LSA: Difference between revisions

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LSA is chemically related to [[LSD]] and is said to produce similar effects, although the extent to which it does is unclear.

LSA was first described in 1932 as part of an investigation into the alkaloids found in ergot.<ref>{{cite journal|last1=Smith|first1=Sydney|last2=Timmis|first2=Geoffrey M.|title=The alkaloids of ergot. Part III. Ergine, a new base obtained by the degradation of ergotoxine and ergotinine|journal=Journal of the Chemical Society (Resumed)|year=1932|issue=98|edition=1932|pages=763-766|doi=10.1039/JR9320000763}}</ref> In 1947, it was synthesized and tested for human activity by [[Albert Hofmann]]. The [[intramuscular]] administration of a 500 microgram dose produced a "tired, dreamy state with an inability to maintain clear thoughts."<ref ~~name=~~"~~TiKHAL~~"~~>{{cite book|title=TiHKAL~~: ~~The Continuation|title~~-~~link=TiHKAL|last1=Shulgin|first1=Alexander|last2=Shulgin|first2=Ann|author~~-~~link1=Alexander Shulgin|year=1997|publisher=Transform Press|location=United States|isbn~~=0-~~9630096~~-9-~~9|oclc=38503252|chapter~~-~~url=https~~:/~~/erowid~~.~~org~~/~~library/books_online/tihkal/tihkal26~~.~~shtml|chapter=#26. LSD-25}}~~</ref>

LSA was first described in 1932 as part of an investigation into the alkaloids found in ergot.<ref>{{cite journal|last1=Smith|first1=Sydney|last2=Timmis|first2=Geoffrey M.|title=The alkaloids of ergot. Part III. Ergine, a new base obtained by the degradation of ergotoxine and ergotinine|journal=Journal of the Chemical Society (Resumed)|year=1932|issue=98|edition=1932|pages=763-766|doi=10.1039/JR9320000763}}</ref> In 1947, it was synthesized and tested for human activity by [[Albert Hofmann]]. The [[intramuscular]] administration of a 500 microgram dose produced a tired, dreamy state with an inability to maintain clear thoughts and high sensitivity to noises.<ref>Hofmann A (1963). [https://archive.org/details/biostor-160836 "The Active Principles of the Seeds of ''Rivea corymbosa'' and ''Ipomoea violacea''"]. ''Harvard Botanical Museum Leaflets''. '''20''' (6): 208–209

In 1970, LSA was detected as a constituent in Hawaiian baby woodrose seeds, which were being ground up into capsules and sold on the street as "mescaline".<ref>{{cite journal|last1=Miller|first1=Michael D.|title=Isolation and Identification of Lysergic Acid Amide and Isolysergic Acid Amide as the Principal Ergoline Alkaloids in ''Argyreia nervosa'', a Tropical Wood Rose|journal=Journal of the AOAC|year=1970|volume=53|issue=1|pages=123-128|issn=1060-3271|url=https://chemistry.mdma.ch/hiveboard/rhodium/pdf/forensic/lsa.hbwr.jaoac.pdf}}</ref> Today, LSA is typically consumed via [[LSA#Morning_glory_seeds_.28MGS.29|morning glory]] and [[LSA#Hawaiian_baby_woodrose_seeds_.28HBWR.29|Hawaiian baby woodrose]] seeds.<ref>{{cite journal|last1=Borsutzky|first1=M.|last2=Passie|first2=T.|last3=Paetzold|first3=W.|last4=Schneider|first4=U.|title=Hawaiian baby woodrose: (Psycho-) Pharmacological effects of the seeds of Argyreia nervosa. A case-orientated demonstration|journal=Der Nervenarzt|issn=0028-2804|doi=10.1007/s00115-002-1374-4|pmid=12215884|year=2002|volume=73|issue=9|pages=892-896}}</ref>

“D-lysergic acid amide (designation of compound undergoing tests: LA 111) was tested pharmacologically and clinically during the course of investigations on d-lysergic acid diethylamide (LSD 25) and related compounds long before it was known to be a component of ololiuhqui. Already at that stage we had, in experiments on ourselves, ascertained a psychotomimetic activity with a marked narcotic component with dosages of 0.5 to 1 mg. The following paragraph is taken from a hitherto unpublished record of the first experiment which the writer performed upon himself with LA 111 on 30.10.1947.”

