Dihydrocodeine: Difference between revisions

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Dihydrocodeine is also the original member and chemical base of a number of similar semi-synthetic opiates such as [[acetyldihydrocodeine]], [[dihydrocodeine enol acetate]], [[dihydroisocodeine]], [[nicocodeine]], and [[nicodicodeine]].
Dihydrocodeine is also the original member and chemical base of a number of similar semi-synthetic opiates such as [[acetyldihydrocodeine]], [[dihydrocodeine enol acetate]], [[dihydroisocodeine]], [[nicocodeine]], and [[nicodicodeine]].
==Chemistry==
==Chemistry==
Dihydrocodeine shares similar chemical structure to codeine but lacks the double bond. This results in a much more stable chemical structure, also affecting its metabolism. Dihydrocodeine can be synthesised from morphine by reduction of the 7,8-double bond. It readily converts to dihydromorphine with high yields (>95%).
Dihydrocodeine shares similar chemical structure to codeine, but lacks the double bond. This results in a much more stable chemical structure and also affects its metabolism. Dihydrocodeine can be synthesised from morphine by reduction of the 7,8-double bond. It readily converts to dihydromorphine with high yields (>95%).


==Pharmacology==
==Pharmacology==