Glutamate: Difference between revisions

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Many nootropics and ampakine (a class of compounds known to enhance attention span and alertness) drugs are positive modulators of the AMPA glutamate receptor. These include piracetam, aniracetam and unifiram.

*'''Antagonists'''

A glutamate receptor [[antagonist]] is a type of receptor drug that inhibits action at glutamate receptors. [[Alcohol|Ethanol]] acts as an antagonist against the NMDA, AMPA and Kainate glutamate receptors, along with several antiepileptic drugs. Many [[dissociatives|dissociative]] drugs are antagonists against the NMDA glutamate receptor, including [[ketamine]], [[MXE]], [[PCP]] and [[DXM]]. [[Tramadol]] and [[ibogaine]] are dual antagonists against the NMDA glutamate receptor and opioid receptors.

A glutamate receptor [[antagonist]] is a type of receptor drug that inhibits action at glutamate receptors. [[Alcohol|Ethanol]] acts as an antagonist against the NMDA, AMPA and Kainate glutamate receptors, along with several antiepileptic drugs. Many [[dissociatives|dissociative]] drugs are antagonists against the NMDA glutamate receptor, including [[ketamine]], [[MXE]], [[PCP]] and [[DXM]]. [[Tramadol]] and [[ibogaine]] are dual antagonists against the NMDA glutamate receptor and opioid receptors. One atypical antagonist is [[Theanine]], which is not known to produce dissociative anesthesia at any dose, but has other psychoactive properties.

*'''Negative Allosteric Modulators'''

A negative allosteric modulator is a substance which indirectly influences the effects of an inverse agonist at a receptor, by binding to a site distinct from that of the inverse agonist binding site. Usually they induce a structural change within the receptor structure.

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 Many nootropics and ampakine (a class of compounds known to enhance attention span and alertness) drugs are positive modulators of the AMPA glutamate receptor. These include piracetam, aniracetam and unifiram.
 *'''Antagonists'''
-A glutamate receptor [[antagonist]] is a type of receptor drug that inhibits action at glutamate receptors. [[Alcohol|Ethanol]] acts as an antagonist against the NMDA, AMPA and Kainate glutamate receptors, along with several antiepileptic drugs. Many [[dissociatives|dissociative]] drugs are antagonists against the NMDA glutamate receptor, including [[ketamine]], [[MXE]], [[PCP]] and [[DXM]]. [[Tramadol]] and [[ibogaine]] are dual antagonists against the NMDA glutamate receptor and opioid receptors.
+A glutamate receptor [[antagonist]] is a type of receptor drug that inhibits action at glutamate receptors. [[Alcohol|Ethanol]] acts as an antagonist against the NMDA, AMPA and Kainate glutamate receptors, along with several antiepileptic drugs. Many [[dissociatives|dissociative]] drugs are antagonists against the NMDA glutamate receptor, including [[ketamine]], [[MXE]], [[PCP]] and [[DXM]]. [[Tramadol]] and [[ibogaine]] are dual antagonists against the NMDA glutamate receptor and opioid receptors. One atypical antagonist is [[Theanine]], which is not known to produce dissociative anesthesia at any dose, but has other psychoactive properties.
 *'''Negative Allosteric Modulators'''
 A negative allosteric modulator is a substance which indirectly influences the effects of an inverse agonist at a receptor, by binding to a site distinct from that of the inverse agonist binding site. Usually they induce a structural change within the receptor structure.