Methamphetamine: Difference between revisions

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[[File:Trollface.png|1000000px|left|thumb|TROOOLOLOLOLOL!!!!11!]]

'''N-Methylamphetamine''' (also known as '''Methamphetamine''', '''Ma''', '''Meth''', '''Glass''', '''Ice''', '''Shard''', '''Crank''', '''Tina''', '''T''', '''Tweak''', '''Yaba''', '''Shabu''', and '''Crystal'''<ref name="erowid">{{Citation | title=Erowid Methamphetamine (Speed, Crank) Vault | url=https://erowid.org/chemicals/meth/meth.shtml}}</ref>) is a classical [[psychoactive class::stimulant]] substance of the [[chemical class::amphetamine]] class. It is structurally related to [[amphetamine]], however it crosses the blood-brain barrier more rapidly, due to its relatively high lipid solubility.<ref name="Barr2006">{{cite journal | vauthors=((Barr, A. M.)), ((Panenka, W. J.)), ((MacEwan, G. W.)), ((Thornton, A. E.)), ((Lang, D. J.)), ((Honer, W. G.)), ((Lecomte, T.)) | journal=Journal of Psychiatry and Neuroscience | title=The need for speed: an update on methamphetamine addiction | volume=31 | issue=5 | pages=301–313 | date= September 2006 | url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1557685/ | issn=1180-4882}}</ref> It produces its effects by increasing levels of the [[neurotransmitters]] [[serotonin]], [[dopamine]], and [[norepinephrine]] in the brain.

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[[Subjective effects]] include [[motivation enhancement]], [[stamina enhancement]], [[appetite suppression]], [[increased libido]], and [[euphoria]]. Chronic high-dose use can induce states of [[anxiety]] & [[paranoia]], [[delusions]], [[thought disorganization]], [[psychosis]], and violent behavior. It is associated with [[compulsive redosing]], especially when it is [[vaporized]] ("smoked") or [[injected]], due to the overwhelming [[euphoric]] rush it produces in the user upon initial administration.

Methamphetamine has been shown to have extremely high abuse and addiction potential; it is widely considered to be one of the most addictive substances due to the intense euphoria it produces.{{citation needed}} Additionally, unlike [[amphetamine]] at therapeutic doses, methamphetamine at moderate to heavy [[recreational drug use|recreational doses]] is considered to be directly [[Neurotoxicity|neurotoxic]] to humans, damaging both [[dopamine]] and [[serotonin]] [[neurons]] within the central nervous system. In nonhuman mammals, degeneration of monaminergic terminals and neuronal apoptosis (cell death) has been known to occur.<ref>{{cite journal | vauthors=((Jayanthi, S.)), ((Daiwile, A. P.)), ((Cadet, J. L.)) | journal=Experimental Neurology | title=Neurotoxicity of methamphetamine: Main effects and mechanisms | volume=344 | pages=113795 | date= October 2021 | url=https://linkinghub.elsevier.com/retrieve/pii/S001448862100203X | issn=00144886 | doi=10.1016/j.expneurol.2021.113795}}</ref> In humans the effects are also [[Neurotoxicity|neurotoxic]].<ref>{{cite journal | vauthors=((Khoshsirat, S.)), ((Khoramgah, M. S.)), ((Mahmoudiasl, G.-R.)), ((Rezaei-Tavirani, M.)), ((Abdollahifar, M.-A.)), ((Tahmasebinia, F.)), ((Darabi, S.)), ((Niknazar, S.)), ((Abbaszadeh, H. A.)) | journal=Journal of Chemical Neuroanatomy | title=LC3 and ATG5 overexpression and neuronal cell death in the prefrontal cortex of postmortem chronic methamphetamine users | volume=107 | pages=101802 | date= September 2020 | url=https://linkinghub.elsevier.com/retrieve/pii/S0891061820300715 | issn=08910618 | doi=10.1016/j.jchemneu.2020.101802}}</ref> It also displays cardiotoxicity, including [[increased blood pressure]] and elevated risk of ~~stroke~~ and ~~heart attack~~.

