Antipsychotic: Difference between revisions

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'''Antipsychotics''' (also known as '''neuroleptics''' or '''major tranquilizers''')<ref>http://books.google.ca/books?id=Q4hG2gRhy7oC&pg=PA151</ref> are a class of psychiatric medication primarily used to manage [[psychosis]] (including [[Delusions|delusions]], hallucinations, or disordered thought), particularly in [[schizophrenia]] and bipolar disorder.

First generation antipsychotics, known as typical antipsychotics, were discovered in the 1950s. Most second generation drugs, ~~known as~~ atypical antipsychotics, have been developed more recently~~, although the~~ first atypical antipsychotic, [[clozapine]], was discovered in the 1950s and introduced clinically in the 1970s. Both generations of medication tend to block receptors in the brain's [[dopamine]] pathways but atypicals tend to act on [[serotonin]] receptors as well.

First generation antipsychotics, known as typical antipsychotics, were discovered in the 1950s. Most second generation drugs, called atypical antipsychotics, have been developed more recently. The first atypical antipsychotic, [[clozapine]], was discovered in the 1950s and introduced clinically in the 1970s. Both generations of medication tend to block receptors in the brain's [[dopamine]] pathways but atypicals tend to act on [[serotonin]] receptors as well.

Notable and relatively common adverse effects of antipsychotics include extrapyramidal symptoms (which involve motor control), hyperprolactinaemia (primarily in typicals), weight gain and metabolic abnormalities (mostly in atypicals).<ref name = "SCZ">{{cite web | url = http://emedicine.medscape.com/article/288259-overview | title = Schizophrenia | author = Frankenburg FR, Dunayevich E, Albucher RC, Talavera F | publisher = emedicine.medscape.com | accessdate = 2013-10-02 }}</ref>

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 '''Antipsychotics''' (also known as '''neuroleptics''' or '''major tranquilizers''')<ref>http://books.google.ca/books?id=Q4hG2gRhy7oC&pg=PA151</ref> are a class of psychiatric medication primarily used to manage [[psychosis]] (including [[Delusions|delusions]], hallucinations, or disordered thought), particularly in [[schizophrenia]] and bipolar disorder.
-First generation antipsychotics, known as typical antipsychotics, were discovered in the 1950s. Most second generation drugs, known as atypical antipsychotics, have been developed more recently, although the first atypical antipsychotic, [[clozapine]], was discovered in the 1950s and introduced clinically in the 1970s. Both generations of medication tend to block receptors in the brain's [[dopamine]] pathways but atypicals tend to act on [[serotonin]] receptors as well.
+First generation antipsychotics, known as typical antipsychotics, were discovered in the 1950s. Most second generation drugs, called atypical antipsychotics, have been developed more recently. The first atypical antipsychotic, [[clozapine]], was discovered in the 1950s and introduced clinically in the 1970s. Both generations of medication tend to block receptors in the brain's [[dopamine]] pathways but atypicals tend to act on [[serotonin]] receptors as well.
 Notable and relatively common adverse effects of antipsychotics include extrapyramidal symptoms (which involve motor control), hyperprolactinaemia (primarily in typicals), weight gain and metabolic abnormalities (mostly in atypicals).<ref name = "SCZ">{{cite web | url = http://emedicine.medscape.com/article/288259-overview | title = Schizophrenia | author = Frankenburg FR, Dunayevich E, Albucher RC, Talavera F | publisher = emedicine.medscape.com | accessdate = 2013-10-02 }}</ref>