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Dextrorphan (DXO) is an active metabolite of [[dextromethorphan]]. This means that DXM is metabolized in the body by o-demethylation through the CYP2D6 enzyme to form DXO. Both are active chemicals and contribute to the subjective effects experienced when active doses of DXM are consumed. The pharmacology of dextrorphan is similar to that of dextromethorphan (DXM). However, dextrorphan is much more potent as an [[NMDA receptor antagonist]] as well as essentially inactive as a [[serotonin]] [[reuptake inhibitor]].<ref>Psychotropic Effects of Dextromethorphan Are Altered by the CYP2D6 Polymorphism: A Pilot Study [http://journals.lww.com/psychopharmacology/pages/articleviewer.aspx?year=1998&issue=08000&article=00014&type=abstract]</ref> One Erowid user reported excessive itchiness accompanied by a "peaceful yet emotionless state" after 340mg of the substance was consumed. <ref> | |||
Dextrorphan (DXO) is an active metabolite of [[dextromethorphan]]. This means that DXM is metabolized in the body by o-demethylation through the CYP2D6 enzyme to form DXO | |||
"Erowid DXM Vault : An Unpleasant Exploration of DXO, by Student." Erowid DXM Vault : An Unpleasant Exploration of DXO, by Student. Erowid.org, 15 Sept. 2001. Web. 15 Apr. 2015 [https://www.erowid.org/chemicals/dxm/dxm_info3.shtml]</ref> | "Erowid DXM Vault : An Unpleasant Exploration of DXO, by Student." Erowid DXM Vault : An Unpleasant Exploration of DXO, by Student. Erowid.org, 15 Sept. 2001. Web. 15 Apr. 2015 [https://www.erowid.org/chemicals/dxm/dxm_info3.shtml]</ref> | ||