10.00 h: Intramuscular injection of 0.5 ml of 1 per mille solution of LA 111 ( = 0.5 mg d-lysergic acid amide).

11.00 h: Tiredness in the neck, slight nausea.

11.05 h: Tired, dreamy, incapable of clear thoughts. Very sensitive to noises which give an unpleasant sensation.

11.10 h: Desire to lie down and sleep. Genuine physical and mental tiredness, which is not experienced as an unpleasant sensation. Slept for 3 hours.

15.00 h: Return of normal condition with full capacity for performing work.

“This action of d-lysergic acid amide was later confirmed by the comparative systematic investigation of H. Solms.<sup>26 27</sup> He describes the action as follows: LA 111 induces indifference, a decrease in psychomotor activity, the feeling of sinking into nothingness and a desire to sleep . . . until finally an increased clouding of consciousness does produce sleep.”

This plant is now considered to be ''Ipomoea tricolor''.

“Such a confusing example resulting in numerous false repetitions in studies of other authors has happened already in the first ergoline paper on ''Ipomoea tricolor'' Cav. whose seeds are known as “badoh negro”: Together with this correct synonym the species was incorrectly called ''I. violacea'' L. (Hofmann 1964) instead of ''I. violacea'' '''auct., non L.''' This is of importance since ''I. violacea'' L. is the currently accepted name of a different ''Ipomoea'' species, ''I. tuba'' (Schlecht.) G.Don (Austin and Huáman 1996).”

Eich E (January 12, 2008). "4.2.3 Occurrence in the Convolvulaceae (p. 224)". ''Solanaceae and Convolvulaceae - Secondary Metabolites: biosynthesis, chemotaxonomy, biological and economic significance: a handbook''. Berlin, Heidelberg: Springer-Verlag. doi:10.1007/978-3-540-74541-9. <nowiki>ISBN 978-3-540-74540-2</nowiki>. OCLC 195613136</ref> In 1970, LSA was detected as a constituent in Hawaiian baby woodrose seeds, which were being ground up into capsules and sold on the street as "mescaline".<ref>{{cite journal|last1=Miller|first1=Michael D.|title=Isolation and Identification of Lysergic Acid Amide and Isolysergic Acid Amide as the Principal Ergoline Alkaloids in ''Argyreia nervosa'', a Tropical Wood Rose|journal=Journal of the AOAC|year=1970|volume=53|issue=1|pages=123-128|issn=1060-3271|url=https://chemistry.mdma.ch/hiveboard/rhodium/pdf/forensic/lsa.hbwr.jaoac.pdf}}</ref> Today, LSA is typically consumed via [[LSA#Morning_glory_seeds_.28MGS.29|morning glory]] and [[LSA#Hawaiian_baby_woodrose_seeds_.28HBWR.29|Hawaiian baby woodrose]] seeds.<ref>{{cite journal|last1=Borsutzky|first1=M.|last2=Passie|first2=T.|last3=Paetzold|first3=W.|last4=Schneider|first4=U.|title=Hawaiian baby woodrose: (Psycho-) Pharmacological effects of the seeds of Argyreia nervosa. A case-orientated demonstration|journal=Der Nervenarzt|issn=0028-2804|doi=10.1007/s00115-002-1374-4|pmid=12215884|year=2002|volume=73|issue=9|pages=892-896}}</ref>

User reports describe the effects of LSA as primarily sedating and dream-like, with a mild to moderate psychedelic component. The psychedelic effects of LSA occur inconsistently and are not directly comparable to the effects of classical psychedelics like [[LSD]], [[psilocybin mushrooms]], or [[mescaline]]. LSA is described as primarily bodily and cognitive with little visual effects. Many users report serious [[nausea]] and bodily discomfort ("body load") when taking LSA-containing seeds.

