Acetylcholine: Difference between revisions

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===Drugs targeting the cholinergic system===

*'''Agonists'''

An acetylcholine receptor [[agonist]] works by increasing the level of receptor activation, either directly or indirectly. Direct agonists work by imitating the neurotransmitter; an example of this is the stimulant drug nicotine. Indirect agonists most often work by inhibiting the enzyme acetylcholinesterase; this enzyme breaks down acetylcholine, and therefore inhibition of it increases activation of cholinergic receptors. The stimulant drug caffeine is an indirect agonist, as is THC. These work by blocking Acetylcholine esterate, which is an enzyme that breaks down acetylcholine, leading to an increased build up over time.

An acetylcholine receptor [[agonist]] works by increasing the level of receptor activation, either directly or indirectly. Direct agonists work by imitating the neurotransmitter; an example of this is the stimulant drug nicotine. Indirect agonists most often work by inhibiting the enzyme acetylcholinesterase; this enzyme breaks down acetylcholine, and therefore inhibition of it increases activation of cholinergic receptors. The stimulant drug caffeine is an indirect agonist, as is [[THC]]. These work by blocking Acetylcholine esterate, which is an enzyme that breaks down acetylcholine, leading to an increased build up over time.

*'''Antagonists'''

An acetylcholine receptor [[antagonist]] works by attaching to acetylcholine receptors to prevent agonists binding. The deliriant drugs [[atropine]], [[scopolamine]] and [[DPH]] all act as antagonists upon muscarinic receptors, as does the deadly neurotoxin BZ.

An acetylcholine receptor [[antagonist]] works by attaching to acetylcholine receptors to prevent agonists binding. The [[deliriant]] drugs [[atropine]], [[scopolamine]] and [[DPH]] all act as antagonists upon muscarinic receptors, as does the deadly neurotoxin BZ.

==See also==

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 ===Drugs targeting the cholinergic system===
 *'''Agonists'''
-An acetylcholine receptor [[agonist]] works by increasing the level of receptor activation, either directly or indirectly. Direct agonists work by imitating the neurotransmitter; an example of this is the stimulant drug nicotine. Indirect agonists most often work by inhibiting the enzyme acetylcholinesterase; this enzyme breaks down acetylcholine, and therefore inhibition of it increases activation of cholinergic receptors. The stimulant drug caffeine is an indirect agonist, as is THC. These work by blocking Acetylcholine esterate, which is an enzyme that breaks down acetylcholine, leading to an increased build up over time.
+An acetylcholine receptor [[agonist]] works by increasing the level of receptor activation, either directly or indirectly. Direct agonists work by imitating the neurotransmitter; an example of this is the stimulant drug nicotine. Indirect agonists most often work by inhibiting the enzyme acetylcholinesterase; this enzyme breaks down acetylcholine, and therefore inhibition of it increases activation of cholinergic receptors. The stimulant drug caffeine is an indirect agonist, as is [[THC]]. These work by blocking Acetylcholine esterate, which is an enzyme that breaks down acetylcholine, leading to an increased build up over time.
 *'''Antagonists'''
-An acetylcholine receptor [[antagonist]] works by attaching to acetylcholine receptors to prevent agonists binding. The deliriant drugs [[atropine]], [[scopolamine]] and [[DPH]] all act as antagonists upon muscarinic receptors, as does the deadly neurotoxin BZ.
+An acetylcholine receptor [[antagonist]] works by attaching to acetylcholine receptors to prevent agonists binding. The [[deliriant]] drugs [[atropine]], [[scopolamine]] and [[DPH]] all act as antagonists upon muscarinic receptors, as does the deadly neurotoxin BZ.
 ==See also==