Routes of administration: Difference between revisions

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The method in which a substance has been ingested can greatly effect the potency, duration, and overall experience of a drug. Many substances are more effective when consumed using certain ROA's over others, and some drugs are completely inactive using certain routes of administration. Determining a route of administration is highly dependent on the substance consumed, desired duration of the substance,and personal comfort.

===Oral===

Arguably the most common route of adminstration for most classes of drugs, oral adminstration allows a substance to be absorbed through blood vessels contained in the stomach, where Enterochromaffin cells contain approximately 90% of the bodys serotonin.<ref>http://books.google.com/books?id=HkOhFssK5UIC&pg=PT161#v=o</ref>

Arguably the most common route of adminstration for most classes of drugs, oral adminstration allows a substance to be absorbed through blood vessels contained in the stomach, where Enterochromaffin cells contain approximately 90% of the bodys serotonin.<ref>http://books.google.com/books?id=HkOhFssK5UIC&pg=PT161#v=o</ref> Onset is generally slower than other methods of ingestion, varying between substances. This method can also cause a greater propensity for nausea compared to other methods, and duration and absorption is longer.

===Sublingual===

Sublingual administration refers to absorption under the tounge. It is a common route of administration for drugs such as [[LSD]]. Sublingual administration can result in a faster absorption. It also circumvents the GI tracts tendency to break down certain drugs, such as [[25I-NBOMe]], which absorbs sublingual and buccal but not orally. Sublingual administration results in the substance being absorbed through the large lingual artery present underneath the tounge.

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 The method in which a substance has been ingested can greatly effect the potency, duration, and overall experience of a drug. Many substances are more effective when consumed using certain ROA's over others, and some drugs are completely inactive using certain routes of administration. Determining a route of administration is highly dependent on the substance consumed, desired duration of the substance,and personal comfort.
 ===Oral===
-Arguably the most common route of adminstration for most classes of drugs, oral adminstration allows a substance to be absorbed through blood vessels contained in the stomach, where Enterochromaffin cells contain approximately 90% of the bodys serotonin.<ref>http://books.google.com/books?id=HkOhFssK5UIC&pg=PT161#v=o</ref>
+Arguably the most common route of adminstration for most classes of drugs, oral adminstration allows a substance to be absorbed through blood vessels contained in the stomach, where Enterochromaffin cells contain approximately 90% of the bodys serotonin.<ref>http://books.google.com/books?id=HkOhFssK5UIC&pg=PT161#v=o</ref> Onset is generally slower than other methods of ingestion, varying between substances. This method can also cause a greater propensity for nausea compared to other methods, and duration and absorption is longer.
 ===Sublingual===
 Sublingual administration refers to absorption under the tounge. It is a common route of administration for drugs such as [[LSD]]. Sublingual administration can result in a faster absorption. It also circumvents the GI tracts tendency to break down certain drugs, such as [[25I-NBOMe]], which absorbs sublingual and buccal but not orally. Sublingual administration results in the substance being absorbed through the large lingual artery present underneath the tounge.