@@ Line 6: / Line 6: @@
 LSA is chemically related to [[LSD]] and is said to produce similar effects, although the extent to which it does is unclear.
-LSA was first described in 1932 as part of an investigation into the alkaloids found in ergot.<ref>{{cite journal|last1=Smith|first1=Sydney|last2=Timmis|first2=Geoffrey M.|title=The alkaloids of ergot. Part III. Ergine, a new base obtained by the degradation of ergotoxine and ergotinine|journal=Journal of the Chemical Society (Resumed)|year=1932|issue=98|edition=1932|pages=763-766|doi=10.1039/JR9320000763}}</ref> In 1947, it was synthesized and tested for human activity by [[Albert Hofmann]]. The [[intramuscular]] administration of a 500 microgram dose produced a "tired, dreamy state with an inability to maintain clear thoughts."<ref name="TiKHAL">{{cite book|title=TiHKAL: The Continuation|title-link=TiHKAL|last1=Shulgin|first1=Alexander|last2=Shulgin|first2=Ann|author-link1=Alexander Shulgin|year=1997|publisher=Transform Press|location=United States|isbn=0-9630096-9-9|oclc=38503252|chapter-url=https://erowid.org/library/books_online/tihkal/tihkal26.shtml|chapter=#26. LSD-25}}</ref>
+LSA was first described in 1932 as part of an investigation into the alkaloids found in ergot.<ref>{{cite journal|last1=Smith|first1=Sydney|last2=Timmis|first2=Geoffrey M.|title=The alkaloids of ergot. Part III. Ergine, a new base obtained by the degradation of ergotoxine and ergotinine|journal=Journal of the Chemical Society (Resumed)|year=1932|issue=98|edition=1932|pages=763-766|doi=10.1039/JR9320000763}}</ref> In 1947, it was synthesized and tested for human activity by [[Albert Hofmann]]. The [[intramuscular]] administration of a 500 microgram dose produced a tired, dreamy state with an inability to maintain clear thoughts and high sensitivity to noises.<ref>Hofmann A (1963). [https://archive.org/details/biostor-160836 "The Active Principles of the Seeds of ''Rivea corymbosa'' and ''Ipomoea violacea''"]. ''Harvard Botanical Museum Leaflets''. '''20''' (6): 208–209
-In 1970, LSA was detected as a constituent in Hawaiian baby woodrose seeds, which were being ground up into capsules and sold on the street as "mescaline".<ref>{{cite journal|last1=Miller|first1=Michael D.|title=Isolation and Identification of Lysergic Acid Amide and Isolysergic Acid Amide as the Principal Ergoline Alkaloids in ''Argyreia nervosa'', a Tropical Wood Rose|journal=Journal of the AOAC|year=1970|volume=53|issue=1|pages=123-128|issn=1060-3271|url=https://chemistry.mdma.ch/hiveboard/rhodium/pdf/forensic/lsa.hbwr.jaoac.pdf}}</ref> Today, LSA is typically consumed via [[LSA#Morning_glory_seeds_.28MGS.29|morning glory]] and [[LSA#Hawaiian_baby_woodrose_seeds_.28HBWR.29|Hawaiian baby woodrose]] seeds.<ref>{{cite journal|last1=Borsutzky|first1=M.|last2=Passie|first2=T.|last3=Paetzold|first3=W.|last4=Schneider|first4=U.|title=Hawaiian baby woodrose: (Psycho-) Pharmacological effects of the seeds of Argyreia nervosa. A case-orientated demonstration|journal=Der Nervenarzt|issn=0028-2804|doi=10.1007/s00115-002-1374-4|pmid=12215884|year=2002|volume=73|issue=9|pages=892-896}}</ref>
+“D-lysergic acid amide (designation of compound undergoing tests: LA 111) was tested pharmacologically and clinically during the course of investigations on d-lysergic acid diethylamide (LSD 25) and related compounds long before it was known to be a component of ololiuhqui. Already at that stage we had, in experiments on ourselves, ascertained a psychotomimetic activity with a marked narcotic component with dosages of 0.5 to 1 mg. The following paragraph is taken from a hitherto unpublished record of the first experiment which the writer performed upon himself with LA 111 on 30.10.1947.”
