Talk:Amitriptyline: Difference between revisions

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-Found an old box in my attic that wasnt expired and did some human testing on my self.
-They were 25mg pills.
+Amitriptyline
+Chemical Nomenclature
+Common names
+common name::Amitriptyline, Amitrip, Amitryptaline
+Systematic name
+(5α,6α)-7,8-Didehydro-4,5-epoxy-3-methoxy-17-methylmorphinan-6-ol
+Class Membership
+Psychoactive class
+Psychoactive class::Antidepressant
+Chemical class
+Chemical class::Tricyclic antidepressants
+Routes of Administration
-I can only make a dosage and effects list.
+WARNING: Always start with lower doses due to differences between individual body weight, tolerance, metabolism, and personal sensitivity. See responsible use section.
-Threshold 5 mg Light 5 - 15 mg Common 15 - 35 mg Strong 35 - 60 mg Heavy 60 mg +
+⇣ Oral
+Dosage
+Threshold
+Oral threshold dose::10
+Oral dose units::mg
+Light
+Oral min light dose::10
+-
+Oral max light dose::20
+mg
+Common
+Oral min common dose::20
+-
+Oral max common dose::50
+mg
+Strong
+Oral min strong dose::50
+-
+Oral max strong dose::100
+mg
+Heavy
+Oral heavy dose::150
+mg
+Duration
+Total
+Oral min total time::
+-
+Oral max total time::
+Oral total time units::hours
+Onset
+Oral min onset time::
+-
+Oral max onset time::
+Oral onset time units::minutes
+Come up
+Oral min comeup time::
+-
+Oral max comeup time::
+Oral comeup time units::hours
+Peak
+Oral min peak time::
+-
+Oral max peak time::
+Oral peak time units::hours
+Offset
+Oral min offset time::
+-
+Oral max offset time::
+Oral offset time units::hours
-Effects: Mostly hella sedation that leads to you falling asleep pretty quick. But if u resist its a light cognitive euphoria and a nice body euphoria.
+DISCLAIMER: PW's dosage information is gathered from users and resources for educational purposes only. It is not a recommendation and should be verified with other sources for accuracy.
+Interactions
+Amitriptyline (trade name Elavil or Vanatrip) is a tricyclic antidepressant drug used to treat depression, chronic neuropathic pain and migraines. It was first developed by the American pharmaceutical company Merck in the late 1950s. Amitriptyline is on the WHO Model List of Essential Medicines, the most important medications needed in a basic health system. Due to the frequency and prominence of side effects, amitriptyline is generally considered a second-line medication.
+History and culture
+In the 1950s the pharmaceutical company Merck proposed clinical trials to use amitriptyline as a treatment for schizophrenia, researcher Frank Ayd instead suggested that the medication be used as an antidepressant. Ayd treated 130 patients with amitriptyline and reported that it had similar qualities to imipramine, the first and only tricyclic antidepressant. It was approved for treatment of depression by the FDA in 1961.
+Pharmaceutical companies Roche and Lundbeck were also able to create patents on the drug thanks to a quirk of the patent law in the EU at the time allowing patents only on the chemical synthesis, but not on the drug itself.
+The drug quickly surpassed its predecessor, imipramine, because of its stronger anxiolytic effect and a campaign by the Merck company, raising awareness of depression as a clinical issue. Between 1998 and 2017 amitryptaline was the most prescribed antidepressant for 11-17 year olds in England
+Chemistry
+Pharmacology
+Subjective Effects
+Disclaimer: The effects listed below cite the Subjective Effect Index (SEI), an open research literature based on anecdotal user reports and the personal analyses of PsychonautWiki contributors. As a result, they should be viewed with a healthy degree of skepticism.
+It is also worth noting that these effects will not necessarily occur in a predictable or reliable manner, although higher doses are more liable to induce the full spectrum of effects. Likewise, adverse effects become increasingly likely with higher doses and may include addiction, severe injury, or death ☠.
+Toxicity and harm potential
+See also
+External links
+Amitriptyline (Wikipedia)
+Amitriptyline (DrugBank)