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Cannabinoid: Difference between revisions
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CB1 receptors are found primarily in the brain, more specifically in the basal ganglia and in the limbic system, including the hippocampus.<ref>The endocannabinoid system as an emerging target of pharmacotherapy | http://www.ncbi.nlm.nih.gov/pubmed/16968947 </ref> They are also found in the cerebellum and in both male and female reproductive systems. CB1 receptors are absent in the medulla oblongata, the part of the brain stem responsible for respiratory and cardiovascular functions. Thus, there is not the risk of respiratory or cardiovascular failure that can be produced by some drugs. CB1 receptors appear to be responsible for the euphoric and anticonvulsive effects of cannabis. | CB1 receptors are found primarily in the brain, more specifically in the basal ganglia and in the limbic system, including the hippocampus.<ref>The endocannabinoid system as an emerging target of pharmacotherapy | http://www.ncbi.nlm.nih.gov/pubmed/16968947 </ref> They are also found in the cerebellum and in both male and female reproductive systems. CB1 receptors are absent in the medulla oblongata, the part of the brain stem responsible for respiratory and cardiovascular functions. Thus, there is not the risk of respiratory or cardiovascular failure that can be produced by some drugs. CB1 receptors appear to be responsible for the euphoric and anticonvulsive effects of cannabis. | ||
===Cannabinoid receptor type 2=== | ===Cannabinoid receptor type 2=== | ||
CB2 receptors are predominantly found in the immune system, or immune-derived cells<ref>Is lipid signaling through cannabinoid 2 receptors part of a protective system? | http://www.ncbi.nlm.nih.gov/pubmed/21295074</ref> with the greatest density in the spleen. While found only in the peripheral nervous system, a report does indicate that CB2 is expressed by a subpopulation of microglia in the human cerebellum.<ref>Cannabinoid CB2 receptors are expressed by perivascular microglial cells in the human brain: an immunohistochemical study | http://www.ncbi.nlm.nih.gov/pubmed/15266552< | CB2 receptors are predominantly found in the immune system, or immune-derived cells<ref>Is lipid signaling through cannabinoid 2 receptors part of a protective system? | http://www.ncbi.nlm.nih.gov/pubmed/21295074</ref> with the greatest density in the spleen. While found only in the peripheral nervous system, a report does indicate that CB2 is expressed by a subpopulation of microglia in the human cerebellum.<ref>Cannabinoid CB2 receptors are expressed by perivascular microglial cells in the human brain: an immunohistochemical study | http://www.ncbi.nlm.nih.gov/pubmed/15266552</ref> CB2 receptors appear to be responsible for the anti-inflammatory and possibly other therapeutic effects of cannabis.<ref>Is lipid signaling through cannabinoid 2 receptors part of a protective system? | http://www.ncbi.nlm.nih.gov/pubmed/21295074</ref> | ||
==Subjective effects== | ==Subjective effects== | ||