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| ===Dangerous interactions=== | | ===Dangerous interactions=== |
| Although many drugs are safe on their own, they can become dangerous and even life-threatening when combined with other substances. The list below contains some common potentially dangerous combinations, but may not include all of them. Certain combinations may be safe in low doses of each but still increase the potential risk of death. Independent research should always be done to ensure that a combination of two or more substances is safe before consumption.
| | {{DangerousInteractions/Intro}} |
| ====='''General risk'''===== | | {{DangerousInteractions/Stimulants|self=[[cathinone]]s}} |
| *'''[[25x-NBOMe]]''' - Both the NBOMe series and amphetamine class induce powerful [[stimulation]]. Side effects such as [[thought loops]], [[seizures]], [[increased blood pressure]], [[vasoconstriction]], [[increased heart rate]], and heart failure (in extreme cases) may occur.
| | *'''[[MDMA]]''' - The neurotoxic effects of MDMA may be increased when combined with other stimulants. |
| *'''[[Alcohol]]''' - It is dangerous to combine alcohol, a [[depressant]], with [[stimulants]] due to the risk of excessive intoxication. Stimulants decrease the [[sedation|sedative]] effect of alcohol, which is the main factor most people consider when determining their level of intoxication. Once the stimulant wears off, the effects of alcohol will be significantly increased, leading to intensified [[disinhibition]] as well as [[Alcohol#Subjective effects|other effects]]. If combined, one should strictly limit themselves to only drinking a certain amount of alcohol per hour. | |
| *'''[[Cocaine]]''' - This combination will increase strain on the heart. | | *'''[[Cocaine]]''' - This combination will increase strain on the heart. |
| *'''[[DXM]]''' - This combination may cause [[increased heart rate]] and [[Anxiety#Panic attacks|panic attack]]s (for extreme cases).
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| *'''[[MDMA]]''' - The neurotoxic effects of [[MDMA]] may be increased when combined with [[amphetamine]]s.
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| *'''[[MXE]]''' - [[Increased heart rate]] and [[increased blood pressure|blood pressure]] may occur.
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| *'''[[Tramadol]]''' - This combination can increase the risk of [[seizures]].
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| | | ====[[Serotonin syndrome]] risk==== |
| ====='''[[Serotonin syndrome]] risk'''===== | | {{DangerousInteractions/SerotoninSyndrome}} |
| *'''[[MAOIs]]''' - Examples include [[syrian rue]] and [[banisteriopsis caapi]]'''.<ref>Monoamine oxidase inhibitors, opioid analgesics and serotonin toxicity | http://bja.oxfordjournals.org/content/95/4/434</ref>
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| *'''[[2C-T-2]]'''
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| *'''[[2C-T-7]]'''
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| *'''[[αMT]]'''
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| *'''[[5-HTP]]'''
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| ==Legal issues== | | ==Legal issues== |
