Harmala alkaloid: Difference between revisions

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==Toxicity and harm potential==
==Toxicity and harm potential==
===Drug interactions===
===Drug interactions===
While safer than general [[MAOIs]], RIMAs still have highly dangerous and sometimes fatal interactions with many common drugs. In particular, they can cause serotonin syndrome or hypertensive crisis when combined with almost any antidepressant or stimulant, common migraine medications, certain herbs, or even most cold medicines (including decongestants, antihistamines, and cough syrup, nicotine, caffeine, etc). Sedatives are likely easier tolerated, but potentiation should be expected.
While safer than general [[MAOIs]], RIMAs still have highly dangerous and sometimes fatal interactions with many common drugs. In particular, they can cause [[serotonin syndrome]] or hypertensive crisis when combined with almost any [[antidepressant]], [[stimulant]], common migraine medications, certain herbs, most cold medicines (including decongestants, [[antihistamines]], and cough syrup), nicotine, caffeine, etc. Sedatives are likely easier tolerated, but potentiation should be expected.


===Lethal dosage===
===Lethal dosage===