetic controlled substances and analogue substances included in, trafficking in controlled substance analogues, requisite weight increased, Secs. 13A-12-231, 20-2-23 am'd. | https://legiscan.com/AL/text/SB333/2014</ref>

==See also==

*[[Methylphenidate]]

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*[https://en.wikipedia.org/wiki/4-Fluoromethylphenidate 4F-MPH (Wikipedia)]

*[http://www.bluelight.org/vb/threads/770658-4-Fluoromethylphenidate-(4F-MPH) 4F-MPH (Bluelight)]

*

*[https://www.ukchemicalresearch.org/Thread-4-Fluoromethylphenidate-4F-MPH 4F-MPH (UK Chemical Research)]

==References==

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 {{proofread}}
 {{SubstanceBox/4F-MPH}}
-'''4F-MPH''' ('''4'-fluoro-methylphenidate''') is an [[entactogenic]] [[stimulant]], [[substituted phenethylamine]], [[piperidine]], and close analog of [[methylphenidate]] (ritalin). The two substances have very similar pharmacological mechanisms but distinctively different subjective effects as ethylphenidate can be considered as significantly more euphoric and recreational in its experience. It also acts as a higher efficiency dopamine reuptake inhibitor than the closely related methylphenidate.<ref>Synthesis and pharmacology of potential cocaine antagonists. 2. Structure-activity relationship studies of aromatic ring-substituted methylphenidate analogs | https://www.ncbi.nlm.nih.gov/pubmed/8632426</ref><ref>Biochemical and behavioral characterization of novel methylphenidate analogs | https://www.ncbi.nlm.nih.gov/pubmed/11961053</ref><ref>Synthesis of methylphenidate analogues and their binding affinities at dopamine and serotonin transport sites | https://www.ncbi.nlm.nih.gov/pubmed/15026075</ref><ref>Quantitative structure-activity relationship studies of threo-methylphenidate analogs | https://www.ncbi.nlm.nih.gov/pubmed/20846865</ref>[5].
+'''4F-MPH''' ('''4'-fluoro-methylphenidate''') is an [[entactogenic]] [[stimulant]], [[substituted phenethylamine]], [[piperidine]], and close analog of [[methylphenidate]] (ritalin). The two substances have very similar pharmacological mechanisms but distinctively different subjective effects as ethylphenidate can be considered as significantly more euphoric and recreational in its experience. It also acts as a higher efficiency dopamine reuptake inhibitor than the closely related methylphenidate.<ref>Synthesis and pharmacology of potential cocaine antagonists. 2. Structure-activity relationship studies of aromatic ring-substituted methylphenidate analogs | https://www.ncbi.nlm.nih.gov/pubmed/8632426</ref><ref>Biochemical and behavioral characterization of novel methylphenidate analogs | https://www.ncbi.nlm.nih.gov/pubmed/11961053</ref><ref>Synthesis of methylphenidate analogues and their binding affinities at dopamine and serotonin transport sites | https://www.ncbi.nlm.nih.gov/pubmed/15026075</ref><ref>Quantitative structure-activity relationship studies of threo-methylphenidate analogs | https://www.ncbi.nlm.nih.gov/pubmed/20846865</ref><ref>Chemistry, Design, and Structure−Activity Relationship of Cocaine Antagonists | http://pubs.acs.org/doi/abs/10.1021/cr9700538</ref>.
 F-MPH has little to no history of human usage prior to its distribution online through research chemical vendors. It was initially developed as replacement for [[ethylphenidate]] which became illegal in the United Kingdom as of Friday 10th April 2015 due to a temporary blanket ban. Annecdotal reports are suggesting that it is considerably more potent with fewer uncomfortable side effects such as [[anxiety]], [[muscle spasms]] and [[compulsive redosing]].<ref>http://www.bluelight.org/vb/threads/770658-4-Fluoromethylphenidate-(4F-MPH)</ref>
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 ==Pharmacology==
-Although it has not been formally studied, 4F-MPH likely acts as a [[dopamine]] [[reuptake inhibitor]] and [[norepinephrine]] [[reuptake inhibitor]], meaning it effectively boosts the levels of the norepinephrine and dopamine [[neurotransmitters]] in the brain by binding to and partially blocking the transporter proteins that normally remove those monoamines from the synaptic cleft. This allows dopamine and norepinephrine to accumulate within the brain, resulting in stimulating and euphoric effects.
+F-MPH acts as a [[dopamine]] [[reuptake inhibitor]] and [[norepinephrine]] [[reuptake inhibitor]], meaning it effectively boosts the levels of the norepinephrine and dopamine [[neurotransmitters]] in the brain by binding to and partially blocking the transporter proteins that normally remove those monoamines from the synaptic cleft. This allows dopamine and norepinephrine to accumulate within the brain, resulting in stimulating and euphoric effects.
 ==Subjective effects==
@@ Line 51: / Line 51: @@
 ==Legal issues==
-F-MPH is not yet controlled internationally and remains freely available through the use of online research chemical vendors. This means that it is not known to be specifically illegal within any country, but people may still be charged for its possession under certain circumstances such as under analogue laws and with intent to sell or consume.
+{{legalStub}}
+*4-Fluromethylphenidate is a Schedule I controlled substance in the US state Alabama.<ref>Controlled substances, Schedule I, additional synthetic controlled substances and analogue substances included in, trafficking in controlled substance analogues, requisite weight increased, Secs. 13A-12-231, 20-2-23 am'd. | https://legiscan.com/AL/text/SB333/2014</ref>
 ==See also==
 *[[Methylphenidate]]
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 *[https://en.wikipedia.org/wiki/4-Fluoromethylphenidate 4F-MPH (Wikipedia)]
 *[http://www.bluelight.org/vb/threads/770658-4-Fluoromethylphenidate-(4F-MPH) 4F-MPH (Bluelight)]
-*
+*[https://www.ukchemicalresearch.org/Thread-4-Fluoromethylphenidate-4F-MPH 4F-MPH (UK Chemical Research)]
 ==References==
 <references/>