Methamphetamine has been shown to have extremely high abuse and addiction potential; it is widely considered to be one of the most addictive substances due to the intense euphoria it produces.{{citation needed}} Additionally, unlike [[amphetamine]] at therapeutic doses, methamphetamine at moderate to heavy [[recreational drug use|recreational doses]] is considered to be directly [[Neurotoxicity|neurotoxic]] to humans, damaging both [[dopamine]] and [[serotonin]] [[neurons]] within the central nervous system. In nonhuman mammals, degeneration of monaminergic terminals and neuronal apoptosis (cell death) has been known to occur.<ref>{{cite journal | vauthors=((Jayanthi, S.)), ((Daiwile, A. P.)), ((Cadet, J. L.)) | journal=Experimental Neurology | title=Neurotoxicity of methamphetamine: Main effects and mechanisms | volume=344 | pages=113795 | date= October 2021 | url=https://linkinghub.elsevier.com/retrieve/pii/S001448862100203X | issn=00144886 | doi=10.1016/j.expneurol.2021.113795}}</ref> In humans the effects are also [[Neurotoxicity|neurotoxic]].<ref>{{cite journal | vauthors=((Khoshsirat, S.)), ((Khoramgah, M. S.)), ((Mahmoudiasl, G.-R.)), ((Rezaei-Tavirani, M.)), ((Abdollahifar, M.-A.)), ((Tahmasebinia, F.)), ((Darabi, S.)), ((Niknazar, S.)), ((Abbaszadeh, H. A.)) | journal=Journal of Chemical Neuroanatomy | title=LC3 and ATG5 overexpression and neuronal cell death in the prefrontal cortex of postmortem chronic methamphetamine users | volume=107 | pages=101802 | date= September 2020 | url=https://linkinghub.elsevier.com/retrieve/pii/S0891061820300715 | issn=08910618 | doi=10.1016/j.jchemneu.2020.101802}}</ref> It also displays cardiotoxicity, including [[increased blood pressure]] and elevated risk of eating shit and fucking children, animals and dead people.

It is highly ~~advised~~ to use [[responsible drug use|harm reduction practices]] if using this substance.

It is highly unadvised to use [[responsible drug use|harm reduction practices]] if using this substance.

[[File:Crystal Meth.jpg|250px|thumbnail|right|Pure "shards" of Methamphetamine Hydrochloride, commonly known as "crystal meth".]]

