Harmala alkaloid: Difference between revisions

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Harmala alkaloids are selective for MOA-A at reasonable doses and binds to the enzyme temporarily so is classed as a ''[[RIMA|reversible inhibitor of Monoamine-A]]'' ('''[[RIMA]]'''). At higher doses, they also begin to affect the MOA-B enzyme. Because of the reversible selectivity for MAO-A, Harmala alkaloids are considered to be less dangerous in combination with food which contains [[tyramine]] and other substances with monoamine moieties, which are reliant on monoamine oxidase for decomposition, as is traditionally a respected consideration when using non-selective MAOIs in a clinical setting.

However, it is important to understand that this does not imply that Harmala alkaloids will not cause neurotoxicity. Harmala alkaloids temporarily disable the brain's primary mechanism for breaking down neurotransmitters and drugs, which can have negative consequences as material builds up in the synapses, leading to a huge range of downstream central and peripheral effects including; [[Physical effects: Sedation|sedation]], [[Physical effects: Stimulation|stimulation]], [[Cognitive effects: Anxiety|anxiety]], [[Physical effects: dysphoria|Dysphoria]], [[Physical ~~effects: Euphoria~~|euphoria]], [[Headaches|headaches]], [[Physical effects: Eye strain|eye strain]], [[Physical effects: Convulsions|convulsions]], etc.

However, it is important to understand that this does not imply that Harmala alkaloids will not cause neurotoxicity. Harmala alkaloids temporarily disable the brain's primary mechanism for breaking down neurotransmitters and drugs, which can have negative consequences as material builds up in the synapses, leading to a huge range of downstream central and peripheral effects including; [[Physical effects: Sedation|sedation]], [[Physical effects: Stimulation|stimulation]], [[Cognitive effects: Anxiety|anxiety]], [[Physical effects: dysphoria|Dysphoria]], [[Physical euphoria|euphoria]], [[Headaches|headaches]], [[Physical effects: Eye strain|eye strain]], [[Physical effects: Convulsions|convulsions]], etc.

Since [[DMT]] is broken down by monoamine oxidase-A, inhibition of this enzyme allows for the oral activation of DMT, and prolongs the experience for the duration of the harmala alkaloids' effects. In combination, harmala alkaloids and DMT is known as [[Ayahuasca]].

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 Harmala alkaloids are selective for MOA-A at reasonable doses and binds to the enzyme temporarily so is classed as a ''[[RIMA|reversible inhibitor of Monoamine-A]]'' ('''[[RIMA]]'''). At higher doses, they also begin to affect the MOA-B enzyme. Because of the reversible selectivity for MAO-A, Harmala alkaloids are considered to be less dangerous in combination with food which contains [[tyramine]] and other substances with monoamine moieties, which are reliant on monoamine oxidase for decomposition, as is traditionally a respected consideration when using non-selective MAOIs in a clinical setting.
-However, it is important to understand that this does not imply that Harmala alkaloids will not cause neurotoxicity. Harmala alkaloids temporarily disable the brain's primary mechanism for breaking down neurotransmitters and drugs, which can have negative consequences as material builds up in the synapses, leading to a huge range of downstream central and peripheral effects including; [[Physical effects: Sedation|sedation]], [[Physical effects: Stimulation|stimulation]], [[Cognitive effects: Anxiety|anxiety]], [[Physical effects: dysphoria|Dysphoria]], [[Physical effects: Euphoria|euphoria]], [[Headaches|headaches]], [[Physical effects: Eye strain|eye strain]], [[Physical effects: Convulsions|convulsions]], etc.
+However, it is important to understand that this does not imply that Harmala alkaloids will not cause neurotoxicity. Harmala alkaloids temporarily disable the brain's primary mechanism for breaking down neurotransmitters and drugs, which can have negative consequences as material builds up in the synapses, leading to a huge range of downstream central and peripheral effects including; [[Physical effects: Sedation|sedation]], [[Physical effects: Stimulation|stimulation]], [[Cognitive effects: Anxiety|anxiety]], [[Physical effects: dysphoria|Dysphoria]], [[Physical euphoria|euphoria]], [[Headaches|headaches]], [[Physical effects: Eye strain|eye strain]], [[Physical effects: Convulsions|convulsions]], etc.
 Since [[DMT]] is broken down by monoamine oxidase-A, inhibition of this enzyme allows for the oral activation of DMT, and prolongs the experience for the duration of the harmala alkaloids' effects. In combination, harmala alkaloids and DMT is known as [[Ayahuasca]].