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Reuptake inhibitor: Difference between revisions
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Alternatively, some reuptake inhibitors bind to allosteric sites and inhibit reuptake indirectly and noncompetitively. Several dissociative drugs have been shown to work this way, including [[Phencyclidine|PCP]] and related drugs [[ketamine]], and dizocilpine (MK-801). They appear to exert their reuptake inhibition by binding to allosteric sites on each of the respective monoamine transporters. In addition to their high affinity for the main site of the monoamine transporters, several competitive transporter substrates, such as [[cocaine]], have lower affinity for these allosteric sites as well. | Alternatively, some reuptake inhibitors bind to allosteric sites and inhibit reuptake indirectly and noncompetitively. Several dissociative drugs have been shown to work this way, including [[Phencyclidine|PCP]] and related drugs [[ketamine]], and dizocilpine (MK-801). They appear to exert their reuptake inhibition by binding to allosteric sites on each of the respective monoamine transporters. In addition to their high affinity for the main site of the monoamine transporters, several competitive transporter substrates, such as [[cocaine]], have lower affinity for these allosteric sites as well. | ||
==Types of | ==Types of reuptake inhibitors== | ||
*A '''selective reuptake inhibitor''' will inhibit the reuptake of a specific [[neurotransmitter]]. An example of this is the class of antidepressants known as selective serotonin reuptake inhibitors, or SSRIs. | *A '''selective reuptake inhibitor''' will inhibit the reuptake of a specific [[neurotransmitter]]. An example of this is the class of antidepressants known as selective serotonin reuptake inhibitors, or SSRIs. | ||
*A '''non-selective reuptake inhibitor''' will inhibit the reuptake of more than one type of [[neurotransmitter]]. An example of this is [[cocaine]], which acts as a serotonin-noradrenaline-dopamine reuptake inhibitor, or SNDRI. | *A '''non-selective reuptake inhibitor''' will inhibit the reuptake of more than one type of [[neurotransmitter]]. An example of this is [[cocaine]], which acts as a serotonin-noradrenaline-dopamine reuptake inhibitor, or SNDRI. | ||