This is an unofficial archive of PsychonautWiki as of 2025-08-11T15:14:44Z. Content on this page may be outdated, incomplete, or inaccurate. Please refer to the original page for the most up-to-date information.
Reuptake inhibitor: Difference between revisions
>Oskykins |
>Oskykins |
||
| Line 3: | Line 3: | ||
Most known reuptake inhibitors affect the monoamine neurotransmitters [[serotonin]], [[noradrenaline]] (and [[adrenaline]]), and [[dopamine]]. However there are also a number of pharmaceuticals and research chemicals that act as reuptake inhibitors for other neurotransmitters such as [[glutamate]], [[GABA]], glycine, adenosine, choline (the precursor of [[acetylcholine]]), and the endocannabinoids, among others. | Most known reuptake inhibitors affect the monoamine neurotransmitters [[serotonin]], [[noradrenaline]] (and [[adrenaline]]), and [[dopamine]]. However there are also a number of pharmaceuticals and research chemicals that act as reuptake inhibitors for other neurotransmitters such as [[glutamate]], [[GABA]], glycine, adenosine, choline (the precursor of [[acetylcholine]]), and the endocannabinoids, among others. | ||
==Mechanism of | ==Mechanism of action== | ||
[[File:Reuptake inhibitor.png|350px|thumb|right|The effect of reuptake inhibitors on the presynaptic neurone.]] | [[File:Reuptake inhibitor.png|350px|thumb|right|The effect of reuptake inhibitors on the presynaptic neurone.]] | ||
Standard reuptake inhibitors are believed to act simply as competitive substrates that work by binding directly to the plasmalemma transporter of the [[neurotransmitter]] in question. They occupy the transporter in place of the respective neurotransmitter and competitively block the neurotransmitter from being transported from the synapse into the presynaptic neurone. | Standard reuptake inhibitors are believed to act simply as competitive substrates that work by binding directly to the plasmalemma transporter of the [[neurotransmitter]] in question. They occupy the transporter in place of the respective neurotransmitter and competitively block the neurotransmitter from being transported from the synapse into the presynaptic neurone. | ||