Dihydrocodeine: Difference between revisions

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Dihydrocodeine is also the original member and chemical base of a number of similar semi-synthetic opiates such as [[acetyldihydrocodeine]], [[dihydrocodeine enol acetate]], [[dihydroisocodeine]], [[nicocodeine]], and [[nicodicodeine]].

==Chemistry==

~~{{Chemistry}}~~

Dihydrocodeine shares similar chemical structure to codeine but lacks the double bond. This results in a much more stable chemical structure, also affecting its metabolism. Dihydrocodeine can be synthesised from morphine by reduction of the 7,8-double bond. It readily converts to dihydromorphine with high yields (>95%).

==Pharmacology==

Dihydrocodeine produces effects that are typical of μ-opioid agonists which suggests that it is pharmacologically similar to more traditional opioids such as codiene and morphine. These all appear to mimic endogenous endorphins. Endorphins are responsible for analgesia (reducing pain), causing sleepiness, and feelings of pleasure. They can be released in response to pain, strenuous exercise, orgasm, or excitement. This mimicking of natural endorphins results in the drug's [[euphoric]], [[analgesic]] (pain relief), and [[anxiolytic]] (anti-anxiety) effects.

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 Dihydrocodeine is also the original member and chemical base of a number of similar semi-synthetic opiates such as [[acetyldihydrocodeine]], [[dihydrocodeine enol acetate]], [[dihydroisocodeine]], [[nicocodeine]], and [[nicodicodeine]].
 ==Chemistry==
-{{Chemistry}}
+Dihydrocodeine shares similar chemical structure to codeine but lacks the double bond. This results in a much more stable chemical structure, also affecting its metabolism. Dihydrocodeine can be synthesised from morphine by reduction of the 7,8-double bond. It readily converts to dihydromorphine with high yields (>95%).
 ==Pharmacology==
 Dihydrocodeine produces effects that are typical of μ-opioid agonists which suggests that it is pharmacologically similar to more traditional opioids such as codiene and morphine. These all appear to mimic endogenous endorphins. Endorphins are responsible for analgesia (reducing pain), causing sleepiness, and feelings of pleasure. They can be released in response to pain, strenuous exercise, orgasm, or excitement. This mimicking of natural endorphins results in the drug's [[euphoric]], [[analgesic]] (pain relief), and [[anxiolytic]] (anti-anxiety) effects.