This is an unofficial archive of PsychonautWiki as of 2025-08-11T15:14:44Z. Content on this page may be outdated, incomplete, or inaccurate. Please refer to the original page for the most up-to-date information.
Talk:Methiodone: Difference between revisions
>Roshni →Chemistry: I added a whole new page for the drug methiodone. |
>Roshni m Added a picture of the chemical structure of methiodone and I added to the intro "also known as IC-26." |
||
| Line 7: | Line 7: | ||
| duration = Several hours (estimated) | | duration = Several hours (estimated) | ||
}} | }} | ||
[[File:IC-26 structure.svg|thumb|Methiodone]] | |||
'''Methiodone''' (also known as '''IC-26''')is a synthetic opioid analgesic and structural analogue of methadone. It is primarily encountered as the iodide salt derivative and acts as a mu-opioid receptor agonist, producing opioid-like effects such as analgesia, sedation, euphoria, and respiratory depression.<ref>https://pubchem.ncbi.nlm.nih.gov/compound/Methiodone</ref> | |||
==Chemistry== | |||
== Chemistry == | |||
Methiodone is chemically described as the iodide salt of a methadone analogue. Its chemical formula is C21H28INO.<ref>https://pubchem.ncbi.nlm.nih.gov/compound/Methiodone</ref> The iodide salt improves water solubility compared to the methadone base. The compound belongs to the diphenylheptanone class of opioids, characterized by a seven-carbon backbone with two phenyl rings and a ketone group. Its chemical name according to patents is (±)-6-(dimethylamino)-4,4-diphenylheptan-3-one iodide.<ref>https://patents.google.com/patent/US2722457A/en</ref> | Methiodone is chemically described as the iodide salt of a methadone analogue. Its chemical formula is C21H28INO.<ref>https://pubchem.ncbi.nlm.nih.gov/compound/Methiodone</ref> The iodide salt improves water solubility compared to the methadone base. The compound belongs to the diphenylheptanone class of opioids, characterized by a seven-carbon backbone with two phenyl rings and a ketone group. Its chemical name according to patents is (±)-6-(dimethylamino)-4,4-diphenylheptan-3-one iodide.<ref>https://patents.google.com/patent/US2722457A/en</ref> | ||
== Pharmacology == | ==Pharmacology== | ||
Methiodone is presumed to be a potent mu-opioid receptor agonist, similar to methadone.<ref>Goodman & Gilman’s The Pharmacological Basis of Therapeutics, 13th Edition</ref><ref>Trescot AM, et al. Opioid pharmacology. Pain Physician. 2008 Mar;11(2 Suppl):S133-53. https://pubmed.ncbi.nlm.nih.gov/18443633/</ref> The opioid receptor agonism produces typical opioid effects such as analgesia, sedation, euphoria, respiratory depression, and potential for dependence and addiction. No direct pharmacological or clinical studies on methiodone exist; all knowledge is inferred from its close chemical relation to methadone and other diphenylheptanone opioids. | Methiodone is presumed to be a potent mu-opioid receptor agonist, similar to methadone.<ref>Goodman & Gilman’s The Pharmacological Basis of Therapeutics, 13th Edition</ref><ref>Trescot AM, et al. Opioid pharmacology. Pain Physician. 2008 Mar;11(2 Suppl):S133-53. https://pubmed.ncbi.nlm.nih.gov/18443633/</ref> The opioid receptor agonism produces typical opioid effects such as analgesia, sedation, euphoria, respiratory depression, and potential for dependence and addiction. No direct pharmacological or clinical studies on methiodone exist; all knowledge is inferred from its close chemical relation to methadone and other diphenylheptanone opioids. | ||
== Effects == | ==Effects== | ||
Effects are predicted based on the opioid class and include: | Effects are predicted based on the opioid class and include: | ||
== Dosage == | *Analgesia (pain relief) | ||
*Sedation and relaxation | |||
*Euphoria | |||
*Respiratory depression (dangerous at high doses) | |||
*Nausea and vomiting | |||
*Constipation | |||
*High potential for tolerance, dependence, and addiction | |||
==Dosage== | |||
There is no medically approved or documented dosage information. Any dosing is speculative and should be approached with extreme caution due to overdose risk. | There is no medically approved or documented dosage information. Any dosing is speculative and should be approached with extreme caution due to overdose risk. | ||
== Duration == | ==Duration== | ||
