Talk:Dextrorphan: Difference between revisions

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Dextrorphan (DXO) is ~~the pro-drug for~~ [[Dextromethorphan]]. This means that it is metabolized in the body ~~from DXM~~ to form DXO, both of which are active chemicals which contribute ~~towards~~ the ~~experience of~~ subjective effects. The pharmacology of dextrorphan is similar to that of dextromethorphan (DXM). However, dextrorphan is much more potent as an [[NMDA receptor antagonist]] as well as essentially inactive as a [[serotonin]] [[reuptake inhibitor]].<ref>Psychotropic Effects of Dextromethorphan Are Altered by the CYP2D6 Polymorphism: A Pilot Study [http://journals.lww.com/psychopharmacology/pages/articleviewer.aspx?year=1998&issue=08000&article=00014&type=abstract]</ref>

Dextrorphan (DXO) is an active metabolite of [[Dextromethorphan]]. This means that DXM is metabolized in the body by o-demethylation through the CYP2D6 enzyme to form DXO, both of which are active chemicals which contribute to the subjective effects experienced when active doses of DXM are consumed. The pharmacology of dextrorphan is similar to that of dextromethorphan (DXM). However, dextrorphan is much more potent as an [[NMDA receptor antagonist]] as well as essentially inactive as a [[serotonin]] [[reuptake inhibitor]].<ref>Psychotropic Effects of Dextromethorphan Are Altered by the CYP2D6 Polymorphism: A Pilot Study [http://journals.lww.com/psychopharmacology/pages/articleviewer.aspx?year=1998&issue=08000&article=00014&type=abstract]</ref> One Erowid user reported excessive itchiness accompanied by a "peaceful yet emotionless state." <ref>

"Erowid DXM Vault : An Unpleasant Exploration of DXO, by Student." Erowid DXM Vault : An Unpleasant Exploration of DXO, by Student. Erowid.org, 15 Sept. 2001. Web. 15 Apr. 2015 [https://www.erowid.org/chemicals/dxm/dxm_info3.shtml]</ref>

==See also==

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-Dextrorphan (DXO) is the pro-drug for [[Dextromethorphan]]. This means that it is metabolized in the body from DXM to form DXO, both of which are active chemicals which contribute towards the experience of subjective effects. The pharmacology of dextrorphan is similar to that of dextromethorphan (DXM). However, dextrorphan is much more potent as an [[NMDA receptor antagonist]] as well as essentially inactive as a [[serotonin]] [[reuptake inhibitor]].<ref>Psychotropic Effects of Dextromethorphan Are Altered by the CYP2D6 Polymorphism: A Pilot Study [http://journals.lww.com/psychopharmacology/pages/articleviewer.aspx?year=1998&issue=08000&article=00014&type=abstract]</ref>
+Dextrorphan (DXO) is an active metabolite of [[Dextromethorphan]]. This means that DXM is metabolized in the body by o-demethylation through the CYP2D6 enzyme to form DXO, both of which are active chemicals which contribute to the subjective effects experienced when active doses of DXM are consumed. The pharmacology of dextrorphan is similar to that of dextromethorphan (DXM). However, dextrorphan is much more potent as an [[NMDA receptor antagonist]] as well as essentially inactive as a [[serotonin]] [[reuptake inhibitor]].<ref>Psychotropic Effects of Dextromethorphan Are Altered by the CYP2D6 Polymorphism: A Pilot Study [http://journals.lww.com/psychopharmacology/pages/articleviewer.aspx?year=1998&issue=08000&article=00014&type=abstract]</ref> One Erowid user reported excessive itchiness accompanied by a "peaceful yet emotionless state." <ref>
+"Erowid DXM Vault : An Unpleasant Exploration of DXO, by Student." Erowid DXM Vault : An Unpleasant Exploration of DXO, by Student. Erowid.org, 15 Sept. 2001. Web. 15 Apr. 2015 [https://www.erowid.org/chemicals/dxm/dxm_info3.shtml]</ref>
 ==See also==