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Harmala alkaloid: Difference between revisions
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'''Tetrahydroharmine''' does not inhibit monoamine oxidase A. Instead, it weakly inhibits [[serotonin]] [[Reuptake inhibitor|reuptake inhibition]]. At dosages of 200mg, it has been reported to cause dream-like euphoria, pleasurable tingling sensations and a general array of [[psychedelic]] effects. | '''Tetrahydroharmine''' does not inhibit monoamine oxidase A. Instead, it weakly inhibits [[serotonin]] [[Reuptake inhibitor|reuptake inhibition]]. At dosages of 200mg, it has been reported to cause dream-like euphoria, pleasurable tingling sensations and a general array of [[psychedelic]] effects. | ||
==Toxicity and | ==Toxicity and harm potential== | ||
===Drug Interactions=== | ===Drug Interactions=== | ||
While safer than general [[MAOIs]], RIMAs still have highly dangerous and sometimes fatal interactions with many common drugs. In particular, they can cause serotonin syndrome or hypertensive crisis when combined with almost any antidepressant or stimulant, common migraine medications, certain herbs, or even most cold medicines (including decongestants, antihistamines, and cough syrup, nicotine, caffeine, etc). Sedatives are likely easier tolerated, but potentiation should be expected. | While safer than general [[MAOIs]], RIMAs still have highly dangerous and sometimes fatal interactions with many common drugs. In particular, they can cause serotonin syndrome or hypertensive crisis when combined with almost any antidepressant or stimulant, common migraine medications, certain herbs, or even most cold medicines (including decongestants, antihistamines, and cough syrup, nicotine, caffeine, etc). Sedatives are likely easier tolerated, but potentiation should be expected. | ||