Harmala alkaloid: Difference between revisions

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==Pharmacology==

Harmala alkaloids are classed as [[MAOI]]s. This means that they inhibit the activity of monoamine oxidase metabolic enzymes of which two varieties exist; MOA-A and MOA-B. The alkaloids bind reversibly to the active site of the enzyme, inhibiting its endogenous function of destroying amine functions of neurotransmitters and externally administered centrally active drugs. This has the effect of potentiating and prolonging the central and peripheral activity of both neurotransmitters and a variety of drugs.

Harmala alkaloids are classed as [[MAOI]]s. This means that they inhibit the activity of monoamine oxidase metabolic enzymes of which two varieties exist: MOA-A and MOA-B. The alkaloids bind reversibly to the active site of the enzyme, inhibiting its endogenous function of destroying amine functions of neurotransmitters and externally administered centrally active drugs. This has the effect of potentiating and prolonging the central and peripheral activity of both neurotransmitters and a variety of drugs.

Harmala alkaloids are selective for MOA-A at reasonable doses and bind to the enzyme temporarily, so are classed as a [[RIMA|reversible inhibitor of monoamine-A]] ([[RIMA]]). At higher doses, they also begin to affect the MOA-B enzyme. Because of the reversible selectivity for MAO-A, harmala alkaloids are considered to be less dangerous in combination with food which contains [[tyramine]] and other substances with monoamine moieties which are reliant on monoamine oxidase for decomposition.

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 ==Pharmacology==
-Harmala alkaloids are classed as [[MAOI]]s. This means that they inhibit the activity of monoamine oxidase metabolic enzymes of which two varieties exist; MOA-A and MOA-B. The alkaloids bind reversibly to the active site of the enzyme, inhibiting its endogenous function of destroying amine functions of neurotransmitters and externally administered centrally active drugs. This has the effect of potentiating and prolonging the central and peripheral activity of both neurotransmitters and a variety of drugs.
+Harmala alkaloids are classed as [[MAOI]]s. This means that they inhibit the activity of monoamine oxidase metabolic enzymes of which two varieties exist: MOA-A and MOA-B. The alkaloids bind reversibly to the active site of the enzyme, inhibiting its endogenous function of destroying amine functions of neurotransmitters and externally administered centrally active drugs. This has the effect of potentiating and prolonging the central and peripheral activity of both neurotransmitters and a variety of drugs.
 Harmala alkaloids are selective for MOA-A at reasonable doses and bind to the enzyme temporarily, so are classed as a [[RIMA|reversible inhibitor of monoamine-A]] ([[RIMA]]). At higher doses, they also begin to affect the MOA-B enzyme. Because of the reversible selectivity for MAO-A, harmala alkaloids are considered to be less dangerous in combination with food which contains [[tyramine]] and other substances with monoamine moieties which are reliant on monoamine oxidase for decomposition.