+.00 h: Intramuscular injection of 0.5 ml of 1 per mille solution of LA 111 ( = 0.5 mg d-lysergic acid amide).
+.00 h: Tiredness in the neck, slight nausea.
+.05 h: Tired, dreamy, incapable of clear thoughts. Very sensitive to noises which give an unpleasant sensation.
+.10 h: Desire to lie down and sleep. Genuine physical and mental tiredness, which is not experienced as an unpleasant sensation. Slept for 3 hours.
+.00 h: Return of normal condition with full capacity for performing work.
+“This action of d-lysergic acid amide was later confirmed by the comparative systematic investigation of H. Solms.<sup>26 27</sup> He describes the action as follows: LA 111 induces indifference, a decrease in psychomotor activity, the feeling of sinking into nothingness and a desire to sleep . . . until finally an increased clouding of consciousness does produce sleep.”
+This plant is now considered to be ''Ipomoea tricolor''.
+“Such a confusing example resulting in numerous false repetitions in studies of other authors has happened already in the first ergoline paper on ''Ipomoea tricolor'' Cav. whose seeds are known as “badoh negro”: Together with this correct synonym the species was incorrectly called ''I. violacea'' L. (Hofmann 1964) instead of ''I. violacea'' '''auct., non L.''' This is of importance since ''I. violacea'' L. is the currently accepted name of a different ''Ipomoea'' species, ''I. tuba'' (Schlecht.) G.Don (Austin and Huáman 1996).”
+Eich E (January 12, 2008). "4.2.3 Occurrence in the Convolvulaceae (p. 224)". ''Solanaceae and Convolvulaceae - Secondary Metabolites: biosynthesis, chemotaxonomy, biological and economic significance: a handbook''. Berlin, Heidelberg: Springer-Verlag. doi:10.1007/978-3-540-74541-9. <nowiki>ISBN 978-3-540-74540-2</nowiki>. OCLC 195613136</ref> In 1970, LSA was detected as a constituent in Hawaiian baby woodrose seeds, which were being ground up into capsules and sold on the street as "mescaline".<ref>{{cite journal|last1=Miller|first1=Michael D.|title=Isolation and Identification of Lysergic Acid Amide and Isolysergic Acid Amide as the Principal Ergoline Alkaloids in ''Argyreia nervosa'', a Tropical Wood Rose|journal=Journal of the AOAC|year=1970|volume=53|issue=1|pages=123-128|issn=1060-3271|url=https://chemistry.mdma.ch/hiveboard/rhodium/pdf/forensic/lsa.hbwr.jaoac.pdf}}</ref> Today, LSA is typically consumed via [[LSA#Morning_glory_seeds_.28MGS.29|morning glory]] and [[LSA#Hawaiian_baby_woodrose_seeds_.28HBWR.29|Hawaiian baby woodrose]] seeds.<ref>{{cite journal|last1=Borsutzky|first1=M.|last2=Passie|first2=T.|last3=Paetzold|first3=W.|last4=Schneider|first4=U.|title=Hawaiian baby woodrose: (Psycho-) Pharmacological effects of the seeds of Argyreia nervosa. A case-orientated demonstration|journal=Der Nervenarzt|issn=0028-2804|doi=10.1007/s00115-002-1374-4|pmid=12215884|year=2002|volume=73|issue=9|pages=892-896}}</ref>
 User reports describe the effects of LSA as primarily sedating and dream-like, with a mild to moderate psychedelic component. The psychedelic effects of LSA occur inconsistently and are not directly comparable to the effects of classical psychedelics like [[LSD]], [[psilocybin mushrooms]], or [[mescaline]]. LSA is described as primarily bodily and cognitive with little visual effects. Many users report serious [[nausea]] and bodily discomfort ("body load") when taking LSA-containing seeds.