Routes of administration: Difference between revisions

Line 2:

The method in which a drug has been ingested can greatly effect the potency, duration, and overall experience of a drug. Many substances are more effective when consumed using certain ROA's over others, and some drugs are completely inactive using certain routes of administration. Determining a route of administration is highly dependent on the substance consumed, desired duration of the substance,and personal comfort.

===Oral===

Arguably the most common route of adminstration for most classes of drugs, oral adminstration allows a substance to be absorbed through blood vessels contained in the stomach, where Enterochromaffin cells contain approximately 90% of the bodys serotonin. ~~[1] Due to this, absorption of serotonin releasing drugs such as [[MDMA]], [[BK-MDMA]], and [[MDAI]] have been shown to have a higher overall effectivity when compared to insufflation~~.

Arguably the most common route of adminstration for most classes of drugs, oral adminstration allows a substance to be absorbed through blood vessels contained in the stomach, where Enterochromaffin cells contain approximately 90% of the bodys serotonin.<ref>http://books.google.com/books?id=HkOhFssK5UIC&pg=PT161#v=o</ref>

===Sublingual===

Sublingual administration refers to absorption under the tounge. It is a common route of administration for drugs such as [[LSD]]. Sublingual administration can result in a fast absorption bypassing the GI tracts tendency to break down certain drugs, such as [[25I-NBOMe]], which absorbs sublingual and buccal but not orally. Sublingual administration results in the substance being absorbed through the large Lingual artery present underneath the tounge.

@@ Line 2: / Line 2: @@
 The method in which a drug has been ingested can greatly effect the potency, duration, and overall experience of a drug. Many substances are more effective when consumed using certain ROA's over others, and some drugs are completely inactive using certain routes of administration. Determining a route of administration is highly dependent on the substance consumed, desired duration of the substance,and personal comfort.
 ===Oral===
-Arguably the most common route of adminstration for most classes of drugs, oral adminstration allows a substance to be absorbed through blood vessels contained in the stomach, where Enterochromaffin cells contain approximately 90% of the bodys serotonin. [1] Due to this, absorption of serotonin releasing drugs such as [[MDMA]], [[BK-MDMA]], and [[MDAI]] have been shown to have a higher overall effectivity when compared to insufflation.
+Arguably the most common route of adminstration for most classes of drugs, oral adminstration allows a substance to be absorbed through blood vessels contained in the stomach, where Enterochromaffin cells contain approximately 90% of the bodys serotonin.<ref>http://books.google.com/books?id=HkOhFssK5UIC&pg=PT161#v=o</ref>
 ===Sublingual===
 Sublingual administration refers to absorption under the tounge. It is a common route of administration for drugs such as [[LSD]]. Sublingual administration can result in a fast absorption bypassing the GI tracts tendency to break down certain drugs, such as [[25I-NBOMe]], which absorbs sublingual and buccal but not orally. Sublingual administration results in the substance being absorbed through the large Lingual artery present underneath the tounge.