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Routes of administration: Difference between revisions
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The method in which a substance has been ingested can greatly effect the potency, duration, and overall experience of a drug. Many substances are more effective when consumed using certain ROAs over others, and some drugs are completely inactive using certain routes of administration. Determining a route of administration is highly dependent on the substance consumed, desired duration of the substance,and personal comfort. | The method in which a substance has been ingested can greatly effect the potency, duration, and overall experience of a drug. Many substances are more effective when consumed using certain ROAs over others, and some drugs are completely inactive using certain routes of administration. Determining a route of administration is highly dependent on the substance consumed, desired duration of the substance, and personal comfort. | ||
===Oral=== | ===Oral=== | ||
Arguably the most common route of administration for most classes of drugs, oral administration allows a substance to be absorbed through blood vessels contained in the stomach. Onset is generally slower than other methods of ingestion, varying between substances.<ref>http://www.nature.com/clpt/journal/v28/n3/abs/clpt1980181a.html</ref> This method can also cause a greater propensity for nausea compared to other methods, and duration and absorption is longer.<ref>http://journals.lww.com/anesthesia-analgesia/Abstract/1988/12000/Analgesic_and_Hyperalgesic_Effects_of_Midazolam_.10.aspx</ref><ref>http://www.google.com/patents/US4229447</ref> | Arguably the most common route of administration for most classes of drugs, oral administration allows a substance to be absorbed through blood vessels contained in the stomach. Onset is generally slower than other methods of ingestion, varying between substances.<ref>http://www.nature.com/clpt/journal/v28/n3/abs/clpt1980181a.html</ref> This method can also cause a greater propensity for nausea compared to other methods, and duration and absorption is longer.<ref>http://journals.lww.com/anesthesia-analgesia/Abstract/1988/12000/Analgesic_and_Hyperalgesic_Effects_of_Midazolam_.10.aspx</ref><ref>http://www.google.com/patents/US4229447</ref> | ||