Estimated duration is several hours, roughly comparable to methadone (typically 8–12 hours), but specific pharmacokinetic data is unavailable.<ref>Eap CB, et al. Clinical pharmacokinetics of methadone. Clin Pharmacokinet. 2002;41(14):1235-65. https://pubmed.ncbi.nlm.nih.gov/12485646/</ref> | Estimated duration is several hours, roughly comparable to methadone (typically 8–12 hours), but specific pharmacokinetic data is unavailable.<ref>Eap CB, et al. Clinical pharmacokinetics of methadone. Clin Pharmacokinet. 2002;41(14):1235-65. https://pubmed.ncbi.nlm.nih.gov/12485646/</ref> | ||
== History == | ==History== | ||
Methiodone was first synthesized in the 1950s as part of research into opioid analgesics aiming to improve methadone derivatives.<ref>https://patents.google.com/patent/US2722457A/en</ref><ref>Reynolds, James A. The Chemistry of Opium Alkaloids. 1957.</ref> It never gained medical approval or widespread use and remains mainly of chemical and patent interest. | Methiodone was first synthesized in the 1950s as part of research into opioid analgesics aiming to improve methadone derivatives.<ref>https://patents.google.com/patent/US2722457A/en</ref><ref>Reynolds, James A. The Chemistry of Opium Alkaloids. 1957.</ref> It never gained medical approval or widespread use and remains mainly of chemical and patent interest. | ||
== Legal status == | ==Legal status== | ||
Methiodone is not explicitly scheduled in most countries but, due to its opioid nature, it may fall under analogue or controlled substance laws depending on jurisdiction.<ref>EMCDDA – European Monitoring Centre for Drugs and Drug Addiction – NPS and analogue legislation reports</ref> Legal status should be checked locally. | Methiodone is not explicitly scheduled in most countries but, due to its opioid nature, it may fall under analogue or controlled substance laws depending on jurisdiction.<ref>EMCDDA – European Monitoring Centre for Drugs and Drug Addiction – NPS and analogue legislation reports</ref> Legal status should be checked locally. | ||
== Harm reduction and warnings == | ==Harm reduction and warnings== | ||
* Methiodone is a potent opioid with significant risk of respiratory depression and fatal overdose, especially without medical supervision. | |||
* Combining methiodone with other central nervous system depressants (alcohol, benzodiazepines, other opioids) greatly increases overdose risk. | *Methiodone is a potent opioid with significant risk of respiratory depression and fatal overdose, especially without medical supervision. | ||
* There is no reliable dosing information or clinical guidance for methiodone use. | *Combining methiodone with other central nervous system depressants (alcohol, benzodiazepines, other opioids) greatly increases overdose risk. | ||
* Dependence, addiction, and withdrawal symptoms are expected with repeated use. | *There is no reliable dosing information or clinical guidance for methiodone use. | ||
* Testing substances for purity and identity is recommended if obtained illicitly. | *Dependence, addiction, and withdrawal symptoms are expected with repeated use. | ||
* Seek emergency medical help immediately if signs of overdose occur (slow breathing, unconsciousness). | *Testing substances for purity and identity is recommended if obtained illicitly. | ||
* Use is strongly discouraged outside medical contexts. | *Seek emergency medical help immediately if signs of overdose occur (slow breathing, unconsciousness). | ||
*Use is strongly discouraged outside medical contexts. | |||
== References == | ==References== | ||
<references /> | <references /> | ||
== External links == | ==External links== | ||
* [PubChem entry for Methiodone](https://pubchem.ncbi.nlm.nih.gov/compound/Methiodone) | |||
* [US Patent US2722457A](https://patents.google.com/patent/US2722457A/en) | *[PubChem entry for Methiodone](https://pubchem.ncbi.nlm.nih.gov/compound/Methiodone) | ||
* [Goodman & Gilman’s The Pharmacological Basis of Therapeutics](https://accesspharmacy.mhmedical.com/book.aspx?bookid=2189) (textbook reference) | *[US Patent US2722457A](https://patents.google.com/patent/US2722457A/en) | ||
*[Goodman & Gilman’s The Pharmacological Basis of Therapeutics](https://accesspharmacy.mhmedical.com/book.aspx?bookid=2189) (textbook reference) | |||