3-FPM: Difference between revisions

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'''3'-Fluorophenmetrazine''' or '''3-FPM''' is a short-lived [[stimulant]] drug of the [[phenethylamine]] variety which has recently been made available online. The chemical had no history of human use prior to 2014 when it began being sold online through [[research chemical]] vendors. The drug is considered to be more subtle in its effects when compared to other stimulants and produces less nervousness, euphoria, and insomnia than drugs of the [[substituted amphetamine]] class.

'''3'-Fluorophenmetrazine''' or '''3-FPM''' is a short-lived [[stimulant]] drug of the [[phenethylamine]] variety which has recently been made available online. The chemical had no history of human use prior to 2014 when it began being sold online through [[research chemical]] vendors. The drug is considered to be more subtle in its effects when compared to other stimulants and produces less nervousness, euphoria, and insomnia than drugs of the [[substituted amphetamine]] class. It should be noted that 3-FPM was first named in scientific literature as '''PAL-593'''; using this name to search for information is more successful than using '3-FPM'.

==Chemistry==

3-FPM is a fluorinated derivative of phenmetrazine. It contains a [[phenethylamine]] skeleton in which the terminal amine is incorporated into a morpholine ring. This morpholine ring is a heterocyclic ring containing an amino and ether functional groups. 3-FPM is a cyclized analogue of ephedrine with the addition of a flourine group onto the number 3 carbon of the phenyl ring.

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3-FPM is a sympathomimetic drug which has stimulant effects when consumed. Its mechanism of action appears to function by acting as [[releasing agent]] for [[dopamine]], [[serotonin]], and [[norepinephrine]] in the central nervous system. This accumulation of [[neurotransmitters]] results in the experience of euphoric and stimulating effects. It has a higher affinity for all three types of receptor when compared to [[methylphenidate]]. Its parent compound, phenmetrazine, was previously used as an appetite suppressant, but has since been withdrawn from the market.

<br>Below is a table showing the '''3-FPM's''' affinity to dopamine (Da), serotonin(5HT) and noradrenaline (NAd) as well as the values of some other stimulants that are more common;

<br>[[File:KiCmpTab.jpg|400px]]

<br>However, despite being able to compare these values directly extrapolation of possible effects from simply viewing the affinity values of a compound is not very accurate but can be used to hypothesise about '''3-FPM's''' mechanism of action in-vivo.

==Subjective effects==

The effects listed below are based upon the [[subjective effects index]] and personal experiences of [[PsychonautWiki]] [[Special:TopUsers|contributors]]. The listed effects will rarely if ever occur all at once but heavier dosages will increase the chances and are more likely to induce a full range of effects.

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 {{SubstanceBox/3-FPM}}
 {{proofread}}
-'''3'-Fluorophenmetrazine''' or '''3-FPM''' is a short-lived [[stimulant]] drug of the [[phenethylamine]] variety which has recently been made available online. The chemical had no history of human use prior to 2014 when it began being sold online through [[research chemical]] vendors. The drug is considered to be more subtle in its effects when compared to other stimulants and produces less nervousness, euphoria, and insomnia than drugs of the [[substituted amphetamine]] class.
+'''3'-Fluorophenmetrazine''' or '''3-FPM''' is a short-lived [[stimulant]] drug of the [[phenethylamine]] variety which has recently been made available online. The chemical had no history of human use prior to 2014 when it began being sold online through [[research chemical]] vendors. The drug is considered to be more subtle in its effects when compared to other stimulants and produces less nervousness, euphoria, and insomnia than drugs of the [[substituted amphetamine]] class. It should be noted that 3-FPM was first named in scientific literature as '''PAL-593'''; using this name to search for information is more successful than using '3-FPM'.
 ==Chemistry==
 -FPM is a fluorinated derivative of phenmetrazine. It contains a [[phenethylamine]] skeleton in which the terminal amine is incorporated into a morpholine ring. This morpholine ring is a heterocyclic ring containing an amino and ether functional groups. 3-FPM is a cyclized analogue of ephedrine with the addition of a flourine group onto the number 3 carbon of the phenyl ring.
@@ Line 8: / Line 8: @@
 -FPM is a sympathomimetic drug which has stimulant effects when consumed. Its mechanism of action appears to function by acting as [[releasing agent]] for [[dopamine]], [[serotonin]], and [[norepinephrine]] in the central nervous system. This accumulation of [[neurotransmitters]] results in the experience of euphoric and stimulating effects. It has a higher affinity for all three types of receptor when compared to [[methylphenidate]]. Its parent compound, phenmetrazine, was previously used as an appetite suppressant, but has since been withdrawn from the market.
+<br>Below is a table showing the '''3-FPM's''' affinity to dopamine (Da), serotonin(5HT) and noradrenaline (NAd) as well as the values of some other stimulants that are more common;
+<br>[[File:KiCmpTab.jpg|400px]]
+<br>However, despite being able to compare these values directly extrapolation of possible effects from simply viewing the affinity values of a compound is not very accurate but can be used to hypothesise about '''3-FPM's''' mechanism of action in-vivo.
 ==Subjective effects==
 The effects listed below are based upon the [[subjective effects index]] and personal experiences of [[PsychonautWiki]] [[Special:TopUsers|contributors]]. The listed effects will rarely if ever occur all at once but heavier dosages will increase the chances and are more likely to induce a full range of effects.