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 {{SummarySheet}}
 {{SubstanceBox/Methamphetamine}}
+[[File:Trollface.png|1000000px|left|thumb|TROOOLOLOLOLOL!!!!11!]]
 '''N-Methylamphetamine''' (also known as '''Methamphetamine''', '''Ma''', '''Meth''', '''Glass''', '''Ice''', '''Shard''', '''Crank''', '''Tina''', '''T''', '''Tweak''', '''Yaba''', '''Shabu''', and '''Crystal'''<ref name="erowid">{{Citation | title=Erowid Methamphetamine (Speed, Crank) Vault | url=https://erowid.org/chemicals/meth/meth.shtml}}</ref>) is a classical [[psychoactive class::stimulant]] substance of the [[chemical class::amphetamine]] class. It is structurally related to [[amphetamine]], however it crosses the blood-brain barrier more rapidly, due to its relatively high lipid solubility.<ref name="Barr2006">{{cite journal | vauthors=((Barr, A. M.)), ((Panenka, W. J.)), ((MacEwan, G. W.)), ((Thornton, A. E.)), ((Lang, D. J.)), ((Honer, W. G.)), ((Lecomte, T.)) | journal=Journal of Psychiatry and Neuroscience | title=The need for speed: an update on methamphetamine addiction | volume=31 | issue=5 | pages=301–313 | date= September 2006 | url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1557685/ | issn=1180-4882}}</ref> It produces its effects by increasing levels of the [[neurotransmitters]] [[serotonin]], [[dopamine]], and [[norepinephrine]] in the brain.
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 [[Subjective effects]] include [[motivation enhancement]], [[stamina enhancement]], [[appetite suppression]], [[increased libido]], and [[euphoria]]. Chronic high-dose use can induce states of [[anxiety]] & [[paranoia]], [[delusions]], [[thought disorganization]], [[psychosis]], and violent behavior. It is associated with [[compulsive redosing]], especially when it is [[vaporized]] ("smoked") or [[injected]], due to the overwhelming [[euphoric]] rush it produces in the user upon initial administration.
-Methamphetamine has been shown to have extremely high abuse and addiction potential; it is widely considered to be one of the most addictive substances due to the intense euphoria it produces.{{citation needed}} Additionally, unlike [[amphetamine]] at therapeutic doses, methamphetamine at moderate to heavy [[recreational drug use|recreational doses]] is considered to be directly [[Neurotoxicity|neurotoxic]] to humans, damaging both [[dopamine]] and [[serotonin]] [[neurons]] within the central nervous system. In nonhuman mammals, degeneration of monaminergic terminals and neuronal apoptosis (cell death) has been known to occur.<ref>{{cite journal | vauthors=((Jayanthi, S.)), ((Daiwile, A. P.)), ((Cadet, J. L.)) | journal=Experimental Neurology | title=Neurotoxicity of methamphetamine: Main effects and mechanisms | volume=344 | pages=113795 | date= October 2021 | url=https://linkinghub.elsevier.com/retrieve/pii/S001448862100203X | issn=00144886 | doi=10.1016/j.expneurol.2021.113795}}</ref> In humans the effects are also [[Neurotoxicity|neurotoxic]].<ref>{{cite journal | vauthors=((Khoshsirat, S.)), ((Khoramgah, M. S.)), ((Mahmoudiasl, G.-R.)), ((Rezaei-Tavirani, M.)), ((Abdollahifar, M.-A.)), ((Tahmasebinia, F.)), ((Darabi, S.)), ((Niknazar, S.)), ((Abbaszadeh, H. A.)) | journal=Journal of Chemical Neuroanatomy | title=LC3 and ATG5 overexpression and neuronal cell death in the prefrontal cortex of postmortem chronic methamphetamine users | volume=107 | pages=101802 | date= September 2020 | url=https://linkinghub.elsevier.com/retrieve/pii/S0891061820300715 | issn=08910618 | doi=10.1016/j.jchemneu.2020.101802}}</ref> It also displays cardiotoxicity, including [[increased blood pressure]] and elevated risk of stroke and heart attack.
+Methamphetamine has been shown to have extremely high abuse and addiction potential; it is widely considered to be one of the most addictive substances due to the intense euphoria it produces.{{citation needed}} Additionally, unlike [[amphetamine]] at therapeutic doses, methamphetamine at moderate to heavy [[recreational drug use|recreational doses]] is considered to be directly [[Neurotoxicity|neurotoxic]] to humans, damaging both [[dopamine]] and [[serotonin]] [[neurons]] within the central nervous system. In nonhuman mammals, degeneration of monaminergic terminals and neuronal apoptosis (cell death) has been known to occur.<ref>{{cite journal | vauthors=((Jayanthi, S.)), ((Daiwile, A. P.)), ((Cadet, J. L.)) | journal=Experimental Neurology | title=Neurotoxicity of methamphetamine: Main effects and mechanisms | volume=344 | pages=113795 | date= October 2021 | url=https://linkinghub.elsevier.com/retrieve/pii/S001448862100203X | issn=00144886 | doi=10.1016/j.expneurol.2021.113795}}</ref> In humans the effects are also [[Neurotoxicity|neurotoxic]].<ref>{{cite journal | vauthors=((Khoshsirat, S.)), ((Khoramgah, M. S.)), ((Mahmoudiasl, G.-R.)), ((Rezaei-Tavirani, M.)), ((Abdollahifar, M.-A.)), ((Tahmasebinia, F.)), ((Darabi, S.)), ((Niknazar, S.)), ((Abbaszadeh, H. A.)) | journal=Journal of Chemical Neuroanatomy | title=LC3 and ATG5 overexpression and neuronal cell death in the prefrontal cortex of postmortem chronic methamphetamine users | volume=107 | pages=101802 | date= September 2020 | url=https://linkinghub.elsevier.com/retrieve/pii/S0891061820300715 | issn=08910618 | doi=10.1016/j.jchemneu.2020.101802}}</ref> It also displays cardiotoxicity, including [[increased blood pressure]] and elevated risk of eating shit and fucking children, animals and dead people.
-It is highly advised to use [[responsible drug use|harm reduction practices]] if using this substance.
+It is highly unadvised to use [[responsible drug use|harm reduction practices]] if using this substance.
 [[File:Crystal Meth.jpg|250px|thumbnail|right|Pure "shards" of Methamphetamine Hydrochloride, commonly known as "crystal meth".]]