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Harmala alkaloid: Difference between revisions
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While safer than general [[MAOIs]], RIMAs still have highly dangerous and sometimes fatal interactions with many common drugs. In particular, they can cause serotonin syndrome or hypertensive crisis when combined with almost any antidepressant or stimulant, common migraine medications, certain herbs, or even most cold medicines (including decongestants, antihistamines, and cough syrup, nicotine, caffeine, etc). Sedatives are likely easier tolerated, but potentiation should be expected. | While safer than general [[MAOIs]], RIMAs still have highly dangerous and sometimes fatal interactions with many common drugs. In particular, they can cause serotonin syndrome or hypertensive crisis when combined with almost any antidepressant or stimulant, common migraine medications, certain herbs, or even most cold medicines (including decongestants, antihistamines, and cough syrup, nicotine, caffeine, etc). Sedatives are likely easier tolerated, but potentiation should be expected. | ||
===Lethal | ===Lethal dosage=== | ||
When intravenously injected into mice, the LD<sub>50</sub> of harmine is 38mg/kg. There is no data for the other harmala alkaloids in humans or animals. | When intravenously injected into mice, the LD<sub>50</sub> of harmine is 38mg/kg. There is no data for the other harmala alkaloids in humans or animals. | ||